Search Results - "J.S., Hoffmann"

Adaptation to DNA damage and stimulation of genetic instability: the double-edged sword mammalian DNA polymerase κ by Bavoux, C., Hoffmann, J.S., Cazaux, C.

“…A major tolerance mechanism that functions to replicate damaged genomic DNA across lesions that have escaped elimination by repair mechanism is translesion DNA…”
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Modulation of cellular response to cisplatin by a novel inhibitor of DNA polymerase beta by Boudsocq, F, Benaim, P, Canitrot, Y, Knibiehler, M, Ausseil, F, Capp, J P, Bieth, A, Long, C, David, B, Shevelev, I, Frierich-Heinecken, E, Hübscher, U, Amalric, F, Massiot, G, Hoffmann, J S, Cazaux, C

“…DNA polymerase beta (Pol beta) is an error-prone enzyme whose up-regulation has been shown to be a genetic instability enhancer as well as a contributor to…”
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In vivo gene silencing in solid tumors by targeted electrically mediated siRNA delivery by GOLZIO, M, MAZZOLINI, L, COUDERC, B, TEISSIE, J, LEDOUX, A, PAGANIN, A, IZARD, M, HELLAUDAIS, L, BIETH, A, PILLAIRE, M. J, CAZAUX, C, HOFFMANN, J. S

“…RNA interference (RNAi)-mediated gene silencing approaches appear very promising for therapies based on the targeted inhibition of disease-relevant genes. The…”
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Up-regulation of the error-prone DNA polymerase Β promotes pleiotropic genetic alterations and tumorigenesis by Bavoux, C., A.M., Leopoldino, Bergoglio, V., O-Wang, J., Ogi, T., Bieth, A., S.D.J., Pena, M.F, Poupon, Helleday, T., Tagawa, M., C.R., Machado, J.S., Hoffmann, Cazaux, C.

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New Acylphloroglucinol Derivatives from Mahurea palustris by Massiot, G., Long, C., David, B., M.J., Serrano, Daubié, F., Alby, F., Ausseil, F., Knibiehler, M., Moretti, C., J.S., Hoffmann, Cazaux, C., Lavaud, C.

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R66: Rôle de l’ADN polymérase thêta dans le maintien de l’intégrité du génome en absence de stress exogène by Fernandez-Vidal, A., Magdeleine, E., Wood, R.D., Cazaux, C., Hoffmann, J.S.

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Isolation and characterization of HC1: a novel human DNA repair gene by Lopes, D O, Falconi, F C, Goes, A M, Canitrot, Y, Hoffmann, J S, Cazaux, C, Franco, G R, Macedo, A M, Pena, S D J, Machado, C R

“…Nucleotide excision repair (NER) acts on a broad spectrum of large lesions, while base excision repair removes individual modified bases. Although both…”
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R75: Caractérisation du rôle de l’ADN polymérase alternative kappa (Pol k) dans le checkpoint de la phase S by Pillaire, M.J., Thibault-Steinmetz, K., Bétous, R., Recolin, B., Guo, C., Bieth, A., Chartrain, M., Niimi, N., Gruz, P., Nohmi, T., Maiorano, D., Friedberg, E., Cazaux, C., Hoffmann, J.S.

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Replication of DNA containing cisplatin lesions and its mutagenic consequences by Pillaire, M.J., Hoffmann, J.S., Defais, M., Villani, G.

“…Cisplatin [ cis-diamminedichloroplatinum II] is widely used in the treatment of a broad range of tumors. A number of biological and biochemical results…”
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