Search Results - "JACKSON, K"

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling by Mukhopadhyay, Saikat, Wen, Xiaohui, Ratti, Navneet, Loktev, Alexander, Rangell, Linda, Scales, Suzie J., Jackson, Peter K.

“…The primary cilium is required for Sonic hedgehog (Shh) signaling in vertebrates. In contrast to mutants affecting ciliary assembly, mutations in the…”
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Solidarity forever?: Toward a competitive market for organized labor by Jackson K Maxwell

“…Since the 1950s the major American labor unions have pursued a strategy of cooperation rather than competition. Under Article XX of the AFL-CIO Constitution…”
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The primary cilium as a cellular receiver: organizing ciliary GPCR signaling by Hilgendorf, Keren I, Johnson, Carl T, Jackson, Peter K

“…The primary cilium is an antenna-like cellular protrusion mediating sensory and neuroendocrine signaling. Its localization within tissue architecture and a…”
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A General Tool for Engineering the NAD/NADP Cofactor Preference of Oxidoreductases by Cahn, Jackson K. B, Werlang, Caroline A, Baumschlager, Armin, Brinkmann-Chen, Sabine, Mayo, Stephen L, Arnold, Frances H

“…The ability to control enzymatic nicotinamide cofactor utilization is critical for engineering efficient metabolic pathways. However, the complex interactions…”
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Chromothripsis from DNA damage in micronuclei by Zhang, Cheng-Zhong, Spektor, Alexander, Cornils, Hauke, Francis, Joshua M., Jackson, Emily K., Liu, Shiwei, Meyerson, Matthew, Pellman, David

“…Genome sequencing has uncovered a new mutational phenomenon in cancer and congenital disorders called chromothripsis. Chromothripsis is characterized by…”
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Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble by Buller, Andrew R, van Roye, Paul, Cahn, Jackson K. B, Scheele, Remkes A, Herger, Michael, Arnold, Frances H

“…Allosteric enzymes contain a wealth of catalytic diversity that remains distinctly underutilized for biocatalysis. Tryptophan synthase is a model allosteric…”
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Neuropeptide Y Family Receptors Traffic via the Bardet-Biedl Syndrome Pathway to Signal in Neuronal Primary Cilia by Loktev, Alexander V., Jackson, Peter K.

“…Human monogenic obesity syndromes, including Bardet-Biedl syndrome (BBS), implicate neuronal primary cilia in regulation of energy homeostasis. Cilia in…”
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Group structure and individual relationships of sanctuary-living Grauer's gorillas (Gorilla beringei graueri) by Leeds, Austin, Kakule, Dalmas, Stalter, Laura, Mbeke, Jackson K, Fawcett, Katie

“…The study of individual social relationships and group structure provides insights into a species' natural history and can inform management decisions for…”
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Application of the anatomical chemical system/defined daily doses: Challenges and way forward for resource‐limited countries by Nantongo, Hanifah, Batwaala, Vincent, Nambasa, Victoria, Mukonzo, Jackson K.

“…What is known and objective The Anatomical Therapeutic Chemical Classification/Defined Daily Doses (ATC/DDD) methodology is a WHO gold standard for ensuring…”
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Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications by Zhang, Hongbin, Jackson, John K., Chiao, Mu

“…Microfabrication technology has enabled the development of novel controlled‐release devices that possess an integration of structural, mechanical, and perhaps…”
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4S‑Hydroxylation of Insulin at ProB28 Accelerates Hexamer Dissociation and Delays Fibrillation by Lieblich, Seth A, Fang, Katharine Y, Cahn, Jackson K. B, Rawson, Jeffrey, LeBon, Jeanne, Ku, H. Teresa, Tirrell, David A

“…Daily injections of insulin provide lifesaving benefits to millions of diabetics. But currently available prandial insulins are suboptimal: The onset of action…”
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Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models by Dodani, Sheel C., Kiss, Gert, Cahn, Jackson K. B., Su, Ye, Pande, Vijay S., Arnold, Frances H.

“…The dynamic motions of protein structural elements, particularly flexible loops, are intimately linked with diverse aspects of enzyme catalysis. Engineering of…”
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Alternative preprocessing of RNA-Sequencing data in The Cancer Genome Atlas leads to improved analysis results by Rahman, Mumtahena, Jackson, Laurie K, Johnson, W Evan, Li, Dean Y, Bild, Andrea H, Piccolo, Stephen R

“…The Cancer Genome Atlas (TCGA) RNA-Sequencing data are used widely for research. TCGA provides 'Level 3' data, which have been processed using a pipeline…”
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Opening up the Single‐Cell Toolbox for Microbial Natural Products Research by Cahn, Jackson K. B., Piel, Jörn

“…The diverse microbes that produce natural products represent an important source of novel therapeutics, drug leads, and scientific tools. However, the vast…”
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Estradiol Metabolism: Crossroads in Pulmonary Arterial Hypertension by Tofovic, Stevan P, Jackson, Edwin K

“…Pulmonary arterial hypertension (PAH) is a debilitating and progressive disease that predominantly develops in women. Over the past 15 years, cumulating…”
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A comparative study of logistic regression based machine learning techniques for prediction of early virological suppression in antiretroviral initiating HIV patients by Bisaso, Kuteesa R, Karungi, Susan A, Kiragga, Agnes, Mukonzo, Jackson K, Castelnuovo, Barbara

“…Treatment with effective antiretroviral therapy (ART) lowers morbidity and mortality among HIV positive individuals. Effective highly active antiretroviral…”
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Avian mercury exposure and toxicological risk across western North America: A synthesis by Ackerman, Joshua T., Eagles-Smith, Collin A., Herzog, Mark P., Hartman, C. Alex, Peterson, Sarah H., Evers, David C., Jackson, Allyson K., Elliott, John E., Vander Pol, Stacy S., Bryan, Colleen E.

“…Methylmercury contamination of the environment is an important issue globally, and birds are useful bioindicators for mercury monitoring programs. The…”
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Immunological mechanisms of the antitumor effects of supplemental oxygenation by Hatfield, Stephen M, Kjaergaard, Jorgen, Lukashev, Dmitriy, Schreiber, Taylor H, Belikoff, Bryan, Abbott, Robert, Sethumadhavan, Shalini, Philbrook, Phaethon, Ko, Kami, Cannici, Ryan, Thayer, Molly, Rodig, Scott, Kutok, Jeffrey L, Jackson, Edwin K, Karger, Barry, Podack, Eckhard R, Ohta, Akio, Sitkovsky, Michail V

“…Antitumor T cells either avoid or are inhibited in hypoxic and extracellular adenosine-rich tumor microenvironments (TMEs) by A2A adenosine receptors. This may…”
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A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds by Moosmann, Philipp, Ecker, Felix, Leopold-Messer, Stefan, Cahn, Jackson K. B., Dieterich, Cora L., Groll, Michael, Piel, Jörn

“…Class II terpene cyclases, such as oxidosqualene and squalene-hopene cyclases, catalyse some of the most complex polycyclization reactions. They minimally…”
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CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities by Han, Kyuho, Pierce, Sarah E., Li, Amy, Spees, Kaitlyn, Anderson, Gray R., Seoane, Jose A., Lo, Yuan-Hung, Dubreuil, Michael, Olivas, Micah, Kamber, Roarke A., Wainberg, Michael, Kostyrko, Kaja, Kelly, Marcus R., Yousefi, Maryam, Simpkins, Scott W., Yao, David, Lee, Keonil, Kuo, Calvin J., Jackson, Peter K., Sweet-Cordero, Alejandro, Kundaje, Anshul, Gentles, Andrew J., Curtis, Christina, Winslow, Monte M., Bassik, Michael C.

“…Cancer genomics studies have identified thousands of putative cancer driver genes 1 . Development of high-throughput and accurate models to define the…”
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