Search Results - "J.B. Marks, Daniel"

Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease by Smith, Andrew M, Rahman, Farooq Z, Hayee, Bu'Hussain, Graham, Simon J, Marks, Daniel J B, Sewell, Gavin W, Palmer, Christine D, Wilde, Jonathan, Foxwell, Brian M J, Gloger, Israel S, Sweeting, Trevor, Marsh, Mark, Walker, Ann P, Bloom, Stuart L, Segal, Anthony W

“…The cause of Crohn's disease (CD) remains poorly understood. Counterintuitively, these patients possess an impaired acute inflammatory response, which could…”
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Resistant Hypertension: Trials and Tribulations by George, Marc J, Marks, Daniel J.B, Rezk, Tamer, Breckenridge, Ross, Sofat, Reecha, Martin, John, MacAllister, Raymond, Touyz, Rhian M, Staessen, Jan A, Bursztyn, Michael, Lappin, David, Barigou, Mohammed, Hingorani, Aroon

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Crohn's Disease: an Immune Deficiency State by Marks, Daniel J. B, Rahman, Farooq Z, Sewell, Gavin W, Segal, Anthony W

“…Crohn's disease is a chronic inflammatory disorder primarily affecting the gastrointestinal tract. Its clinical manifestations arise from a substantial…”
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Severe alkalosis and hypokalemia with stanozolol misuse by Maini, Alexander A.N., MA (Cantab), MB, BS, Maxwell-Scott, Hector, BM, BS, MSc, Marks, Daniel J.B., PhD

“…Stanozolol is a popular androgenic anabolic steroid, used by body builders and athletes for physical performance enhancement. There are few data on its…”
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A randomised, double‐blind, placebo‐controlled study of the LAG‐3‐depleting monoclonal antibody GSK2831781 in patients with active ulcerative colitis by D'Haens, Geert, Peyrin‐Biroulet, Laurent, Marks, Daniel J. B., Lisi, Edoardo, Liefaard, Lia, Beaton, Andrew, Srinivasan, Naren, Bouma, Gerben, Prasad, Naveen, Cameron, Raymond, Kayali, Zeid, Tarzi, Ruth, Hanauer, Stephen, Sandborn, William J.

“…Summary Background Selective depletion of T cells expressing LAG‐3, an immune checkpoint receptor that is upregulated on activated T cells, has been…”
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Depletion of LAG‐3+ T Cells Translated to Pharmacology and Improvement in Psoriasis Disease Activity: A Phase I Randomized Study of mAb GSK2831781 by Ellis, Joanne, J.B. Marks, Daniel, Srinivasan, Naren, Barrett, Christine, Hopkins, Thomas G., Richards, Anna, Fuhr, Rainard, Albayaty, Muna, Coenen, Martin, Liefaard, Lia, Leavens, Karen, Nevin, Katherine L., Tang, Shuo, Hughes, Stephen A., Fortunato, Léa, Edwards, Ken, Cui, Yi, Anselm, Rabia, Delves, Christopher J., Charles, Emilie, Feeney, Maria, Webb, Thomas M., Brett, Sara J., Schmidt, Tim S., Stone, John, Savage, Caroline O.S., Wisniacki, Nicolas, Tarzi, Ruth M.

“…Activated T cells drive a range of immune‐mediated inflammatory diseases. LAG‐3 is transiently expressed on recently activated CD4+ and CD8+ T cells. We…”
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Outcomes from massive paracetamol overdose: a retrospective observational study by Marks, Daniel J. B., Dargan, Paul I., Archer, John R. H., Davies, Charlotte L., Dines, Alison M., Wood, David M., Greene, Shaun L.

“…LINKED ARTICLE This article is commented on by Bateman DN and Dear JW. Should we treat very large paracetamol overdose differently? Br J Clin Pharmacol 2017;…”
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A qualitative study to explore the symptoms and impacts of Crohn’s disease and to develop the Crohn’s Disease Diary by Williams-Hall, Rebecca, Trennery, Claire, Sully, Kate, Wratten, Samantha, Francis, Anya, Chandler, Dale, Flynn, Jessica, Turner, Megan, Marks, Daniel J. B., Sackeyfio, Alfred, Bracher, Marguerite, Walker, Alex, Walker-Nthenda, Louise, Arbuckle, Rob, Keeley, Tom

“…Purpose To explore symptoms and disease impacts of Crohn’s disease and to develop a new patient-reported outcomes (PRO) measure according to industry best…”
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A novel Streptococcus pneumoniae human challenge model demonstrates Treg lymphocyte recruitment to the infection site by Szylar, Gabriella, Wysoczanski, Riccardo, Marshall, Helina, Marks, Daniel J. B., José, Ricardo, Ehrenstein, Michael R., Brown, Jeremy S.

“…To investigate local tissue responses to infection we have developed a human model of killed Streptococcus pneumoniae challenge by intradermal injection into…”
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Lymphocyte Activation Gene (LAG)-3 Is Associated With Mucosal Inflammation and Disease Activity in Ulcerative Colitis by Slevin, Stephanie M, Garner, Lucy C, Lahiff, Conor, Tan, Malcolm, Wang, Lai Mun, Ferry, Helen, Greenaway, Borgel, Lynch, Kate, Geremia, Alessandra, Hughes, Stephen, Leavens, Karen, Krull, David, Marks, Daniel J B, Nevin, Katherine, Page, Kevin, Srinivasan, Naren, Tarzi, Ruth, Klenerman, Paul, Travis, Simon, Arancibia-Cárcamo, Carolina V, Keshav, Satish

“…Abstract Background and Aims Lymphocyte activation gene [LAG]-3 is an immune checkpoint and its expression identifies recently activated lymphocytes that may…”
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Inflammatory Bowel Disease in CGD Reproduces the Clinicopathological Features of Crohn's Disease by MARKS, Daniel J. B, MIYAGI, Kana, RAHMAN, Farooq Z, NOVELLI, Marco, BLOOM, Stuart L, SEGAL, Anthony W

“…Patients with chronic granulomatous disease (CGD), a rare congenital disorder characterized by defective neutrophil function, frequently develop an…”
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Association of hypertension and cardiac events in patients with multiple myeloma receiving carfilzomib: practical management recommendations by Chavda, Selina J., Pocock, Rachael, Cheesman, Simon, Lee, Kyung‐Min, Dowling, Emma, Marks, Daniel J. B., Kyriakou, Charalampia, Lee, Lydia, Sive, Jonathan, Wechalekar, Ashutosh, Rabin, Neil, Yong, Kwee, Popat, Rakesh

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Defective acute inflammation in Crohn's disease: a clinical investigation by Marks, Daniel JB, Harbord, Marcus WN, MacAllister, Raymond, Rahman, Farooq Z, Young, Jodi, Al-Lazikani, Bissan, Lees, William, Novelli, Marco, Bloom, Stuart, Segal, Anthony W

“…The cause of Crohn's disease has not been mechanistically proven. We tested the hypothesis that the disease is a form of immunodeficiency caused by impaired…”
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Thoracic empyema: a 12-year study from a UK tertiary cardiothoracic referral centre by Marks, Daniel J B, Fisk, Marie D, Koo, Chieh Y, Pavlou, Menelaos, Peck, Lorraine, Lee, Simon F, Lawrence, David, Macrae, M Bruce, Wilson, A Peter R, Brown, Jeremy S, Miller, Robert F, Zumla, Alimuddin I

“…Empyema is an increasingly frequent clinical problem worldwide, and has substantial morbidity and mortality. Our objectives were to identify the clinical,…”
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Randomized Trial of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2831781 in Healthy Japanese and White Participants by Liefaard, Lia, Hajduk, Eva, den Berg, Frans, Panoilia, Eirini, Bouma, Gerben, Lisi, Edoardo, Srinivasan, Naren, Cui, Yi, Gross, Annette S., Tarzi, Ruth, Marks, Daniel J.B.

“…This study investigated ethnic differences in the safety, tolerability, pharmacokinetics, and pharmacodynamics of GSK2831781, an anti–lymphocyte activation…”
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Defective innate immunity in inflammatory bowel disease: a Crohnʼs disease exclusivity? by Marks, Daniel JB

“…PURPOSE OF REVIEWThis review summarizes the recent developments in support of the immunodeficiency model of Crohnʼs disease. RECENT FINDINGSThe demonstration…”
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Staphylococcus lugdunensis septic arthritis and epidural abscess in a patient with rheumatoid arthritis receiving anti-tumour necrosis factor therapy by Rose, Anna M, Barnett, Joseph, Morris-Jones, Stephen, Marks, Daniel J B

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Acute kidney injury and malignant hypertension caused by occlusive radiation vasculopathy by Vassilas, Christopher, Ramachandran, Navin, Laing, Chris, Marks, Daniel J B

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Leading articles in medical journals in 1966 by Stimpson, Philippa J, Marks, Daniel JB

“…The British Journal of Hospital Medicine is 50 years old. This article takes a look back at articles published during the year of its inception from the…”
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Novel translational model of resolving inflammation triggered by UV‐killed E. coli by Motwani, Madhur P, Flint, Julia D, De Maeyer, Roel PH, Fullerton, James N, Smith, Andrew M, Marks, Daniel JB, Gilroy, Derek W

“…Whilst numerous studies investigating the aetiology of inflammatory diseases have been performed in rodents, the applicability of these data to human…”
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