Search Results - "JACOB, Gary S."

Deactivation of Akt and STAT3 signaling promotes apoptosis, inhibits proliferation, and enhances the sensitivity of hepatocellular carcinoma cells to an anticancer agent, Atiprimod by Choudhari, Sweeta R, Khan, Muhammad A, Harris, Genesis, Picker, Donald, Jacob, Gary S, Block, Timothy, Shailubhai, Kunwar

“…Atiprimod is a novel anticancer and antiangiogenic drug candidate which is currently being evaluated in patients with liver carcinoid and multiple myeloma. In…”
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Glycosylation inhibitors in biology and medicine by Jacob, Gary S

“…Glycosidase inhibitors are moving increasingly out of the laboratory and into the clinic as potential agents for the treatment of diseases including diabetes,…”
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A clinically relevant SCID-hu in vivo model of human multiple myeloma by Tassone, Pierfrancesco, Neri, Paola, Carrasco, Daniel R., Burger, Renate, Goldmacher, Victor S., Fram, Robert, Munshi, Vidit, Shammas, Masood A., Catley, Laurence, Jacob, Gary S., Venuta, Salvatore, Anderson, Kenneth C., Munshi, Nikhil C.

“…We developed a novel in vivo multiple myeloma (MM) model by engrafting the interleukin 6 (IL-6)-dependent human MM cell line INA-6 into severe combined…”
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Plecanatide, an Oral Guanylate Cyclase C Agonist Acting Locally in the Gastrointestinal Tract, Is Safe and Well-Tolerated in Single Doses by Shailubhai, Kunwar, Comiskey, Stephen, Foss, John A., Feng, Rong, Barrow, Laura, Comer, Gail M., Jacob, Gary S.

“…Purpose Plecanatide, an analogue of uroguanylin, activates the guanylate cyclase C (GC-C) receptor found on the GI mucosal epithelial cells, leading to…”
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Mo1316 Structural and Dynamic Features of Plecanatide: Insights From Molecular Dynamics Simulations by Brancale, Andrea, Shailubhai, Kunwar, Ferla, Salvatore, Ricci, Antonio, Bassetto, Marcella, Jacob, Gary S

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Therapeutically targeting guanylate cyclase‐C: computational modeling of plecanatide, a uroguanylin analog by Brancale, Andrea, Shailubhai, Kunwar, Ferla, Salvatore, Ricci, Antonio, Bassetto, Marcella, Jacob, Gary S

“…Plecanatide is a recently developed guanylate cyclase‐C (GC‐C) agonist and the first uroguanylin analog designed to treat chronic idiopathic constipation (CIC)…”
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967 Plecanatide, Like Uroguanylin, Activates Guanylate Cyclase-C Signaling in a pH-Dependent Manner in T84 Cells, and in Murine Intestinal Epithelial Cells and Tissues by Patwa, Viren, Joshi, Apoorva, Thadi, Anusha, Eddy, E. Priya, Palejwala, Vaseem A, Jacob, Gary S, Shailubhai, Kunwar

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925g Plecanatide, a Novel Guanylate Cyclase-C (GC-C) Receptor Agonist, is Efficacious and Safe in Patients with Chronic Idiopathic Constipation (CIC): Results from a 951 Patient, 12 Week, Multi-Center Trial by Miner, Philip B, Surowitz, Ron, Fogel, Ron, Koltun, William, Drossman, Douglas A, Camilleri, Michael, Mangel, Allen, Barrow, Laura, Jacob, Gary S, Shailubhai, Kunwar

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Binding of Sialyl Lewis X to E-Selectin As Measured by Fluorescence Polarization by Jacob, Gary S, Kirmaier, Christine, Abbas, S. Zaheer, Howard, Susan C, Steininger, Christina N, Welply, Joseph K, Scudder, Peter

“…Fluorescence polarization has been used to directly measure the binding of the tetrasaccharide sialyl Lewisx (sLe(x)[Glc], or NeuAc alpha 2-3Gal beta 1-4[Fuc…”
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W1041 SP-304 to Treat GI Disorders - Effects of a Single, Oral-Dose of SP-304 On Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers by Shailubhai, Kunwar, Gerson, William A, Talluto, Craig, Jacob, Gary S

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Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine) inhibits human multiple myeloma cell growth in the bone marrow milieu in vitro and in vivo by Hamasaki, Makoto, Hideshima, Teru, Tassone, Pierfrancesco, Neri, Paola, Ishitsuka, Kenji, Yasui, Hiroshi, Shiraishi, Norihiko, Raje, Noopur, Kumar, Shaji, Picker, Donald H., Jacob, Gary S., Richardson, Paul G., Munshi, Nikhil C., Anderson, Kenneth C.

“…Azaspirane (N-N-diethyl-8,8-dipropyl-2-azaspiro [4.5] decane-2-propanamine; trade name, Atiprimod) is an orally bioavailable cationic amphiphilic compound that…”
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Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis by Shailubhai, Kunwar, Palejwala, Vaseem, Arjunan, Krishna Priya, Saykhedkar, Sayali, Nefsky, Bradley, Foss, John A, Comiskey, Stephen, Jacob, Gary S, Plevy, Scott E

“…AIM: To evaluate the effect of orally administeredplecanatide or dolcanatide, analogs of uroguanylin, on amelioration of colitis in murine models.METHODS: The…”
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Treatment of chronic hepadnavirus infection in a woodchuck animal model with an inhibitor of protein folding and trafficking by Block, Timothy M, Lu, Xuanyong, Mehta, Anand S, Blumberg, Baruch S, Tennant, Bud, Ebling, Mathew, Korba, Brent, Lansky, David M, Jacob, Gary S, Dwek, Raymond A

“…A novel strategy for anti-viral intervention of hepatitis B virus (HBV) through the disruption of the proper folding and transport of the hepadnavirus…”
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Atiprimod is an inhibitor of cancer cell proliferation and angiogenesis by Shailubhai, Kunwar, Dheer, Surendra, Picker, Donald, Kaur, Gurmeet, Sausville, Edward A, Jacob, Gary S

“…Atiprimod, a novel compound belonging to the azaspirane class of cationic amphiphilic drugs, exhibits both anti-proliferative and anti-angiogenic activities…”
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Virulence of a phosphoribosylaminoimidazole carboxylase-deficient Candida albicans strain in an immunosuppressed murine model of systemic candidiasis by DONOVAN, Matthew, SCHUMUKE, Jon J, FONZI, William A, BONAR, Sheri L, GHEESLING-MULLIS, Karen, JACOB, Gary S, DAVISSON, Vincent Jo, DOTSON, Stanton B

“…The relative pathogenicities of three Candida albicans strains differing in the function of ADE2 (the gene encoding phosphoribosylaminoimidazole carboxylase)…”
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Catalase of Neurospora crassa. 1. Induction, purification, and physical properties by Jacob, Gary S, Orme-Johnson, W. H

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Inhibition of HIV replication by amino-sugar derivatives by Fleet, George W.J., Karpas, Abraham, Dwek, Raymond A., Fellows, Linda E., Tyms, A.S., Petursson, Sigthor, Namgoong, Sung K., Ramsden, Nigel G., Smith, Paul W., Son, Jong Chan, Wilson, Francis, Witty, David R., Jacob, Gary S., Rademacher, Thomas W.

“…The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti-HIV activity…”
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Aromatic Cross-Links in Insect Cuticle: Detection by Solid-State $^{13}$C and $^{15}$N NMR by Schaefer, Jacob, Kramer, Karl J., Garbow, Joel R., Jacob, Gary S., Stejskal, Edward O., Hopkins, Theodore L., Speirs, Roy D.

“…Cross-polarization magic-angle-spinning nuclear magnetic resonance spectroscopy has been used to determine insect cuticle composition and cross-link structure…”
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Multivalent sialyl-LeX: potent inhibitors of E-selectin-mediated cell adhesion; reagent for staining activated endothelial cells by Welply, J K, Abbas, S Z, Scudder, P, Keene, J L, Broschat, K, Casnocha, S, Gorka, C, Steininger, C, Howard, S C, Schmuke, J J

“…Free, monovalent, SLeX (Neu5Ac alpha 2-3Gal beta 1-4(Fuc alpha 1-3)-GlcNAc), SLn (Neu5Ac alpha 2-3Gal beta 1-4GlcNAc) and corresponding BSA-conjugated…”
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Purification and Characterization of a Lymph Node Sulfotransferase Responsible for 6-O-Sulfation of the Galactose Residues in 2′-Fucosyllactose and Other Sialyl LewisX-Related Sugars by Shailubhai, Kunwar, Khai Huynh, Q., Boddupalli, Hymavathi, Yu, Hong H., Jacob, Gary S.

“…A microsomal galactose-6-O-sulfotransferase (Gal-6-O-Stase) from porcine lymph nodes, able to transfer the sulfate group from adenosine 3′-phosphate…”
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