Search Results - "JACOBS, E. G"

Pharmacological characterization of the selective orexin-1 receptor antagonist JNJ-61393215 in healthy volunteers by Brooks, S, Zuiker, RGJA, Bleys, C, Ziagkos, D, Moyer, JA, van Nueten, L, Bonaventure, P, Drevets, WC, van Gerven, JMA, Salvadore, G, Jacobs, GE

“…Background: Up to 40% of patients suffering from anxiety disorders do not benefit from currently available pharmacological treatments. Overactivity of the…”
Get full text

Hypothalamic glutamate levels following serotonergic stimulation: A pilot study using 7-Tesla magnetic resonance spectroscopy in healthy volunteers by Jacobs, G.E., der Grond, J. van, Teeuwisse, W.M., Langeveld, T.J.C., van Pelt, J., Verhagen, J.C.M., de Kam, M.L., Cohen, A.F., Zitman, F.G., van Gerven, J.M.A.

“…Functional proton magnetic resonance spectroscopy (MRS) can be applied to measure pharmacodynamic effects of central nervous system (CNS)-active drugs. The…”
Get full text

Desmopressin as a pharmacological tool in vasopressinergic hypothalamus–pituitary–adrenal axis modulation: neuroendocrine, cardiovascular and coagulatory effects by Jacobs, GE, Hulskotte, EGJ, van Gerven, JMA, Zuurman, L, de Kam, ML, Elassaiss-Schaap, J, Ruigt, G, van Pelt, J, Peeters, BWMM, Peeters, PAM, Burggraaf, J

“…Arginine-vasopressin (AVP) is a physiological co-activator of the hypothalamus–pituitary–adrenal (HPA) axis, together with corticotrophin releasing hormone…”
Get full text

A pharmacological tool to assess vasopressinergic co-activation of the hypothalamus–pituitary–adrenal axis more integrally in healthy volunteers by Jacobs, GE, van Gerven, JMA, de Kam, ML, Elassaiss-Schaap, J, Ruigt, G, van Pelt, J, Peeters, BWMM, Peeters, PAM, Hulskotte, EGJ

“…Pharmacological function tests consisting of 100 µg hCRH (corticorelin) and 10 µg dDAVP (desmopressin) mimic endogenous hypothalamus–pituitary–adrenal (HPA)…”
Get full text

Enhanced tolerability of the 5-hydroxytryptophane challenge test combined with granisetron by Jacobs, GE, Kamerling, IMC, de Kam, ML, DeRijk, RH, van Pelt, J., Zitman, FG, van Gerven, JMA

“…A recently developed oral serotonergic challenge test consisting of 5-Hydroxytryptophane (5-HTP, 200 mg) combined with carbidopa (CBD, 100 mg + 50 mg)…”
Get full text

Activation energies of intermetallic growth of Sn-Ag eutectic solder on copper substrates by FLANDERS, D. R, JACOBS, E. G, PINIZZOTTO, R. F

“…Intermetallic phases formed along a Sn-Ag eutectic solder/Cu interface during solid-state aging have been characterized, and the activation energies of Cu sub…”
Get full text

Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa by Smarius, LJCA, Jacobs, GE, Hoeberechts-Lefrandt, DHM, de Kam, ML, van der Post, JP, de Rijk, R, van Pelt, J, Schoemaker, RC, Zitman, FG, van Gerven, JMA, Gijsman, HJ

“…5-hydroxytryptophan (5-HTP) is a direct 5-hydroxytryptamine (5-HT) precursor used to assess central serotonergic function. Its use has been limited by a narrow…”
Get full text

Solving the crisis in psychopharmacological research: Cellular-membrane(s) pharmacology to the rescue? by Drukarch, B., Jacobs, G.E., Wilhelmus, M.M.M.

“…•Psychopharmacology is in crisis; its pipe-lines have dried up.•To solve the crisis and again fill the pipes “new lines of study” should be explored.•As such,…”
Get full text

Metoclopramide as pharmacological tool to assess vasopressinergic co-activation of the hypothalamus–pituitary–adrenal (HPA) axis: A study in healthy volunteers by Jacobs, G.E, Hulskotte, E.G.J, de Kam, M.L, Zha, G, Jiang, J, Hu, P, Zhao, Q, van Pelt, J, Goekoop, J.G, Zitman, F.G, van Gerven, J.M.A

“…Abstract The synthetic vasopressin (AVP) analogue desmopressin (dDAVP) has been used as pharmacological function test to quantify vasopressinergic…”
Get full text

Multicenter randomized controlled trial to evaluate the efficacy and tolerability of frozen gloves for the prevention of chemotherapy-induced peripheral neuropathy by Beijers, A.J.M., Bonhof, C.S., Mols, F., Ophorst, J., de Vos-Geelen, J., Jacobs, E.M.G., van de Poll-Franse, L.V., Vreugdenhil, G.

“…This study investigated the efficacy and tolerability of wearing frozen gloves (FGs) during chemotherapy to prevent chemotherapy-induced peripheral neuropathy…”
Get full text

Non-transferrin-bound iron is associated with plasma level of soluble intercellular adhesion molecule-1 but not with in vivo low-density lipoprotein oxidation by van Tits, L.J.H, Jacobs, E.M.G, Swinkels, D.W, Lemmers, H.L.M, van der Vleuten, G.M, de Graaf, J, Stalenhoef, A.F.H

“…Abstract Background Excess body iron is associated with increased cardiovascular disease risk, possibly via non-transferrin-bound iron (NTBI)-mediated…”
Get full text

The South London and Maudsley NHS Foundation Trust and Oxleas NHS Foundation Trust Prescribing Guidelines, 9th Edition by Jacobs, G. E., Cohen, A. F.

Get full text

Changing aspects of HFE-related hereditary haemochromatosis and endeavours to early diagnosis by JACOBS, E. M. G, VERBEEK, A. L. M, KREEFTENBERG, H. G, VAN DEURSEN, C. Th. B. M, MARX, J. J. M, STALENHOEF, A. F. H, SWINKELS, D. W, DE VRIES, R. A

“…HFE-related hereditary haemochromatosis (HH) is an iron overload disease attributed to the highly prevalent homozygosity for the C282Y mutation in the HFE…”
Get full text

Neonatal ovarian cysts by Vogtländer, MF, Rijntjes-Jacobs, EGJ, van den Hoonaard, ThL, Versteegh, FGA

“…Foetal and neonatal ovarian cysts have previously been considered uncommon. With the development of sonography, however, the detection of cysts has increased…”
Get full text

Responsibilities of the psychotherapy supervisor by WHITMAN, S. M, JACOBS, E. G

“…The art and skill of psychotherapy supervision and its teaching have received relatively little attention compared to their importance in psychiatric…”
Get full text

Birthweight distribution in southern Chinese infants with symptomatic congenital heart disease by Jacobs, EGJ, Leung, MP, Karlberg, LJ

“…Objective:  Western infants with congenital heart disease have frequently been reported to have a low birthweight for gestational age. Studies in Asian infants…”
Get full text

341 Acute effects of seltorexant, a selective orexin-2 antagonist (JNJ- 42847922), on driving after bedtime administration by Brooks, S, Zuiker, R G J A, Jacobs, G E, Kezic, I, Savitz, A, Van Der Ark, P D, Van Gerven, J M A

“…Abstract Introduction Seltorexant (JNJ-42847922), a potent and selective antagonist of the human orexin-2 receptor, is being developed for the treatment of…”
Get full text

P-V-T relations in a series of longitudinal polymer liquid crystals with varying mesogen concentration by Berry, James M., Brostow, Witold, Hess, Michael, Jacobs, Elizabeth G.

“…Pressure-volume-temperature (P-V-T) relationships were determined for polymer liquid crystal (PLC) solids and melts up to 400°C and 240 J cm −3. We have…”
Get full text

The formation and growth of intermetallics in composite solder by YUJING WU, SEES, J. A, POURAGHABAGHER, C, FOSTER, L. A, MARSHALL, J. L, JACOBS, E. G, PINIZZOTTO, R. F

Get full text

Low back pain outcome measurement assessment in chiropractic teaching clinics: responsiveness and applicability of two functional disability questionnaires by Haas, M, Jacobs, G E, Raphael, R, Petzing, K

“…The major aims were to evaluate responsiveness and clinical/research applicability of the Revised Oswestry Disability Questionnaire (ODQ) and the Dallas Pain…”
Get more information