Search Results - "JACKSON, Colin"

Ranking the biases: The choice of OTUs vs. ASVs in 16S rRNA amplicon data analysis has stronger effects on diversity measures than rarefaction and OTU identity threshold by Chiarello, Marlène, McCauley, Mark, Villéger, Sébastien, Jackson, Colin R

“…Advances in the analysis of amplicon sequence datasets have introduced a methodological shift in how research teams investigate microbial biodiversity, away…”
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Microbiome evolution along divergent branches of the vertebrate tree of life: what is known and unknown by Colston, Timothy J., Jackson, Colin R.

“…Vertebrates harbour microbes both internally and externally, and collectively, these microorganisms (the ‘microbiome’) contain genes that outnumber the host's…”
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Rapid transition from primary to secondary crust building on the Moon explained by mantle overturn by Prissel, Tabb C., Zhang, Nan, Jackson, Colin R. M., Li, Haoyuan

“…Geochronology indicates a rapid transition (tens of Myrs) from primary to secondary crust building on the Moon. The processes responsible for initiating…”
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Early episodes of high-pressure core formation preserved in plume mantle by Jackson, Colin R. M., Bennett, Neil R., Du, Zhixue, Cottrell, Elizabeth, Fei, Yingwei

“…Xenon isotopic anomalies found in modern plume rocks are explained as the result of iodine-to-plutonium fractionations during early, high-pressure episodes of…”
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Nitrogen partitioning between silicate phases and aqueous fluid depends on concentration by Jackson, Colin R.M., Cottrell, Elizabeth

“…The distribution of nitrogen in geologic systems is modulated by its partitioning between silicate (mineral and melt) and fluid phases. Under geologically…”
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Ancestral Protein Reconstruction Yields Insights into Adaptive Evolution of Binding Specificity in Solute-Binding Proteins by Clifton, Ben E, Jackson, Colin J

“…The promiscuous functions of proteins are an important reservoir of functional novelty in protein evolution, but the molecular basis for binding promiscuity…”
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The gut microbiome of freshwater Unionidae mussels is determined by host species and is selectively retained from filtered seston by Weingarten, Eric A, Atkinson, Carla L, Jackson, Colin R

“…Freshwater mussels are a species-rich group of aquatic invertebrates that are among the most endangered groups of fauna worldwide. As filter-feeders that are…”
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Ancestral sequence reconstruction for protein engineers by Spence, Matthew A., Kaczmarski, Joe A., Saunders, Jake W., Jackson, Colin J.

“…In addition to its value in the study of molecular evolution, ancestral sequence reconstruction (ASR) has emerged as a useful methodology for engineering…”
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Readability in the Canadian tax system by Jackson, Colin

“…This paper reports the results of a readability analysis of various parts of the Canadian tax system, with a particular focus on Canada's income tax. The…”
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Warm and oxidizing slabs limit ingassing efficiency of nitrogen to the mantle by Jackson, Colin R.M., Cottrell, Elizabeth, Andrews, Ben

“…•Biotite-rhyolitic melt-hydrous fluid partitioning of N is reported for slab dehydration and melting conditions.•High pressure and reducing conditions limit N…”
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The role of protein dynamics in the evolution of new enzyme function by Campbell, Eleanor, Kaltenbach, Miriam, Correy, Galen J, Carr, Paul D, Porebski, Benjamin T, Livingstone, Emma K, Afriat-Jurnou, Livnat, Buckle, Ashley M, Weik, Martin, Hollfelder, Florian, Tokuriki, Nobuhiko, Jackson, Colin J

“…Analysis of the structures and dynamics of intermediates and engineered mutants from directed protein evolution experiments reveals how dynamic conformational…”
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Culture dependent and independent analysis of bacterial communities associated with commercial salad leaf vegetables by Jackson, Colin R, Randolph, Kevin C, Osborn, Shelly L, Tyler, Heather L

“…Plants harbor a diverse bacterial community, both as epiphytes on the plant surface and as endophytes within plant tissue. While some plant-associated bacteria…”
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Phylogenetic Analysis of Bacterial Communities in Different Regions of the Gastrointestinal Tract of Agkistrodon piscivorus, the Cottonmouth Snake by Colston, Timothy J, Noonan, Brice P, Jackson, Colin R

“…Vertebrates are metagenomic organisms in that they are composed not only of their own genes but also those of their associated microbial cells. The majority of…”
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LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia by Henneberger, Christian, Bard, Lucie, Panatier, Aude, Reynolds, James P., Kopach, Olga, Medvedev, Nikolay I., Minge, Daniel, Herde, Michel K., Anders, Stefanie, Kraev, Igor, Heller, Janosch P., Rama, Sylvain, Zheng, Kaiyu, Jensen, Thomas P., Sanchez-Romero, Inmaculada, Jackson, Colin J., Janovjak, Harald, Ottersen, Ole Petter, Nagelhus, Erlend Arnulf, Oliet, Stephane H.R., Stewart, Michael G., Nägerl, U. Valentin, Rusakov, Dmitri A.

“…Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by perisynaptic astroglial processes (PAPs): this helps maintain…”
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Diminishing returns and tradeoffs constrain the laboratory optimization of an enzyme by Tokuriki, Nobuhiko, Jackson, Colin J., Afriat-Jurnou, Livnat, Wyganowski, Kirsten T., Tang, Renmei, Tawfik, Dan S.

“…Optimization processes, such as evolution, are constrained by diminishing returns—the closer the optimum, the smaller the benefit per mutation, and by…”
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Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase by Chan, Kai Xun, Mabbitt, Peter D., Phua, Su Yin, Mueller, Jonathan W., Nisar, Nazia, Gigolashvili, Tamara, Stroeher, Elke, Grassl, Julia, Arlt, Wiebke, Estavillo, Gonzalo M., Jackson, Colin J., Pogson, Barry J.

“…Intracellular signaling during oxidative stress is complex, with organelle-to-nucleus retrograde communication pathways ill-defined or incomplete. Here we…”
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Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering by Lee, Brendon M, Harold, Liam K, Almeida, Deepak V, Afriat-Jurnou, Livnat, Aung, Htin Lin, Forde, Brian M, Hards, Kiel, Pidot, Sacha J, Ahmed, F Hafna, Mohamed, A Elaaf, Taylor, Matthew C, West, Nicholas P, Stinear, Timothy P, Greening, Chris, Beatson, Scott A, Nuermberger, Eric L, Cook, Gregory M, Jackson, Colin J

“…Our inability to predict which mutations could result in antibiotic resistance has made it difficult to rapidly identify the emergence of resistance, identify…”
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A Comprehensive Phylogenetic Analysis of the Serpin Superfamily by Spence, Matthew A, Mortimer, Matthew D, Buckle, Ashley M, Minh, Bui Quang, Jackson, Colin J

“…Abstract Serine protease inhibitors (serpins) are found in all kingdoms of life and play essential roles in multiple physiological processes. Owing to the…”
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Laboratory evolution of protein conformational dynamics by Campbell, Eleanor C, Correy, Galen J, Mabbitt, Peter D, Buckle, Ashley M, Tokuriki, Nobuhiko, Jackson, Colin J

“…•Laboratory directed evolution and ancestral reconstruction can facilitate study of protein structural dynamics.•Advances in biophysical and computational…”
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Physiology, Biochemistry, and Applications of F420- and Fo-Dependent Redox Reactions by Greening, Chris, Ahmed, F Hafna, Mohamed, A Elaaf, Lee, Brendon M, Pandey, Gunjan, Warden, Andrew C, Scott, Colin, Oakeshott, John G, Taylor, Matthew C, Jackson, Colin J

“…5-Deazaflavin cofactors enhance the metabolic flexibility of microorganisms by catalyzing a wide range of challenging enzymatic redox reactions. While…”
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