Search Results - "J.-C. Dodart"

Memory-Enhancing Effects of Secreted Forms of the β -amyloid Precursor Protein in Normal and Amnestic Mice by Meziane, H., J.-C. Dodart, Mathis, C., Little, S., Clemens, J., Paul, S. M., Ungerer, A.

“…When administered intracerebroventricularly to mice performing various learning tasks involving either short-term or long-term memory, secreted forms of the β…”
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Peri‐arterial pathways for clearance of α‐Synuclein and tau from the brain: Implications for the pathogenesis of dementias and for immunotherapy by Nimmo, Jacqui, Johnston, David A., Dodart, J. C., MacGregor‐Sharp, Matthew T., Weller, Roy O., Nicoll, James A. R., Verma, Ajay, Carare, Roxana O.

“…Introduction Accumulation of amyloid beta (Aβ), α‐synuclein (αSyn), and tau in dementias indicates their age‐related failure of elimination from the brain. Aβ…”
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Does my mouse have Alzheimer's disease? by Dodart, J.‐C., Mathis, C., Bales, K. R., Paul, S. M.

“…Small animal models that manifest many of the characteristic neuropathological and behavioral features of Alzheimer's disease (AD) have been developed and have…”
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Isoform‐specific effects of apolipoprotein E on cognitive performance in targeted‐replacement mice overexpressing human APP by Kornecook, T. J., McKinney, A. P., Ferguson, M. T., Dodart, J.‐C.

“…The ε4 allele of apolipoprotein E (apoE4) is the predominant genetic risk factor for late‐onset Alzheimer's disease (AD) and is also implicated in cognitive…”
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Scopolamine-induced deficits in a two-trial object recognition task in mice by Dodart, J C, Mathis, C, Ungerer, A

“…THE purpose of the present study was to design an object recognition task in mice and characterize the effects of scopolamine in this paradigm. This task…”
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Holeboard discrimination learning in mice by Kuc, K. A., Gregersen, B. M., Gannon, K. S., Dodart, J.‐C.

“…We have adapted to mice a holeboard‐learning task, which allows simultaneous assessment of spatial working and reference‐memory performance. The holeboard…”
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Behavioral Disturbances in Transgenic Mice Overexpressing the V717F β-Amyloid Precursor Protein by Dodart, Jean-Cosme, Meziane, Hamid, Mathis, Chantal, Bales, Kelly R, Paul, Steven M, Ungerer, Arielle

“…PDAPP transgenic mice have been shown to develop age dependently much of the cerebral histopathology associated with Alzheimer's disease. PDAPP mice (3-10…”
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Early regional cerebral glucose hypometabolism in transgenic mice overexpressing the V717F β-amyloid precursor protein by Dodart, Jean-Cosme, Mathis, Chantal, Bales, Kelly R, Paul, Steven M, Ungerer, Arielle

“…In the present study, we examined whether the relative levels of regional brain [ 14C]2-deoxyglucose (2-DG) uptake are altered in a transgenic mouse model of…”
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Peripheral Anti-Aβ Antibody Alters CNS and Plasma Aβ Clearance and Decreases Brain Aβ Burden in a Mouse Model of Alzheimer's Disease by DeMattos, R B, Bales, K R, Cummins, D J, Dodart, J C, Paul, S M, Holtzman, D M

“…Active immunization with the amyloid β (Aβ) peptide has been shown to decrease brain Aβ deposition in transgenic mouse models of Alzheimer's disease and…”
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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model by Paul, Steven M, Dodart, Jean-Cosme, Bales, Kelly R, Gannon, Kimberley S, Greene, Stephen J, DeMattos, Ronald B, Mathis, Chantal, DeLong, Cynthia A, Wu, Su, Wu, Xin, Holtzman, David M

“…We have previously shown that chronic treatment with the monoclonal antibody m266, which is specific for amyloid beta -peptide (A beta ), increases plasma…”
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Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene by Dodart, J C, Mathis, C, Bales, K R, Paul, S M, Ungerer, A

“…Both the beta-amyloid precursor protein (APP) and the apoliprotein E (apoE) genes are involved in the pathogenesis of Alzheimer's disease (AD). We previously…”
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Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior by Grootendorst, Jeannette, Bour, Alexandra, Vogel, Elise, Kelche, Christian, Sullivan, Patrick M., Dodart, Jean-Cosme, Bales, Kelly, Mathis, Chantal

“…Apolipoprotein E4 (apoE4), one of the three most common human apoE (h-apoE) isoforms, is a major genetic risk factor for Alzheimer's disease and for cognitive…”
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P2.003 Selective spatial learning impairments and attention deflcits precede a frank motor phenotype in a mouse model of Parkinson's disease by Browne, S.E, Dillon, G, Ferguson, M, Reynolds, I.J, Dodart, J.-C

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Apolipoprotein E, Amyloid, and Alzheimer Disease by Bales, K R, Dodart, J C, DeMattos, R B, Holtzman, D M, Paul, S M

“…The alleles for apolipoprotein E (apoE) represent important genetic risk factors for the most common late-onset forms of Alzheimer disease (AD), with the ε 4…”
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Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice by Dodart, J C, Mathis, C, Saura, J, Bales, K R, Paul, S M, Ungerer, A

“…Histological analyses were performed on the brains of APP(V717F) transgenic (Tg)mice previously studied in a battery of behavioral tests. We describe here the…”
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Immunotherapy for Alzheimer's disease: will vaccination work? by Dodart, Jean-Cosme, Bales, Kelly R., Paul, Steven M.

“…Active or passive immunization against the β-amyloid peptide (Aβ) has been proposed as a method for preventing and/or treating Alzheimer's disease (AD). In…”
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The beta-amyloid precursor protein and its derivatives: from biology to learning and memory processes by Dodart, J C, Mathis, C, Ungerer, A

“…Intensive investigation towards the understanding of the biology and physiological functions of the beta-amyloid precursor protein (APP) have been supported…”
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Behavioral deficits in APPV717F transgenic mice decient for the apolipoprotein E gene by Dodart, J.-C, Mathis, C, Bales, K R, Paul, SM, Ungerer, A

“…Both the β-amyloid precursor protein (APP) and the apoliprotein E (apoE) genes are involved in the pathogenesis of Alzheimerʼs disease (AD). We previously…”
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Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks by Bour, Alexandra, Grootendorst, Jeannette, Vogel, Elise, Kelche, Christian, Dodart, Jean-Cosme, Bales, Kelly, Moreau, Pierre-Henri, Sullivan, Patrick M., Mathis, Chantal

“…Apolipoprotein (apo) E4, one of three human apoE (h-apoE) isoforms, has been identified as a major genetic risk factor for Alzheimer's disease and for…”
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Excitotoxic lesions restricted to the dorsal CA1 field of the hippocampus impair spatial memory and extinction learning in C57BL/6 mice by Dillon, Gregory M., Qu, Xianlu, Marcus, Jacob N., Dodart, Jean-Cosme

“…Recent studies in patients with hippocampal lesions have indicated that the degree of memory impairment is proportional to the extent of damage within the…”
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