Search Results - "J. van der Laan"

LGR5 marks targetable tumor-initiating cells in mouse liver cancer by Cao, Wanlu, Li, Meng, Liu, Jiaye, Zhang, Shaoshi, Noordam, Lisanne, Verstegen, Monique M. A., Wang, Ling, Ma, Buyun, Li, Shan, Wang, Wenshi, Bolkestein, Michiel, Doukas, Michael, Chen, Kan, Ma, Zhongren, Bruno, Marco, Sprengers, Dave, Kwekkeboom, Jaap, van der Laan, Luc J. W., Smits, Ron, Peppelenbosch, Maikel P., Pan, Qiuwei

“…Cancer stem cells (CSCs) or tumor-initiating cells (TICs) are thought to be the main drivers for disease progression and treatment resistance across various…”
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Defining and estimating effects in cluster randomized trials: A methods comparison by Benitez, Alejandra, Petersen, Maya L., der Laan, Mark J., Santos, Nicole, Butrick, Elizabeth, Walker, Dilys, Ghosh, Rakesh, Otieno, Phelgona, Waiswa, Peter, Balzer, Laura B.

“…Across research disciplines, cluster randomized trials (CRTs) are commonly implemented to evaluate interventions delivered to groups of participants, such as…”
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Parametric-Rate Inference for One-Sided Differentiable Parameters by Luedtke, Alexander R., Laan, Mark J. van der

“…Suppose one has a collection of parameters indexed by a (possibly infinite dimensional) set. Given data generated from some distribution, the objective is to…”
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Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels by Arnold, Benjamin F, van der Laan, Mark J, Hubbard, Alan E, Steel, Cathy, Kubofcik, Joseph, Hamlin, Katy L, Moss, Delynn M, Nutman, Thomas B, Priest, Jeffrey W, Lammie, Patrick J

“…Serological antibody levels are a sensitive marker of pathogen exposure, and advances in multiplex assays have created enormous potential for large-scale,…”
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Nutritional status and out-of-hospital mortality in vascular surgery patients by von Meijenfeldt, G. C. I, Mogensen, K. M, van der Laan, M. J, Zeebregts, C. J, Christopher, K. B

“…Background Malnutrition is often present in vascular surgery patient during hospital admission. The present evidence of the consequence malnutrition has on…”
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Tissue-specific mutation accumulation in human adult stem cells during life by Blokzijl, Francis, de Ligt, Joep, Jager, Myrthe, Sasselli, Valentina, Roerink, Sophie, Sasaki, Nobuo, Huch, Meritxell, Boymans, Sander, Kuijk, Ewart, Prins, Pjotr, Nijman, Isaac J., Martincorena, Inigo, Mokry, Michal, Wiegerinck, Caroline L., Middendorp, Sabine, Sato, Toshiro, Schwank, Gerald, Nieuwenhuis, Edward E. S., Verstegen, Monique M. A., van der Laan, Luc J. W., de Jonge, Jeroen, IJzermans, Jan N. M., Vries, Robert G., van de Wetering, Marc, Stratton, Michael R., Clevers, Hans, Cuppen, Edwin, van Boxtel, Ruben

“…Stem cells of the liver, colon and small intestine gradually accumulate mutations throughout life at a similar rate even though cancer incidence varies greatly…”
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Optical simulation of monolithic scintillator detectors using GATE/GEANT4 by van der Laan, D J Jan, Schaart, Dennis R, Maas, Marnix C, Beekman, Freek J, Bruyndonckx, Peter, van Eijk, Carel W E

“…Much research is being conducted on position-sensitive scintillation detectors for medical imaging, particularly for emission tomography. Monte Carlo…”
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Pillbox Organizers are Associated with Improved Adherence to HIV Antiretroviral Therapy and Viral Suppression: a Marginal Structural Model Analysis by Petersen, Maya L., Wang, Yue, van der Laan, Mark J., Guzman, David, Riley, Elise, Bangsberg, David R.

“…Background. Pillbox organizers are inexpensive and easily used; however, their effect on adherence to antiretroviral medications is unknown. Methods. Data were…”
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Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment by ROSENBLUM, M., VAN DER LAAN, M. J.

“…It is a challenge to evaluate experimental treatments where it is suspected that the treatment effect may only be strong for certain subpopulations, such as…”
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Prime editing for functional repair in patient-derived disease models by Schene, Imre F., Joore, Indi P., Oka, Rurika, Mokry, Michal, van Vugt, Anke H. M., van Boxtel, Ruben, van der Doef, Hubert P. J., van der Laan, Luc J. W., Verstegen, Monique M. A., van Hasselt, Peter M., Nieuwenhuis, Edward E. S., Fuchs, Sabine A.

“…Prime editing is a recent genome editing technology using fusion proteins of Cas9-nickase and reverse transcriptase, that holds promise to correct the vast…”
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The Response of HeLa Cells to Fluorescent NanoDiamond Uptake by Hemelaar, Simon R, Saspaanithy, Babujhi, L'Hommelet, Severin R M, Perona Martinez, Felipe P, van der Laan, Kiran J, Schirhagl, Romana

“…Fluorescent nanodiamonds are promising probes for nanoscale magnetic resonance measurements. Their physical properties predict them to have particularly useful…”
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Population intervention models in causal inference by Hubbard, Alan E., van der Laan, Mark J.

“…We propose a new causal parameter, which is a natural extension of existing approaches to causal inference such as marginal structural models. Modelling…”
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Personalized online ensemble machine learning with applications for dynamic data streams by Malenica, Ivana, Phillips, Rachael V., Chambaz, Antoine, Hubbard, Alan E., Pirracchio, Romain, Laan, Mark J.

“…In this work we introduce the personalized online super learner (POSL), an online personalizable ensemble machine learning algorithm for streaming data. POSL…”
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Label-Free Imaging Analysis of Patient-Derived Cholangiocarcinoma Organoids after Sorafenib Treatment by Koch, Michael, Nickel, Sandra, Lieshout, Ruby, Lissek, Susanna M, Leskova, Martina, van der Laan, Luc J W, Verstegen, Monique M A, Christ, Bruno, Pampaloni, Francesco

“…Monitoring tumor growth dynamics is crucial for understanding cancer. To establish an in vitro method for the continuous assessment of patient-specific tumor…”
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Marginal Mean Models for Dynamic Regimes by Murphy, S A, van der Laan, M J, Robins, J M

“…A dynamic treatment regime is a list of rules for how the level of treatment will be tailored through time to an individual's changing severity. In general,…”
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Systematic Review on the Mid-Term Outcomes of Elective Endovascular Aneurysm Sealing in Comparison to Endovascular Aneurysm Repair by Zoethout, Aleksandra C, Hochstenbach, Iris, van der Laan, Maarten J, de Vries, Jean-Paul P.M, Reijnen, Michel M.P.J., Zeebregts, Clark J

“…Introduction The Nellix endovascular aneurysm sealing (EVAS) system has been a topic of discussion. Early results were promising but did not deliver on the…”
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Scalable Production of Size-Controlled Cholangiocyte and Cholangiocarcinoma Organoids within Liver Extracellular Matrix-Containing Microcapsules by van Tienderen, Gilles S, Willemse, Jorke, van Loo, Bas, van Hengel, Eline V A, de Jonge, Jeroen, van der Laan, Luc J W, Leijten, Jeroen, Verstegen, Monique M A

“…Advances in biomaterials, particularly in combination with encapsulation strategies, have provided excellent opportunities to increase reproducibility and…”
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Generally Applicable Transformation Protocols for Fluorescent Nanodiamond Internalization into Cells by Hemelaar, Simon R., van der Laan, Kiran J., Hinterding, Sophie R., Koot, Manon V., Ellermann, Else, Perona-Martinez, Felipe P., Roig, David, Hommelet, Severin, Novarina, Daniele, Takahashi, Hiroki, Chang, Michael, Schirhagl, Romana

“…Fluorescent nanodiamonds (FNDs) are promising nanoprobes, owing to their stable and magnetosensitive fluorescence. Therefore they can probe properties as…”
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Use of statins is associated with an increased risk of rheumatoid arthritis by de Jong, H J I, Klungel, O H, van Dijk, L, Vandebriel, R J, Leufkens, H G M, van der Laan, J W, Cohen Tervaert, J W, van Loveren, H

“…Statins offer significant cardiovascular benefits. Their use, however, influences immune regulation, which may potentially facilitate autoimmunity, eventually…”
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Red cell distribution width at hospital discharge and out-of hospital outcomes in critically ill non-cardiac vascular surgery patients by von Meijenfeldt, Gerdine C I, van der Laan, Maarten J, Zeebregts, Clark J A M, Christopher, Kenneth B

“…Red cell distribution width (RDW) is associated with mortality and bloodstream infection risk in the critically ill. In vascular surgery patients surviving…”
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