Search Results - "J.-C. Bourdon"

p53 and its isoforms in cancer by BOURDON, J.-C

“…p53, p63 and p73 are members of the p53 gene family involved in development, differentiation and response to cellular stress. p53 gene is a transcription…”
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p53 p63 p73 isoforms: an orchestra of isoforms to harmonise cell differentiation and response to stress by Murray-Zmijewski, F, Lane, D P, Bourdon, J-C

“…p63, p73 and p53 compose a family of transcription factors involved in cell response to stress and development. p53 is the most frequently mutated gene in…”
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Biological functions of p53 isoforms through evolution: lessons from animal and cellular models by Marcel, V, Dichtel-Danjoy, M-L, Sagne, C, Hafsi, H, Ma, D, Ortiz-Cuaran, S, Olivier, M, Hall, J, Mollereau, B, Hainaut, P, Bourdon, J-C

“…The TP53 tumour-suppressor gene is expressed as several protein isoforms generated by different mechanisms, including use of alternative promoters, splicing…”
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p53 is activated in response to disruption of the pre-mRNA splicing machinery by Allende-Vega, N, Dayal, S, Agarwala, U, Sparks, A, Bourdon, J-C, Saville, M K

“…In this study, we show that interfering with the splicing machinery results in activation of the tumour-suppressor p53. The spliceosome was targeted by small…”
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Cdc25B is negatively regulated by p53 through Sp1 and NF-Y transcription factors by Dalvai, M, Mondesert, O, Bourdon, J-C, Ducommun, B, Dozier, C

“…Cdc25B phosphatases function as key players in G2/M cell cycle progression by activating the CDK1–cyclinB1 complexes. They also have an essential role in…”
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Correlation analysis of p53 protein isoforms with NPM1/FLT3 mutations and therapy response in acute myeloid leukemia by Ånensen, N, Hjelle, S M, Van Belle, W, Haaland, I, Silden, E, Bourdon, J-C, Hovland, R, Taskén, K, Knappskog, S, Lønning, P E, Bruserud, Ø, Gjertsen, B T

“…The wild-type tumor-suppressor gene TP53 encodes several isoforms of the p53 protein. However, while the role of p53 in controlling normal cell cycle…”
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The heparan sulfate sulfotransferase 3-OST3A (HS3ST3A) is a novel tumor regulator and a prognostic marker in breast cancer by Mao, X, Gauche, C, Coughtrie, M W H, Bui, C, Gulberti, S, Merhi-Soussi, F, Ramalanjaona, N, Bertin-Jung, I, Diot, A, Dumas, D, De Freitas Caires, N, Thompson, A M, Bourdon, J-C, Ouzzine, M, Fournel-Gigleux, S

“…Heparan sulfate (HS) proteoglycan chains are key components of the breast tumor microenvironment that critically influence the behavior of cancer cells. It is…”
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Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity by Marcel, V, Petit, I, Murray-Zmijewski, F, Goullet de Rugy, T, Fernandes, K, Meuray, V, Diot, A, Lane, D P, Aberdam, D, Bourdon, J-C

“…In response to stress, p53 binds and transactivates the internal TP53 promoter, thus regulating the expression of its own isoform, Δ133p53 α . Here, we report…”
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Drosophila p53 isoforms differentially regulate apoptosis and apoptosis-induced proliferation by Dichtel-Danjoy, M-L, Ma, D, Dourlen, P, Chatelain, G, Napoletano, F, Robin, M, Corbet, M, Levet, C, Hafsi, H, Hainaut, P, Ryoo, H D, Bourdon, J-C, Mollereau, B

“…Irradiated or injured cells enter apoptosis, and in turn, promote proliferation of surrounding unaffected cells. In Drosophila , apoptotic cells have an active…”
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Integrative mRNA profiling comparing cultured primary cells with clinical samples reveals PLK1 and C20orf20 as therapeutic targets in cutaneous squamous cell carcinoma by Watt, S A, Pourreyron, C, Purdie, K, Hogan, C, Cole, C L, Foster, N, Pratt, N, Bourdon, J-C, Appleyard, V, Murray, K, Thompson, A M, Mao, X, Mein, C, Bruckner-Tuderman, L, Evans, A, McGrath, J A, Proby, C M, Foerster, J, Leigh, I M, South, A P

“…Identifying therapeutic targets for cancer treatment relies on consistent changes within particular types or sub-types of malignancy. The ability to define…”
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Scotin, a Novel p53-Inducible Proapoptotic Protein Located in the ER and the Nuclear Membrane by J.-C. Bourdon, Renzing, J., Robertson, P. L., Fernandes, K. N., Lane, D. P.

“…p53 is a transcription factor that induces growth arrest or apoptosis in response to cellular stress. To identify new p53-inducible proapoptotic genes, we…”
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p53 mutation, deprivation and poor prognosis in primary breast cancer by Baker, L, Quinlan, P R, Patten, N, Ashfield, A, Birse-Stewart-Bell, L-J, McCowan, C, Bourdon, J-C, Purdie, C A, Jordan, L B, Dewar, J A, Wu, L, Thompson, A M

“…Background: The deprivation gap for breast cancer survival remains unexplained by stage at presentation, treatment, or co-morbidities. We hypothesised that p53…”
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The RNA helicase p68 modulates expression and function of the Δ133 isoform(s) of p53, and is inversely associated with Δ133p53 expression in breast cancer by Moore, H C, Jordan, L B, Bray, S E, Baker, L, Quinlan, P R, Purdie, C A, Thompson, A M, Bourdon, J-C, Fuller-Pace, F V

“…The RNA helicase p68 is a potent co-activator of p53-dependent transcription in response to DNA damage. Previous independent studies have indicated that p68…”
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p53 isoforms change p53 paradigm by Bourdon, JC

“…Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called…”
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First International p53 Isoforms Meeting: 'p53 isoforms through evolution: from identification to biological function' by Marcel, V, Olivier, M, Mollereau, B, Hainaut, P, Bourdon, J-C

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Modulation of p53β and p53γ expression by regulating the alternative splicing of TP53 gene modifies cellular response by Marcel, V, Fernandes, K, Terrier, O, Lane, D P, Bourdon, J-C

“…In addition to the tumor suppressor p53 protein, also termed p53 α , the TP53 gene produces p53 β and p53 γ through alternative splicing of exons 9 β and 9 γ…”
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p53: 25 years of research and more questions to answer by Bourdon, J C, Laurenzi, V De, Melino, G, Lane, D

“…Cell Death and Differentiation (2002) 10, 397-399. doi:10.1038/sj.cdd.4401243…”
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The isoforms of the p53 protein by Khoury, Marie P, Bourdon, Jean-Christophe

“…p53 is a transcription factor with a key role in the maintenance of genetic stability and therefore preventing cancer formation. It belongs to a family of…”
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Further characterisation of the p53 responsive element - identification of new candidate genes for trans-activation by p53 by BOURDON, J.-C, DEGUIN-CHAMBON, V, LELONG, J.-C, DESSEN, P, MAY, P, DEBUIRE, B, MAY, E

“…The p53 protein is known to trans-activate a number of genes by specific binding to a consensus sequence containing two decamers of the type:…”
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p53 Isoforms: An Intracellular Microprocessor? by Khoury, Marie P, Bourdon, Jean-Christophe

“…Normal function of the p53 pathway is ubiquitously lost in cancers either through mutation or inactivating interaction with viral or cellular proteins…”
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