Search Results - "JACOBS, B. R"

Pediatric Peripherally Inserted Central Catheters: Complication Rates Related to Catheter Tip Location by Racadio, John M, Doellman, Darcy A, Johnson, Neil D, Bean, Judy A, Jacobs, Brian R

“…To compare complication rates between central venous catheter tip location and noncentral tip location after peripherally inserted central catheter (PICC)…”
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Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD+ Recycling by Kim, Wondong, Deik, Amy, Gonzalez, Clicerio, Gonzalez, Maria Elena, Fu, Feifei, Ferrari, Michele, Churchhouse, Claire L., Florez, Jose C., Jacobs, Suzanne B.R., Clish, Clary B., Rhee, Eugene P.

“…The reactions catalyzed by the delta-5 and delta-6 desaturases (D5D/D6D), key enzymes responsible for highly unsaturated fatty acid (HUFA) synthesis,…”
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Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico by Williams, Amy L, Jacobs, Suzanne B R, Moreno-Macías, Hortensia, Huerta-Chagoya, Alicia, Churchhouse, Claire, Márquez-Luna, Carla, García-Ortíz, Humberto, Gómez-Vázquez, María José, Burtt, Noël P, Aguilar-Salinas, Carlos A, González-Villalpando, Clicerio, Florez, Jose C, Orozco, Lorena, Haiman, Christopher A, Tusié-Luna, Teresa, Altshuler, David

“…A risk haplotype for type 2 diabetes is identified with four amino acid substitutions in SLC16A11, which is present at ∼50% frequency in Native American…”
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Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms by Rusu, Victor, Hoch, Eitan, Mercader, Josep M., Tenen, Danielle E., Gymrek, Melissa, Hartigan, Christina R., DeRan, Michael, Guzman, Gaelen, Deik, Amy A., Pierce, Kerry A., Dennis, Courtney, Clish, Clary B., Carr, Steven A., Wagner, Bridget K., Chen, Brian H., Ng, Maggie C.Y., Chen, Brian H., Guo, Xiuqing, Liu, Jiankang, Bielinski, Suzette J., Nalls, Michael A., Rasmussen-Torvik, Laura J., Evans, Daniel S., Sun, Yan V., Patel, Sanjay R., Lu, Yingchang, Long, Jirong, Armstrong, Loren L., Yang, Lingyao, Snively, Beverly M., Palmer, Nicholette D., Mudgal, Poorva, Keene, Keith L., Freedman, Barry I., Goodarzi, Mark O., Correa, Adolfo, Sims, Mario, Couper, David, Pankow, James S., Boerwinkle, Eric, Adeyemo, Adebowale, Doumatey, Ayo, Vaidya, Dhananjay, Sedor, John R., Kabagambe, Edmond K., McKnight, Barbara, Rice, Kenneth, Bielak, Lawrence F., Gottesman, Omri, Cai, Qiuyin, Zheng, Wei, Blot, William J., Lowe, William L., Pacheco, Jennifer A., Crawford, Dana C., Rich, Stephen S., Shu, Xiao-Ou, Loos, Ruth J.F., Borecki, Ingrid B., Peyser, Patricia A., Fornage, Myriam, Evans, Michele K., Becker, Diane M., Kao, W.H. Linda, Wilson, James G., Sale, Michèle M., Liu, Simin, Rotimi, Charles N., Bowden, Donald W., Huerta-Chagoya, Alicia, Moreno-Macías, Hortensia, Manning, Alisa, Caulkins, Lizz, Burtt, Noël P., Flannick, Jason, Patterson, Nick, Tusié-Luna, Teresa, Altshuler, David, Florez, Jose C., Martínez-Hernández, Angélica, Centeno-Cruz, Federico, Zerrweck, Carlos, Contreras-Cubas, Cecilia, Córdova, Emilio, Soberón, Xavier, Orozco, Lorena, González-Villalpando, María Elena, Haiman, Christopher A., Le Marchand, Loic, Kolonel, Laurence, Rodríguez-Torres, Maribel, Segura-Kato, Yayoi, Rodríguez-Guillén, Rosario, Gómez, Donají, Alvirde, Ulices, Cortes, Maria L., Centeno-Cruz, Federico, Zerrweck, Carlos, Orozco, Lorena, Jacobs, Suzanne B.R.

“…Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that…”
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Nuclear Factor Y and Steroidogenic Factor 1 Physically and Functionally Interact to Contribute to Cell-Specific Expression of the Mouse Follicle-Stimulating Hormone-β Gene by Jacobs, Suzanne B. R, Coss, Djurdjica, McGillivray, Shauna M, Mellon, Pamela L

“…FSH is a heterodimeric glycoprotein hormone secreted from the gonadotrope cell population of the anterior pituitary. Despite its crucial role in mammalian…”
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Loss of the Desmosomal Component Perp Impairs Wound Healing In Vivo by Beaudry, Veronica G., Ihrie, Rebecca A., Jacobs, Suzanne B. R., Nguyen, Bichchau, Pathak, Navneeta, Park, Eunice, Attardi, Laura D.

“…Epithelial wound closure is a complex biological process that relies on the concerted action of activated keratinocytes and dermal fibroblasts to resurface and…”
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Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population by Estrada, Karol, Aukrust, Ingvild, Bjørkhaug, Lise, Burtt, Noël P, Mercader, Josep M, García-Ortiz, Humberto, Huerta-Chagoya, Alicia, Moreno-Macías, Hortensia, Walford, Geoffrey, Flannick, Jason, Williams, Amy L, Gómez-Vázquez, María J, Fernandez-Lopez, Juan C, Martínez-Hernández, Angélica, Centeno-Cruz, Federico, Mendoza-Caamal, Elvia, Revilla-Monsalve, Cristina, Islas-Andrade, Sergio, Córdova, Emilio J, Soberón, Xavier, González-Villalpando, María E, Henderson, E, Wilkens, Lynne R, Le Marchand, Loic, Arellano-Campos, Olimpia, Ordóñez-Sánchez, Maria L, Rodríguez-Torres, Maribel, Rodríguez-Guillén, Rosario, Riba, Laura, Najmi, Laeya A, Jacobs, Suzanne B.R, Fennell, Timothy, Gabriel, Stacey, Fontanillas, Pierre, Hanis, Craig L, Lehman, Donna M, Jenkinson, Christopher P, Abboud, Hanna E, Bell, Graeme I, Cortes, Maria L, Boehnke, Michael, González-Villalpando, Clicerio, Orozco, Lorena, Haiman, Christopher A, Tusié-Luna, Teresa, Aguilar-Salinas, Carlos A, Altshuler, David, Njølstad, Pål R, Florez, Jose C, MacArthur, Daniel G

“…IMPORTANCE Latino populations have one of the highest prevalences of type 2 diabetes worldwide. OBJECTIVES To investigate the association between rare…”
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Aerosolized soluble nitric oxide donor improves oxygenation and pulmonary hypertension in acute lung injury by JACOBS, B. R, BRILLI, R. J, BALLARD, E. T, PASSERINI, D. J, SMITH, D. I

“…Acute respiratory distress syndrome (ARDS) is a major cause of morbidity and mortality in critically ill patients. The associated ventilation/perfusion…”
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Reduction in Clinical Variance Using Targeted Design Changes in Computerized Provider Order Entry (CPOE) Order Sets: Impact on Hospitalized Children with Acute Asthma Exacerbation by Jacobs, B R, Hart, K W, Rucker, D W

“…Unwarranted variance in healthcare has been associated with prolonged length of stay, diminished health and increased cost. Practice variance in the management…”
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A Loss-of-Function Splice Acceptor Variant in IGF2 Is Protective for Type 2 Diabetes by Mercader, Josep M, Liao, Rachel G, Bell, Avery D, Dymek, Zachary, Estrada, Karol, Tukiainen, Taru, Huerta-Chagoya, Alicia, Moreno-Macías, Hortensia, Jablonski, Kathleen A, Hanson, Robert L, Walford, Geoffrey A, Moran, Ignasi, Chen, Ling, Agarwala, Vineeta, Ordoñez-Sánchez, María Luisa, Rodríguez-Guillen, Rosario, Rodríguez-Torres, Maribel, Segura-Kato, Yayoi, García-Ortiz, Humberto, Centeno-Cruz, Federico, Barajas-Olmos, Francisco, Caulkins, Lizz, Puppala, Sobha, Fontanillas, Pierre, Williams, Amy L, Bonàs-Guarch, Sílvia, Hartl, Chris, Ripke, Stephan, Tooley, Katherine, Lane, Jacqueline, Zerrweck, Carlos, Martínez-Hernández, Angélica, Córdova, Emilio J, Mendoza-Caamal, Elvia, Contreras-Cubas, Cecilia, González-Villalpando, María E, Cruz-Bautista, Ivette, Muñoz-Hernández, Liliana, Gómez-Velasco, Donaji, Alvirde, Ulises, Henderson, Brian E, Wilkens, Lynne R, Le Marchand, Loic, Arellano-Campos, Olimpia, Riba, Laura, Harden, Maegan, Gabriel, Stacey, Abboud, Hanna E, Cortes, Maria L, Revilla-Monsalve, Cristina, Islas-Andrade, Sergio, Soberon, Xavier, Curran, Joanne E, Jenkinson, Christopher P, DeFronzo, Ralph A, Lehman, Donna M, Hanis, Craig L, Bell, Graeme I, Boehnke, Michael, Blangero, John, Duggirala, Ravindranath, Saxena, Richa, MacArthur, Daniel, Ferrer, Jorge, McCarroll, Steven A, Torrents, David, Knowler, William C, Baier, Leslie J, Burtt, Noel, González-Villalpando, Clicerio, Haiman, Christopher A, Aguilar-Salinas, Carlos A, Tusié-Luna, Teresa, Flannick, Jason, Jacobs, Suzanne B R, Orozco, Lorena, Altshuler, David, Florez, Jose C

“…Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue to rise. To identify common or rare…”
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Siva plays a critical role in mouse embryonic development by Jacobs, Suzanne B. R., Van Nostrand, Jeanine L., Bowen, Margot E., Baker, Julie C., Attardi, Laura D.

“…The Siva protein, named after the Hindu God of Destruction, plays important roles in apoptosis in various contexts, including downstream of death receptor…”
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Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data by Hoch, Eitan, Florez, Jose C., Lander, Eric S., Jacobs, Suzanne B.R.

“…Human genetic variants in SLC16A11 are associated with increased risk of type 2 diabetes (T2D). We previously identified two distinct mechanisms through which…”
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Interaction Between Type 2 Diabetes Prevention Strategies and Genetic Determinants of Coronary Artery Disease on Cardiometabolic Risk Factors by Merino, Jordi, Jablonski, Kathleen A, Mercader, Josep M, Kahn, Steven E, Chen, Ling, Harden, Maegan, Delahanty, Linda M, Araneta, Maria Rosario G, Walford, Geoffrey A, Jacobs, Suzanne B R, Ibebuogu, Uzoma N, Franks, Paul W, Knowler, William C, Florez, Jose C

“…Coronary artery disease (CAD) is more frequent among individuals with dysglycemia. Preventive interventions for diabetes can improve cardiometabolic risk…”
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Unified computational model of transport in metal-insulating oxide-metal systems by Tierney, B. D., Hjalmarson, H. P., Jacobs-Gedrim, R. B., Agarwal, Sapan, James, C. D., Marinella, M. J.

“…A unified physics-based model of electron transport in metal-insulator-metal (MIM) systems is presented. In this model, transport through metal-oxide…”
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The SLC16A11 risk haplotype is associated with decreased insulin action, higher transaminases and large-size adipocytes by Almeda-Valdes, Paloma, Gómez Velasco, Donaji V, Arellano Campos, Olimpia, Bello-Chavolla, Omar Yaxmehen, del Rocío Sevilla-González, Magdalena, Viveros Ruiz, Tannia, Martagón Rosado, Alexandro J, Bautista, Claudia J, Muñoz Hernandez, Liliana, Cruz-Bautista, Ivette, Moreno-Macias, Hortensia, Huerta-Chagoya, Alicia, Rodríguez-Álvarez, Karen Guadalupe, Walford, Geoffrey A, Jacobs, Suzanne B R, Guillen Pineda, Luz E, Ordoñez-Sánchez, Ma Luisa, Roldan-Valadez, Ernesto, Azpiroz, Joaquín, Furuzawa-Carballeda, Jannette, Clark, Patricia, Herrera-Hernández, Miguel F, Zambrano, Elena, Florez, Jose C, Tusié Luna, María Teresa, Aguilar-Salinas, Carlos A

“…Objective A haplotype at chromosome 17p13 that reduces expression and function of the solute carrier transporter SLC16A11 is associated with increased risk for…”
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Analysis of TEST (TES and Tris) yolk buffer effects on human sperm by Jacobs, B R, Caulfield, J, Boldt, J

“…To assess different parameters of TEST (TES and Tris) yolk buffer (TYB) treatment of human sperm that may contribute to the biologic effects of TYB on sperm…”
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The p53 Target Gene SIVA Enables Non-Small Cell Lung Cancer Development by Van Nostrand, Jeanine L, Brisac, Alice, Mello, Stephano S, Jacobs, Suzanne B R, Luong, Richard, Attardi, Laura D

“…Although p53 transcriptional activation potential is critical for its ability to suppress cancer, the specific target genes involved in tumor suppression…”
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The Metastasis-Associated Gene Prl-3 Is a p53 Target Involved in Cell-Cycle Regulation by Basak, Shashwati, Jacobs, Suzanne B.R., Krieg, Adam J., Pathak, Navneeta, Zeng, Qi, Kaldis, Philipp, Giaccia, Amato J., Attardi, Laura D.

“…The p53 tumor suppressor restricts tumorigenesis through the transcriptional activation of target genes involved in cell-cycle arrest and apoptosis. Here, we…”
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Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock by Wheeler, D S, Lahni, P, Odoms, K, Jacobs, B R, Carcillo, J A, Doughty, L A, Wong, H R

“…Recent data suggest that extracellular Hsp60 modulates the host innate immune response. We analyzed plasma Hsp60 levels in children admitted to a level III…”
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Training a Neural Network on Analog TaO x ReRAM Devices Irradiated With Heavy Ions: Effects on Classification Accuracy Demonstrated With CrossSim by Jacobs-Gedrim, R. B., Hughart, D. R., Agarwal, S., Vizkelethy, G., Bielejec, E. S., Vaandrager, B. L., Swanson, S. E., Knisely, K. E., Taggart, J. L., Barnaby, H. J., Marinella, M. J.

“…The image classification accuracy of a TaO x ReRAM-based neuromorphic computing accelerator is evaluated after intentionally inducing a displacement damage up…”
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