Search Results - "J.-P. Mach"

Recombinant Monoclonal Antibodies, from Tumor Targeting to Cancer Immunotherapy: A Critical Overview by Mach, J.-P.

“…In view of the explosion of the present clinical use of monoclonal antibodies (mAbs), not only in the treatment of cancer, but also of autoimmune diseases, I…”
Get full text

Combined cetuximab and trastuzumab are superior to gemcitabine in the treatment of human pancreatic carcinoma xenografts by Larbouret, C., Robert, B., Bascoul-Mollevi, C., Penault-Llorca, F., Ho-Pun-Cheung, A., Morisseau, S., Navarro-Teulon, I., Mach, J.-P., Pèlegrin, A., Azria, D.

“…Background: Pancreatic carcinoma remains a treatment-refractory cancer with a poor prognosis. Here, we compared anti-epidermal growth factor receptor (EGFR)…”
Get full text

Improving the chance of cure of follicular lymphoma by combining immunotherapy and radioimmunotherapy based on anti-CD20 antibodies? by Buchegger, F., Mach, J.-P., Press, O.W., Bischof Delaloye, A., Larson, S.M., Prior, J.O., Ketterer, N.

Get full text

Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc(I)-carbonyl complex by Plückthun, Andreas, Waibel, Robert, Alberto, Roger, Willuda, Jörg, Finnern, Ricarda, Schibli, Roger, Stichelberger, Albert, Egli, André, Abram, Ulrich, Mach, Jean-Pierre, Schubiger, P. August

“…We have developed a technetium labeling technology based on a new organometallic chemistry, which involves simple mixing of the novel reagent, a 99m…”
Get full text

Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis by Kos, O., Alexander, C., Brandenburg, K., Chen, Z., Heini, A., Heumann, D., Khatri, I., Mach, J.P., Rietschel, E.T., Tersikh, A., Ulmer, A.J., Waelli, T., Yu, K., Zähringer, U., Gorczynski, R.M.

“…We have shown that an altered tissue redox environment in mice lacking either murine beta Hemoglobin major (HgbβmaKO) or minor (HgbβmiKO) regulates…”
Get full text

Corrigendum to “An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression” [Int. Immunopharmacol. 50 (2017) 69–76] by Gorczynski, R.M., Alexander, C., Brandenburg, K., Chen, Z., Heini, A., Neumann, D., Mach, J.P., Rietschel, E.T., Terskikh, A., Ulmer, A.J., Yu, Kai, Zahringer, U., Khatri, I.

Get full text

An altered REDOX environment, assisted by over-expression of fetal hemoglobins, protects from inflammatory colitis and reduces inflammatory cytokine expression by Gorczynski, R.M., Alexander, C., Brandenburg, K., Chen, Z., Heini, A., Neumann, D., Mach, J.P., Rietschel, E.T., Tersikh, A., Ulmer, A.J., Yu, Kai, Zahringer, U., Khatri, I.

“…C5BL/6 female mice receiving dextran sodium sulfate in their drinking water develop an acute inflammatory colitis within 7d, with weight loss, histopathologic…”
Get full text

Corrigendum to “Regulation of fetal hemoglobin expression during hematopoietic stem cell development and its importance in bone metabolism and osteoporosis” [Int. Immunopharmacol. 57 (2018) 112–120] by Kos, O., Alexander, C., Brandenburg, K., Chen, Z., Heini, A., Heumann, D., Khatri, I., Mach, J.P., Rietschel, E.T., Terskikh, A., Ulmer, A.J., Waelli, T., Yu, K., Zähringer, U., Gorczynski, R.M.

Get full text

Antibody-indocyanin conjugates for immunophotodetection of human squamous cell carcinoma in nude mice by FOLLI, S, WESTERMANN, P, BRAICHOTTE, D, PELEGRIN, A, WAGNIERES, G, VAN DEN BERGH, H, MACH, J.-P

“…We have recently shown that immunophotodetection of human colon carcinomas in nude mice and in patients is possible by using anti-carcinoembryonic antigen…”
Get full text

Long-term complete responses after 131I-tositumomab therapy for relapsed or refractory indolent non-Hodgkin's lymphoma by BUCHEGGER, F, ANTONESCU, C, BISCHOF DELALOYE, A, HELG, C, KOVACSOVICS, T, KOSINSKI, M, MACH, J.-P, KETTERER, N

“…We present the long-term results of 18 chemotherapy relapsed indolent (N = 12) or transformed (N = 6) NHL patients of a phase II anti-CD20 (131)I-tositumomab…”
Get full text

Radioimmunotherapy of Colorectal Cancer Liver Metastases: Combination with Radiotherapy by BUCHEGGER, F., ROTH, A., ALLAL, A., DUPERTUIS, Y. M., SLOSMAN, D. O., DELALOYE, A. BISCHOF, MACH, J-P.

“…: The expected therapeutic gain of a combined radioimmunotherapy (RIT) with conventional radiotherapy (RT) would be a synergy of tumor irradiation, provided…”
Get full text

Streptabody, a high avidity molecule made by tetramerization of in vivo biotinylated, phage display-selected scFv fragments on streptavidin by Cloutier, S.M., Couty, S., Terskikh, A., Marguerat, L., Crivelli, V., Pugnières, M., Mani, J.-C., Leisinger, H.-J., Mach, J.P., Deperthes, D.

“…Phage display is a powerful method of isolating of antibody fragments from highly diverse naive human antibody repertoires. However, the affinity of the…”
Get full text

Involvement of circulating CEA in liver metastases from colorectal cancers re-examined in a new experimental model by LECONTE, A, GARAMBOIS, V, YCHOU, M, ROBERT, B, POURQUIER, D, TERSKIKH, A, MACH, J. P, PELEGRIN, A

“…Both experimental and clinical data show evidence of a correlation between elevated blood levels of carcinoembryonic antigen (CEA) and the development of liver…”
Get full text

Tumor targeting with newly designed biparatopic antibodies directed against two different epitopes of the carcinoembryonic antigen (CEA) by Robert, Bruno, Dorvillius, Mylène, Buchegger, Franz, Garambois, Véronique, Mani, Jean‐Claude, Pugnières, Martine, Mach, Jean‐Pierre, Pèlegrin, André

“…In an attempt to improve tumor targeting and tumor retention time of monoclonal antibodies (MAbs), we prepared biparatopic antibodies (BpAbs) having the…”
Get full text

Antibody‐conjugated MHC class I tetramers can target tumor cells for specific lysis by T lymphocytes by Robert, Bruno, Guillaume, Philippe, Luescher, Immanuel, Romero, Pedro, Mach, Jean‐Pierre

“…To demonstrate that antibody‐guided targeting of antigenic MHC class I‐peptide tetramer on tumor cells can render them susceptible to lysis by relevant…”
Get full text

Human scFv antibody fragments specific for the epithelial tumour marker MUC-1, selected by phage display on living cells by WONG, Cindy, WAIBEL, Robert, SHEETS, Michael, MACH, Jean-Pierre, FINNERN, Ricarda

“…New anti-cancer agents are being developed that specifically recognise tumour cells. Recognition is dependent upon the enhanced expression of antigenic…”
Get full text

Penetration and binding of radiolabeled anti-carcinoembryonic antigen monoclonal antibodies and their antigen binding fragments in human colon multicellular tumor spheroids by SUTHERLAND, R, BUCHEGGER, F, SCHREYER, M, VACCA, A, MACH, J.-P

“…The binding and penetration of two 125I-labeled anti-carcinoembryonic antigen (CEA) monoclonal antibodies (MAb) and their F(ab')2 and Fab fragments were…”
Get full text

Iodine-131-Labeled MAb F(ab')2 Fragments Are More Efficient and Less Toxic Than Intact Anti-CEA Antibodies in Radioimmunotherapy of Large Human Colon Carcinoma Grafted in Nude Mice by Buchegger, Franz, Pelegrin, Andre, Delaloye, Bernard, Bischof-Delaloye, Angelika, Mach, Jean-Pierre

“…During one week, beginning 18 days after transplantation, nude mice bearing human colon carcinoma ranging from 115 to 943 mm3 (mean 335 mm3) were treated by…”
Get full text

Long circulating half‐life and high tumor selectivity of the photosensitizer meta‐tetrahydroxyphenylchlorin conjugated to polyethylene glycol in nude mice grafted with a human colon carcinoma by Westermann, Patrick, Glanzmann, Thomas, Andrejevic, Snezana, Braichotte, Daniel R., Forrer, Martin, Wagnieres, Georges A., Monnier, Philippe, van den Bergh, Hubert, Mach, Jean‐Pierre, Folli, Silvio

“…In a model of nude mice bearing a human colon carcinoma xenograft, the biodistribution and tumor localization of meta‐tetrahydroxyphenylchlorin (m‐THPC)…”
Get full text

Characterization of an interaction between fetal hemoglobin and lipid A of LPS resulting in augmented induction of cytokine production in vivo and in vitro by Gorczynski, R.M., Alexander, C., Bessler, W., Fournier, K., Hoffmann, P., Mach, J.P., Ramakrishna, V., Rietschel, E.T., Song, L., Waelli, Th, Westphal, O., Zahringer, U., Manuel, J.

“…A previously described extract of sheep fetal liver was reported to reverse many of the cytokine changes associated with aging in mice, including an augmented…”
Get full text