Search Results - "JAESCHKE, HARTMUT"

Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts by Jaeschke, Hartmut

“…Liver cell death induced by stresses such as ischemia‐reperfusion, cholestasis and drug toxicity can trigger a sterile inflammatory response with activation of…”
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Acetaminophen: Dose-Dependent Drug Hepatotoxicity and Acute Liver Failure in Patients by Jaeschke, Hartmut

“…Drug-induced liver injury is a rare but serious clinical problem. A number of drugs can cause severe liver injury and acute liver failure at therapeutic doses…”
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Mechanisms of Liver Injury. II. Mechanisms of neutrophil-induced liver cell injury during hepatic ischemia-reperfusion and other acute inflammatory conditions by Jaeschke, Hartmut

“…Polymorphonuclear leukocytes (neutrophils) are a vital part of the innate immune response to microbial infections and tissue trauma, e.g., ischemia-reperfusion…”
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Acetaminophen Hepatotoxicity by Ramachandran, Anup, Jaeschke, Hartmut

“…Acetaminophen (APAP) is one of the most popular and safe pain medications worldwide. However, due to its wide availability, it is frequently implicated in…”
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Mechanisms and pathophysiological significance of sterile inflammation during acetaminophen hepatotoxicity by Jaeschke, Hartmut, Ramachandran, Anup

“…Acetaminophen (APAP) is a widely used analgesic drug, which can cause severe liver injury after an overdose. The intracellular signaling mechanisms of…”
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Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure by Woolbright, Benjamin L, Jaeschke, Hartmut

“…Summary Drug-induced acute liver failure carries a high morbidity and mortality rate. Acetaminophen overdose is the number one cause of acute liver failure and…”
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Metabolism and Disposition of Acetaminophen: Recent Advances in Relation to Hepatotoxicity and Diagnosis by McGill, Mitchell R., Jaeschke, Hartmut

“…ABSTRACT Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and…”
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Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential by Du, Kuo, Ramachandran, Anup, Jaeschke, Hartmut

“…Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress. However, its source, pathophysiological role and possible therapeutic…”
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Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue—Recent Advances in Acetaminophen Hepatotoxicity by Jaeschke, Hartmut

“…Acetaminophen (N-acetyl-para-aminophenol (APAP)) is one of the most-studied drugs worldwide [...]…”
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Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity by Du, Kuo, Farhood, Anwar, Jaeschke, Hartmut

“…Acetaminophen (APAP) hepatotoxicity is characterized by an extensive mitochondrial oxidant stress. However, its importance as a drug target has not been…”
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Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning by Jaeschke, Hartmut

“…Ischemia-reperfusion injury is, at least in part, responsible for the morbidity associated with liver surgery under total vascular exclusion or after liver…”
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Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons learned from acetaminophen hepatotoxicity by Jaeschke, Hartmut, McGill, Mitchell R., Ramachandran, Anup

“…Hepatotoxicity is a serious problem during drug development and for the use of many established drugs. For example, acetaminophen overdose is currently the…”
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Novel insight into mechanisms of cholestatic liver injury by Woolbright, Benjamin L, Jaeschke, Hartmut

“…Cholestasis results in a buildup of bile acids in serum and in hepatocytes. Early studies into the mechanisms of cholestatic liver injury strongly implicated…”
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Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N‐acetylcysteine by Saito, Chieko, Zwingmann, Claudia, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is a major cause of acute liver failure. The glutathione (GSH) precursor N‐acetylcysteine (NAC) is used to treat patients with…”
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Emerging and established modes of cell death during acetaminophen-induced liver injury by Jaeschke, Hartmut, Ramachandran, Anup, Chao, Xiaojuan, Ding, Wen-Xing

“…Acetaminophen (APAP)-induced liver injury is an important clinical and toxicological problem. Understanding the mechanisms and modes of cell death are vital…”
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Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose by Akakpo, Jephte Y., Ramachandran, Anup, Curry, Steven C., Rumack, Barry H., Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N -acetylcysteine (NAC) is still the only FDA-approved antidote against APAP…”
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Current strategies to minimize hepatic ischemia–reperfusion injury by targeting reactive oxygen species by Jaeschke, Hartmut, Woolbright, Benjamin L

“…Abstract Ischemia–reperfusion is a major component of injury in vascular occlusion both during liver surgery and during liver transplantation. The…”
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The role of apoptosis in acetaminophen hepatotoxicity by Jaeschke, Hartmut, Duan, Luqi, Akakpo, Jephte Y., Farhood, Anwar, Ramachandran, Anup

“…Although necrosis is recognized as the main mode of cell death induced by acetaminophen (APAP) overdose in animals and humans, more recently an increasing…”
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Acetaminophen-induced liver injury in rats and mice: Comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity by McGill, Mitchell R., Williams, C. David, Xie, Yuchao, Ramachandran, Anup, Jaeschke, Hartmut

“…Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the West. In mice, APAP hepatotoxicity can be rapidly induced with a single…”
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Role and mechanisms of autophagy in acetaminophen‐induced liver injury by Chao, Xiaojuan, Wang, Hua, Jaeschke, Hartmut, Ding, Wen‐Xing

“…Acetaminophen (APAP) overdose is the most frequent cause of acute liver failure in the USA and many other countries. Although the metabolism and pathogenesis…”
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