Search Results - "J. Yu"

Engineered T Cell Therapy for Cancer in the Clinic by Zhao, Lijun, Cao, Yu J

“…T cells play a key role in cell-mediated immunity, and strategies to genetically modify T cells, including chimeric antigen receptor (CAR) T cell therapy and T…”
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Cryo-EM structure of an activated GPCR–G protein complex in lipid nanodiscs by Zhang, Meng, Gui, Miao, Wang, Zi-Fu, Gorgulla, Christoph, Yu, James J., Wu, Hao, Sun, Zhen-yu J., Klenk, Christoph, Merklinger, Lisa, Morstein, Lena, Hagn, Franz, Plückthun, Andreas, Brown, Alan, Nasr, Mahmoud L., Wagner, Gerhard

“…G-protein-coupled receptors (GPCRs) are the largest superfamily of transmembrane proteins and the targets of over 30% of currently marketed pharmaceuticals…”
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PUMA, a potent killer with or without p53 by Yu, J, Zhang, L

“…PUMA ( p 53 u pregulated m odulator of a poptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family member and a critical mediator of p53-dependent and…”
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Adoptive Cell Therapy Targeting Neoantigens: A Frontier for Cancer Research by Wang, Zhidong, Cao, Yu J

“…Adoptive cell therapy (ACT) is a kind of immunotherapy in which T cells are genetically modified to express a chimeric antigen receptor (CAR) or T cell…”
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Early antiviral treatment contributes to alleviate the severity and improve the prognosis of patients with novel coronavirus disease (COVID‐19) by Wu, J., Li, W., Shi, X., Chen, Z., Jiang, B., Liu, J., Wang, D., Liu, C., Meng, Y., Cui, L., Yu, J., Cao, H., Li, L.

“…Background At present, the severity of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has been a focal point. Methods To…”
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Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches by Wong, C C, Qian, Y, Yu, J

“…Epigenetic and metabolic alterations in cancer cells are highly intertwined. Oncogene-driven metabolic rewiring modifies the epigenetic landscape via…”
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Impact of postoperative infective complications on long‐term survival after liver resection for hepatocellular carcinoma by Yang, T., Liu, K., Liu, C.‐F., Zhong, Q., Zhang, J., Yu, J.‐J., Liang, L., Li, C., Wang, M.‐D., Li, Z.‐L., Wu, H., Xing, H., Han, J., Lau, W. Y., Zeng, Y.‐Y., Zhou, Y.‐H., Gu, W.‐M., Wang, H., Chen, T.‐H., Zhang, Y.‐M., Zhang, W.‐G., Pawlik, T. M., Wu, M.‐C., Shen, F.

“…Background Postoperative complications have a great impact on the postoperative course and oncological outcomes following major cancer surgery. Among them,…”
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Letter: Baveno‐VI criteria to exclude large varices in patients with hepatocellular carcinoma—What have we learned? by Wong, Yu J.

“…LINKED CONTENT This article is linked to Allaire et al paper. To view this article, visit https://doi.org/10.1111/apt.17599…”
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Multivalent counterions diminish the lubricity of polyelectrolyte brushes by Yu, J, Jackson, N E, Xu, X, Morgenstern, Y, Kaufman, Y, Ruths, M, de Pablo, J J, Tirrell, M

“…Polyelectrolyte brushes provide wear protection and lubrication in many technical, medical, physiological, and biological applications. Wear resistance and low…”
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Southern Hemisphere westerlies as a driver of the early deglacial atmospheric CO2 rise by Menviel, L., Spence, P., Yu, J., Chamberlain, M. A., Matear, R. J., Meissner, K. J., England, M. H.

“…The early part of the last deglaciation is characterised by a ~40 ppm atmospheric CO 2 rise occurring in two abrupt phases. The underlying mechanisms driving…”
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Covalently circularized nanodiscs for studying membrane proteins and viral entry by Nasr, Mahmoud L, Baptista, Diego, Strauss, Mike, Sun, Zhen-Yu J, Grigoriu, Simina, Huser, Sonja, Plückthun, Andreas, Hagn, Franz, Walz, Thomas, Hogle, James M, Wagner, Gerhard

“…Membrane proteins can be stabilized in a native-like setting using lipid-bilayer-based nanodiscs encircled by a membrane scaffold protein. Covalently…”
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Resonant Absorption of Magnetohydrodynamic Body Modes under Photospheric Conditions by Yu, D. J.

“…Abstract Observations reveal that surface and body modes exist in solar pores under photospheric conditions. While the effects of resonant absorption on…”
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Spatial sensitivity analysis of multi-criteria weights in GIS-based land suitability evaluation by Chen, Y., Yu, J., Khan, S.

“…With growing interest in extending GIS to support multi-criteria decision-making (MCDM) methods, enhancing GIS-based MCDM with sensitivity analysis (SA)…”
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Diagnostic Accuracy and Failure Mode Analysis of a Deep Learning Algorithm for the Detection of Cervical Spine Fractures by Voter, A F, Larson, M E, Garrett, J W, Yu, J-P J

“…Artificial intelligence decision support systems are a rapidly growing class of tools to help manage ever-increasing imaging volumes. The aim of this study was…”
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FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation by Tong, J, Tan, S, Zou, F, Yu, J, Zhang, L

“…Colorectal cancer (CRC), the second leading cause of cancer-related deaths in the US, has been treated with targeted therapies. However, the mechanisms of…”
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The population genetics of partial diapause, with applications to the aestivating malaria mosquito Anopheles coluzzii by Mwima, Rita, Hui, Tin‐Yu J., Kayondo, Jonathan K., Burt, Austin

“…Diapause, a form of dormancy to delay or halt the reproductive development during unfavourable seasons, has evolved in many insect species. One example is…”
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Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation by Fuchs, Silke, Garrood, William T, Beber, Anna, Hammond, Andrew, Galizi, Roberto, Gribble, Matthew, Morselli, Giulia, Hui, Tin-Yu J, Willis, Katie, Kranjc, Nace, Burt, Austin, Crisanti, Andrea, Nolan, Tony

“…CRISPR-based homing gene drives can be designed to disrupt essential genes whilst biasing their own inheritance, leading to suppression of mosquito populations…”
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Microbial diversity in biofilms on water distribution pipes of different materials by Yu, J, Kim, D, Lee, T

“…The effects of pipe materials on biofilm formation potential (BFP) and microbial communities in biofilms were analyzed. Pipe coupons made of six different…”
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FOXA1 inhibits prostate cancer neuroendocrine differentiation by Kim, J, Jin, H, Zhao, J C, Yang, Y A, Li, Y, Yang, X, Dong, X, Yu, J

“…Neuroendocrine prostate cancer (NEPC) has increasingly become a clinical challenge. The mechanisms by which neuroendocrine (NE) cells arises from prostate…”
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Dissipative Instability of Magnetohydrodynamic Sausage Waves in a Compressional Cylindrical Plasma: Effect of Flow Shear and Viscosity Shear by Yu, D. J.

“…Abstract The shear flow influences the stability of magnetohydrodynamic (MHD) waves. In the presence of a dissipation mechanism, flow shear may induce an MHD…”
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