Search Results - "JACKS, Tyler"

PKM2, cancer metabolism, and the road ahead by Dayton, Talya L, Jacks, Tyler, Vander Heiden, Matthew G

“…A major metabolic aberration associated with cancer is a change in glucose metabolism. Isoform selection of the glycolytic enzyme pyruvate kinase has been…”
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MicroRNAs and Cancer: Short RNAs Go a Long Way by Ventura, Andrea, Jacks, Tyler

“…MicroRNAs (miRNAs) may be important regulators of gene expression. By modulating oncogenic and tumor suppressor pathways they could, in principle, contribute…”
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Applications of the CRISPR–Cas9 system in cancer biology by Sánchez-Rivera, Francisco J., Jacks, Tyler

“…The CRISPR–Cas9 (clustered regularly interspaced short palindromic repeats–CRISPR-associated 9) system provides many avenues for improving how we generate…”
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Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6 by Lee, Joo-Hyeon, Tammela, Tuomas, Hofree, Matan, Choi, Jinwook, Marjanovic, Nemanja Despot, Han, Seungmin, Canner, David, Wu, Katherine, Paschini, Margherita, Bhang, Dong Ha, Jacks, Tyler, Regev, Aviv, Kim, Carla F.

“…The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and regeneration is poorly defined. We used genetic lineage tracing,…”
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Circadian Rhythm Disruption Promotes Lung Tumorigenesis by Papagiannakopoulos, Thales, Bauer, Matthew R., Davidson, Shawn M., Heimann, Megan, Subbaraj, Lakshmipriya, Bhutkar, Arjun, Bartlebaugh, Jordan, Vander Heiden, Matthew G., Jacks, Tyler

“…Circadian rhythms are 24-hr oscillations that control a variety of biological processes in living systems, including two hallmarks of cancer, cell division and…”
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CRISPR-mediated direct mutation of cancer genes in the mouse liver by Xue, Wen, Chen, Sidi, Yin, Hao, Tammela, Tuomas, Papagiannakopoulos, Thales, Joshi, Nikhil S., Cai, Wenxin, Yang, Gillian, Bronson, Roderick, Crowley, Denise G., Zhang, Feng, Anderson, Daniel G., Sharp, Phillip A., Jacks, Tyler

“…CRISPR plasmids targeting Pten and p53 , alone and in combination, are delivered by hydrodynamic injection to the liver; the CRISPR-mediated mutations…”
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A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies by Boettcher, Steffen, Miller, Peter G, Sharma, Rohan, McConkey, Marie, Leventhal, Matthew, Krivtsov, Andrei V, Giacomelli, Andrew O, Wong, Waihay, Kim, Jesi, Chao, Sherry, Kurppa, Kari J, Yang, Xiaoping, Milenkowic, Kirsten, Piccioni, Federica, Root, David E, Rücker, Frank G, Flamand, Yael, Neuberg, Donna, Lindsley, R Coleman, Jänne, Pasi A, Hahn, William C, Jacks, Tyler, Döhner, Hartmut, Armstrong, Scott A, Ebert, Benjamin L

“…, which encodes the tumor suppressor p53, is the most frequently mutated gene in human cancer. The selective pressures shaping its mutational spectrum,…”
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Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer by Raghavan, Srivatsan, Winter, Peter S., Navia, Andrew W., Williams, Hannah L., DenAdel, Alan, Lowder, Kristen E., Galvez-Reyes, Jennyfer, Kalekar, Radha L., Mulugeta, Nolawit, Kapner, Kevin S., Raghavan, Manisha S., Borah, Ashir A., Liu, Nuo, Väyrynen, Sara A., Costa, Andressa Dias, Ng, Raymond W.S., Wang, Junning, Hill, Emma K., Ragon, Dorisanne Y., Brais, Lauren K., Jaeger, Alex M., Spurr, Liam F., Li, Yvonne Y., Cherniack, Andrew D., Booker, Matthew A., Cohen, Elizabeth F., Tolstorukov, Michael Y., Wakiro, Isaac, Rotem, Asaf, Johnson, Bruce E., McFarland, James M., Sicinska, Ewa T., Jacks, Tyler E., Sullivan, Ryan J., Shapiro, Geoffrey I., Clancy, Thomas E., Perez, Kimberly, Rubinson, Douglas A., Ng, Kimmie, Cleary, James M., Crawford, Lorin, Manalis, Scott R., Nowak, Jonathan A., Wolpin, Brian M., Hahn, William C., Aguirre, Andrew J., Shalek, Alex K.

“…Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of their drivers, stability, and…”
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Survival of pancreatic cancer cells lacking KRAS function by Muzumdar, Mandar Deepak, Chen, Pan-Yu, Dorans, Kimberly Judith, Chung, Katherine Minjee, Bhutkar, Arjun, Hong, Erin, Noll, Elisa M., Sprick, Martin R., Trumpp, Andreas, Jacks, Tyler

“…Activating mutations in the proto-oncogene KRAS are a hallmark of pancreatic ductal adenocarcinoma (PDAC), an aggressive malignancy with few effective…”
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Characterizing deformability and surface friction of cancer cells by Byun, Sangwon, Son, Sungmin, Amodei, Dario, Cermak, Nathan, Shaw, Josephine, Kang, Joon Ho, Hecht, Vivian C., Winslow, Monte M., Jacks, Tyler, Mallick, Parag, Manalis, Scott R.

“…Metastasis requires the penetration of cancer cells through tight spaces, which is mediated by the physical properties of the cells as well as their…”
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Autophagy is required for glucose homeostasis and lung tumor maintenance by Karsli-Uzunbas, Gizem, Guo, Jessie Yanxiang, Price, Sandy, Teng, Xin, Laddha, Saurabh V, Khor, Sinan, Kalaany, Nada Y, Jacks, Tyler, Chan, Chang S, Rabinowitz, Joshua D, White, Eileen

“…Macroautophagy (autophagy hereafter) recycles intracellular components to sustain mitochondrial metabolism that promotes the growth, stress tolerance, and…”
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Colonoscopy-based colorectal cancer modeling in mice with CRISPR–Cas9 genome editing and organoid transplantation by Roper, Jatin, Tammela, Tuomas, Akkad, Adam, Almeqdadi, Mohammad, Santos, Sebastian B, Jacks, Tyler, Yilmaz, Ömer H

“…Colonoscopy-guided mucosal injection is used to induce site-directed tumors and to transplant tumors into the distal colons of mice. Tumors for engraftment are…”
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Impaired microRNA processing enhances cellular transformation and tumorigenesis by Jacks, Tyler, Kumar, Madhu S, Lu, Jun, Mercer, Kim L, Golub, Todd R

“…MicroRNAs (miRNAs) are a new class of small noncoding RNAs that post-transcriptionally regulate the expression of target mRNA transcripts. Many of these target…”
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Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution by Yang, Dian, Jones, Matthew G., Naranjo, Santiago, Rideout, William M., Min, Kyung Hoi (Joseph), Ho, Raymond, Wu, Wei, Replogle, Joseph M., Page, Jennifer L., Quinn, Jeffrey J., Horns, Felix, Qiu, Xiaojie, Chen, Michael Z., Freed-Pastor, William A., McGinnis, Christopher S., Patterson, David M., Gartner, Zev J., Chow, Eric D., Bivona, Trever G., Chan, Michelle M., Yosef, Nir, Jacks, Tyler, Weissman, Jonathan S.

“…Tumor evolution is driven by the progressive acquisition of genetic and epigenetic alterations that enable uncontrolled growth and expansion to neighboring and…”
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A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma by Tammela, Tuomas, Sanchez-Rivera, Francisco J., Cetinbas, Naniye Malli, Wu, Katherine, Joshi, Nikhil S., Helenius, Katja, Park, Yoona, Azimi, Roxana, Kerper, Natanya R., Wesselhoeft, R. Alexander, Gu, Xin, Schmidt, Leah, Cornwall-Brady, Milton, Yilmaz, Ömer H., Xue, Wen, Katajisto, Pekka, Bhutkar, Arjun, Jacks, Tyler

“…A subset of Kras and p53 mutant cancer cells acts as a Wnt-producing niche for another cancer cell subset, and porcupine inhibition disrupts Wnt secretion in…”
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Driving Rel-iant Tregs toward an Identity Crisis by Li, Amy, Jacks, Tyler

“…Inhibiting Treg cell function in tumors is an attractive strategy to improve anti-cancer immunity. In a pair of papers in Immunity and Cell, Ghosh and…”
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Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer by Davidson, Shawn M., Papagiannakopoulos, Thales, Olenchock, Benjamin A., Heyman, Julia E., Keibler, Mark A., Luengo, Alba, Bauer, Matthew R., Jha, Abhishek K., O’Brien, James P., Pierce, Kerry A., Gui, Dan Y., Sullivan, Lucas B., Wasylenko, Thomas M., Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Mott, Bryan T., Jacks, Tyler, Clish, Clary B., Vander Heiden, Matthew G.

“…Cultured cells convert glucose to lactate, and glutamine is the major source of tricarboxylic acid (TCA)-cycle carbon, but whether the same metabolic phenotype…”
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Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma by Mazur, Pawel K, Herner, Alexander, Mello, Stephano S, Wirth, Matthias, Hausmann, Simone, Sánchez-Rivera, Francisco J, Lofgren, Shane M, Kuschma, Timo, Hahn, Stephan A, Vangala, Deepak, Trajkovic-Arsic, Marija, Gupta, Aayush, Heid, Irina, Noël, Peter B, Braren, Rickmer, Erkan, Mert, Kleeff, Jörg, Sipos, Bence, Sayles, Leanne C, Heikenwalder, Mathias, Heßmann, Elisabeth, Ellenrieder, Volker, Esposito, Irene, Jacks, Tyler, Bradner, James E, Khatri, Purvesh, Sweet-Cordero, E Alejandro, Attardi, Laura D, Schmid, Roland M, Schneider, Guenter, Sage, Julien, Siveke, Jens T

“…The bromodomain and extraterminal (BET) inhibitor JQ1 synergizes with the histone deacetylase inhibitor SAHA to suppress tumor growth in mouse models of…”
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A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response by Huarte, Maite, Guttman, Mitchell, Feldser, David, Garber, Manuel, Koziol, Magdalena J., Kenzelmann-Broz, Daniela, Khalil, Ahmad M., Zuk, Or, Amit, Ido, Rabani, Michal, Attardi, Laura D., Regev, Aviv, Lander, Eric S., Jacks, Tyler, Rinn, John L.

“…Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus…”
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Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium by Pentinmikko, Nalle, Iqbal, Sharif, Mana, Miyeko, Andersson, Simon, Cognetta, Armand B., Suciu, Radu M., Roper, Jatin, Luopajärvi, Kalle, Markelin, Eino, Gopalakrishnan, Swetha, Smolander, Olli-Pekka, Naranjo, Santiago, Saarinen, Tuure, Juuti, Anne, Pietiläinen, Kirsi, Auvinen, Petri, Ristimäki, Ari, Gupta, Nitin, Tammela, Tuomas, Jacks, Tyler, Sabatini, David M., Cravatt, Benjamin F., Yilmaz, Ömer H., Katajisto, Pekka

“…A decline in stem cell function impairs tissue regeneration during ageing, but the role of the stem-cell-supporting niche in ageing is not well understood. The…”
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