Search Results - "J.-J. Fournié"

NALP1 Influences Susceptibility to Human Congenital Toxoplasmosis, Proinflammatory Cytokine Response, and Fate of Toxoplasma gondii-Infected Monocytic Cells by Witola, William H, Mui, Ernest, Hargrave, Aubrey, Liu, Susan, Hypolite, Magali, Montpetit, Alexandre, Cavailles, Pierre, Bisanz, Cordelia, Cesbron-Delauw, Marie-France, Fournié, Gilbert J, McLeod, Rima

“…NALP1 is a member of the NOD-like receptor (NLR) family of proteins that form inflammasomes. Upon cellular infection or stress, inflammasomes are activated,…”
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Immune recovery after fludarabine-cyclophosphamide-rituximab treatment in B-chronic lymphocytic leukemia: implication for maintenance immunotherapy by Ysebaert, L, Gross, E, Kühlein, E, Blanc, A, Corre, J, Fournié, J J, Laurent, G, Quillet-Mary, A

“…Thirty B-cell chronic lymphocytic leukemia patients were treated with fludarabine–cyclophosphamide–rituximab (FCR) and immune cell counts (natural killer (NK)…”
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A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage by Cavailles, Pierre, Flori, Pierre, Papapietro, Olivier, Bisanz, Cordelia, Lagrange, Dominique, Pilloux, Ludovic, Massera, Céline, Cristinelli, Sara, Jublot, Delphine, Bastien, Olivier, Loeuillet, Corinne, Aldebert, Delphine, Touquet, Bastien, Fournié, Gilbert J, Cesbron-Delauw, Marie France

“…Natural immunity or resistance to pathogens most often relies on the genetic make-up of the host. In a LEW rat model of refractoriness to toxoplasmosis, we…”
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Involvement of the Syk-mTOR pathway in follicular lymphoma cell invasion and angiogenesis by Fruchon, S, Kheirallah, S, Al Saati, T, Ysebaert, L, Laurent, C, Leseux, L, Fournié, J J, Laurent, G, Bezombes, C

“…Follicular lymphoma (FL) is the second-most common non-Hodgkin's lymphoma. The disease affects the lymph nodes, and 50% of patients present with bone marrow…”
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A Natural Variant of the T Cell Receptor-Signaling Molecule Vav1 Reduces Both Effector T Cell Functions and Susceptibility to Neuroinflammation by Kassem, Sahar, Gaud, Guillaume, Bernard, Isabelle, Benamar, Mehdi, Dejean, Anne S, Liblau, Roland, Fournié, Gilbert J, Colacios, Céline, Malissen, Bernard, Saoudi, Abdelhadi

“…The guanine nucleotide exchange factor Vav1 is essential for transducing T cell antigen receptor signals and therefore plays an important role in T cell…”
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B-chronic lymphocytic leukemia chemoresistance involves innate and acquired leukemic side population cells by Gross, E, L’Faqihi-Olive, F-E, Ysebaert, L, Brassac, M, Struski, S, Kheirallah, S, Fournié, J-J, Laurent, G, Quillet-Mary, A

“…B-cell chronic lymphocytic leukemia (B-CLL) therapy remains unsatisfactory due to repeated resurgences of the chemoresistant disease. In this study, we…”
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Nurse-like cells mediate ibrutinib resistance in chronic lymphocytic leukemia patients by Boissard, F, Fournié, J-J, Quillet-Mary, A, Ysebaert, L, Poupot, M

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An Epistatic Interaction between Themis1 and Vav1 Modulates Regulatory T Cell Function and Inflammatory Bowel Disease Development by Pedros, Christophe, Gaud, Guillaume, Bernard, Isabelle, Kassem, Sahar, Chabod, Marianne, Lagrange, Dominique, Andréoletti, Olivier, Dejean, Anne S, Lesourne, Renaud, Fournié, Gilbert J, Saoudi, Abdelhadi

“…The development of inflammatory diseases depends on complex interactions between several genes and various environmental factors. Discovering new genetic risk…”
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VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis by Guerreiro-Cacais, A O, Norin, U, Gyllenberg, A, Berglund, R, Beyeen, A D, Petit-Teixeira, E, Cornélis, F, Saoudi, A, Fournié, G J, Holmdahl, R, Alfredsson, L, Klareskog, L, Jagodic, M, Olsson, T, Kockum, I, Padyukov, L

“…Rheumatoid arthritis (RA) patients can be stratified into two subgroups defined by the presence or absence of antibodies against citrullinated circular…”
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Murine Natural Killer Cells Contribute to the Granulomatous Reaction Caused by Mycobacterial Cell Walls by Apostolou, I., Takahama, Y., Belmant, C., Kawano, T., Huerre, M., Marchal, G., Cui, J., Taniguchi, M., Nakauchi, H., J.-J. Fournié, Kourilsky, P., Gachelin, G.

“…Mice injected with deproteinized cell walls prepared from the strain H37rv of Mycobacterium tuberculosis develop a granuloma-like lesion in which NKT cells are…”
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Microwave biosensor dedicated to the dielectric spectroscopy of a single alive biological cell in its culture medium by Chen, T., Artis, F., Dubuc, D., Fournie, J.-J, Poupot, M., Grenier, K.

“…This paper presents a biosensor dedicated to the dielectric spectroscopy of a single and living biological cell in its liquid culture medium in the micro and…”
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A spontaneous mutation of the rat Themis gene leads to impaired function of regulatory T cells linked to inflammatory bowel disease by Chabod, Marianne, Pedros, Christophe, Lamouroux, Lucille, Colacios, Céline, Bernard, Isabelle, Lagrange, Dominique, Balz-Hara, Daniela, Mosnier, Jean-Francois, Laboisse, Christian, Vergnolle, Nathalie, Andreoletti, Olivier, Roth, Marie-Paule, Liblau, Roland, Fournié, Gilbert J, Saoudi, Abdelhadi, Dejean, Anne S

“…Spontaneous or chemically induced germline mutations, which lead to Mendelian phenotypes, are powerful tools to discover new genes and their functions. Here,…”
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Idelalisib improves CD37 antibody BI 836826 cytotoxicity against chemo-resistant /relapse-initiating CLL cells: a rationale for combination treatment by Betrian, S, Ysebaert, L, Heider, K H, Delord, J P, Fournié, J J, Quillet-Mary, A

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TAyloring LYmphoma therapy with Immune Escape Signatures from 3D avatars of B‐cell NHL by Gava, F., Faria, C., Gravelle, P., Garcia‐Valero, J., Quelen, C., Serrat, N., Gower, N., Morschhauser, F., Fournié, J., Bouquet, F., Fonseca, C., Herter, S., Codarri, L., McCord, R., Chiang, E., Laurent, C., Perez‐Galan, P., Ysebaert, L., Bezombes, C.

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The serine‐threonine kinase p90RSK is a new target of enzastaurin in follicular lymphoma cells by Kheirallah, S, Fruchon, S, Ysebaert, L, Blanc, A, Capilla, F, Marrot, A, AlSaati, T, Frenois, F X, Benhadji, K A, Fournié, J J, Laurent, G, Bezombes, C

“…Background and Purpose Follicular lymphoma is the second most common non‐Hodgkin's lymphoma and, despite the introduction of rituximab for its treatment, this…”
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Anti-tumor activity of obinutuzumab and rituximab in a follicular lymphoma 3D model by Decaup, E, Jean, C, Laurent, C, Gravelle, P, Fruchon, S, Capilla, F, Marrot, A, Al Saati, T, Frenois, F-X, Laurent, G, Klein, C, Varoqueaux, N, Savina, A, Fournié, J-J, Bezombes, C

“…Follicular lymphomas (FLs) account for 35–40% of all adult lymphomas. Treatment typically involves chemotherapy combined with the anti-CD20 monoclonal antibody…”
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Nurse-like cells impact on disease progression in chronic lymphocytic leukemia by Boissard, F, Laurent, C, Ramsay, A G, Quillet-Mary, A, Fournié, J-J, Poupot, M, Ysebaert, L

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The p.Arg63Trp polymorphism controls Vav1 functions and Foxp3 regulatory T cell development by Colacios, Céline, Casemayou, Audrey, Dejean, Anne S, Gaits-Iacovoni, Frédérique, Pedros, Christophe, Bernard, Isabelle, Lagrange, Dominique, Deckert, Marcel, Lamouroux, Lucille, Jagodic, Maja, Olsson, Tomas, Liblau, Roland S, Fournié, Gilbert J, Saoudi, Abdelhadi

“…CD4(+) regulatory T cells (T(reg) cells) expressing the transcription factor Foxp3 play a pivotal role in maintaining peripheral tolerance by inhibiting the…”
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The Rat Toxo1 Locus Directs Toxoplasmosis Outcome and Controls Parasite Proliferation and Spreading by Macrophage-Dependent Mechanisms by Cavaillès, Pierre, Sergent, Véronique, Bisanz, Cordelia, Papapietro, Olivier, Colacios, Céline, Mas, Magali, Subra, Jean-François, Lagrange, Dominique, Calise, Maryline, Appolinaire, Sylvie, Faraut, Thomas, Druet, Philippe, Saoudi, Abdelhadi, Bessieres, Marie-Hélène, Pipy, Bernard, Cesbron-Delauw, Marie-France, Fournié, Gilbert J.

“…Toxoplasmosis is a healthcare problem in pregnant women and immunocompromised patients. Like humans, rats usually develop a subclinical chronic infection. LEW…”
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Single-Cell Signature Explorer for comprehensive visualization of single cell signatures across scRNA-seq datasets by Pont, Frédéric, Tosolini, Marie, Fournié, Jean J

“…Abstract The momentum of scRNA-seq datasets prompts for simple and powerful tools exploring their meaningful signatures. Here we present…”
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