Search Results - "JAFFE, Robert B"

Development and Function of the Human Fetal Adrenal Cortex: A Key Component in the Feto-Placental Unit by Ishimoto, Hitoshi, Jaffe, Robert B

“…The human fetal adrenal cortex, a pivotal member of the feto-placental unit, is a relatively large organ with steroidogenic activity that is spatially,…”
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Yen and Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management by Strauss, Jerome F, Barbieri, Robert L, Dokras, Anuja, Williams, Carmen J, Williams, S. Zev

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Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma by CHUNHUA LU, BONOME, Tomas, SOOD, Anil K, YANG LI, KAMAT, Aparna A, HAN, Liz Y, SCHMANDT, Rosemarie, COLEMAN, Robert L, GERSHENSON, David M, JAFFE, Robert B, BIRRER, Michael J

“…Therapeutic strategies based on antiangiogenic approaches are beginning to show great promise in clinical studies. However, full realization of these…”
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Biological Roles of the Delta Family Notch Ligand Dll4 in Tumor and Endothelial Cells in Ovarian Cancer by WEI HU, CHUNHUA LU, SUN JOO LEE, ROH, Ju-Won, MATSUO, Koji, NISHIMURA, Masato, GOODMAN, Blake W, JAFFE, Robert B, LANGLEY, Robert R, DEAVERS, Michael T, LOPEZ-BERESTEIN, Gabriel, COLEMAN, Robert L, HEE DONG HAN, SOOD, Anil K, JIE HUANG, SHEN, De-Yu, STONE, Rebecca L, NICK, Alpa M, SHAHZAD, Mian M. K, MORA, Edna, JENNINGS, Nicholas B

“…Emerging evidence suggests that the Notch/Delta-like ligand 4 (Dll4) pathway may offer important new targets for antiangiogenesis approaches. In this study, we…”
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Vascular Endothelial Growth Factor-Trap Decreases Tumor Burden, Inhibits Ascites, and Causes Dramatic Vascular Remodeling in an Ovarian Cancer Model by BYRNE, Annette T, ROSS, Leorah, HOLASH, Joceyln, NAKANISHI, Mikiye, LIMIN HU, HOFMANN, Judith I, YANCOPOULOS, George D, JAFFE, Robert B

“…Ovarian cancer is the most lethal gynecological malignancy and the fifth most common cause of cancer in women. It is characterized by diffuse peritoneal…”
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Role of vascular endothelial growth factor in ovarian physiology and pathology by Geva, E, Jaffe, R B

“…To review the current literature on the role of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in ovarian physiology and pathology…”
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Vascular Endothelial Growth Factor Trap Combined with Paclitaxel Strikingly Inhibits Tumor and Ascites, Prolonging Survival in a Human Ovarian Cancer Model by LIMIN HU, HOFMANN, Judith, HOLASH, Jocelyn, YANCOPOULOS, George D, SOOD, Anil K, JAFFE, Robert B

“…Ovarian cancer is characterized by i.p. carcinomatosis and massive ascites. Vascular endothelial growth factor (VEGF) plays a pivotal role in tumor…”
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Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer by KAMAT, Aparna A, TAE JIN KIM, HEYMACH, John V, JAFFE, Robert B, COLEMAN, Robert L, SOOD, Anil K, LANDEN, Charles N, CHUNHUA LU, HAN, Liz Y, LIN, Yvonne G, MERRITT, William M, THAKER, Premal H, GERSHENSON, David M, BISCHOFF, Farideh Z

“…Metronomic chemotherapy is the frequent administration of low doses of chemotherapeutic agents targeting tumor-associated endothelial cells. We examined the…”
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Human Placental Vascular Development: Vasculogenic and Angiogenic (Branching and Nonbranching) Transformation Is Regulated by Vascular Endothelial Growth Factor-A, Angiopoietin-1, and Angiopoietin-2 by Geva, Eli, Ginzinger, David G., Zaloudek, Charles J., Moore, Dan H., Byrne, Annette, Jaffe, Robert B.

“…During placental development, vessel formation occurs initially by vasculogenesis and subsequently by branching and nonbranching angiogenesis. We investigated…”
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Phosphatidylinostol 3-Kinase Mediates Angiogenesis and Vascular Permeability Associated with Ovarian Carcinoma by LIMIN HU, HOFMANN, Judith, JAFFE, Robert B

“…Purpose: To assess the role of phosphatidylinositol-3 kinase (PI3K) inhibition in vascular permeability, angiogenesis, and vascular remodeling in tumor vessels…”
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Vascular Endothelial Growth Factor Immunoneutralization Plus Paclitaxel Markedly Reduces Tumor Burden and Ascites in Athymic Mouse Model of Ovarian Cancer by Hu, Limin, Hofmann, Judith, Zaloudek, Charles, Ferrara, Napoleone, Hamilton, Thomas, Jaffe, Robert B.

“…Ovarian cancer is characterized by rapid growth of solid intraperitoneal tumors and production of large volumes of ascites. Our previous studies of…”
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Dual Targeting of Endothelial Cells and Pericytes in Antivascular Therapy for Ovarian Carcinoma by CHUNHUA LU, KAMAT, Aparna A, LOGSDON, Craig, JAFFE, Robert B, COLEMAN, Robert L, SOOD, Anil K, LIN, Yvonne G, MERRITT, William M, LANDEN, Charles N, KIM, Taejin, SPANNUTH, Whitney, ARUMUGAM, Thiru, HAN, Liz Y, JENNINGS, Nicholas B

“…Purpose: Pericytes are known to provide a survival advantage for endothelial cells. We hypothesize that strategies aimed at dual targeting of tumor-associated…”
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Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models by Lu, Chunhua, Shahzad, Mian M.K., Moreno-Smith, Myrthala, Lin, Yvonne, Jennings, Nicholas B., Allen, Julie K., Landen, Charles N., Mangala, Lingegowda S., Armaiz-Pena, Guillermo N., Schmandt, Rosemarie, Nick, Alpa M., Stone, Rebecca L., Jaffe, Robert B., Coleman, Robert L., Sood, Anil K.

“…Purpose: On the basis of the known role of platelet-derived growth factor (PDGF)-BB/PDGF receptor (PDGFR) β in pericyte regulation, highly specific inhibitors…”
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Impact of vessel maturation on antiangiogenic therapy in ovarian cancer by Lu, Chunhua, MD, PhD, Thaker, Premal H., MD, Lin, Yvonne G., MD, Spannuth, Whitney, MD, Landen, Charles N., MD, Merritt, William M., MD, Jennings, Nicholas B., BS, Langley, Robert R., PhD, Gershenson, David M., MD, Yancopoulos, George D., MD, PhD, Ellis, Lee M., MD, Jaffe, Robert B., MD, Coleman, Robert L., MD, Sood, Anil K., MD

“…Objective The purpose of this study was to examine the functional and therapeutic significance of pericytes in ovarian cancer vasculature. Study Design Tumor…”
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Tissue Distribution of Estrogen Receptors Alpha (ER-α) and Beta (ER-β) mRNA in the Midgestational Human Fetus by Brandenberger, Alfred W, Tee, Meng Kian, Lee, Janet Y, Chao, Victor, Jaffe, Robert B

“…We compared the expression profiles of the mRNAs of both estrogen receptors, ER-α and the recently cloned ER-β, in the midgestational human fetus by…”
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The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study by Mersereau, Jennifer E., M.D, Khouri, Claire, B.A, Jaffe, Robert B., M.D

“…Compared with placebo, alendronate treatment resulted in a significant protection against bone loss in healthy perimenopausal women. This protection occurred…”
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A challenge for the 21st century: whither physician-scientists in obstetrics, gynecology, and the reproductive sciences? by Longo, Lawrence D., MD, Jaffe, Robert B., MD

“…As we begin a new century, research in obstetrics and gynecology and its subspecialties face a crisis. Federal support to academic departments of obstetrics…”
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Anti-angiogenic properties of metronomic topotecan in ovarian carcinoma by Merritt, William M., Danes, Christopher G., Shahzad, Mian M.K., Lin, Yvonne G., Kamat, Aparna A., Han, Liz Y., Spannuth, Whitney A., Nick, Alpa M., Mangala, Lingegowda S., Stone, Rebecca L., Kim, Hye Sun, Gershenson, David M., Jaffe, Robert B., Coleman, Robert L., Chandra, Joya, Sood, Anil K.

“…Purpose: Metronomic chemotherapy regimens have shown anti-tumor activity by anti-angiogenic mechanisms, however, the efficacy of metronomic topotecan in…”
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Regulation of Tumor Angiogenesis by EZH2 by Lu, Chunhua, Han, Hee Dong, Mangala, Lingegowda S., Ali-Fehmi, Rouba, Newton, Christopher S., Ozbun, Laurent, Armaiz-Pena, Guillermo N., Hu, Wei, Stone, Rebecca L., Munkarah, Adnan, Ravoori, Murali K., Shahzad, Mian M.K., Lee, Jeong-Won, Mora, Edna, Langley, Robert R., Carroll, Amy R., Matsuo, Koji, Spannuth, Whitney A., Schmandt, Rosemarie, Jennings, Nicholas B., Goodman, Blake W., Jaffe, Robert B., Nick, Alpa M., Kim, Hye Sun, Guven, Eylem Ozturk, Chen, Ya-Huey, Li, Long-Yuan, Hsu, Ming-Chuan, Coleman, Robert L., Calin, George A., Denkbas, Emir B., Lim, Jae Yun, Lee, Ju-Seog, Kundra, Vikas, Birrer, Michael J., Hung, Mien-Chie, Lopez-Berestein, Gabriel, Sood, Anil K.

“…Although VEGF-targeted therapies are showing promise, new angiogenesis targets are needed to make additional gains. Here, we show that increased Zeste homolog…”
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In Memoriam: Pentti K. Siiteri, Ph.D. Editor-in-Chief, Endocrine Reviews, 1985–1990 by Jaffe, Robert B

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