Search Results - "J. Stephen Dumler"

State of the art of diagnosis of rickettsial diseases: the use of blood specimens for diagnosis of scrub typhus, spotted fever group rickettsiosis, and murine typhus by Paris, Daniel H, Dumler, J Stephen

“…PURPOSE OF REVIEWWith improved malaria control, acute undifferentiated febrile illness studies in tropical regions reveal a startling proportion of rickettsial…”
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Human Granulocytic Anaplasmosis by Bakken, Johan S., MD, PhD, Dumler, J. Stephen, MD

“…Human granulocytic anaplasmosis, a deer tick–transmitted rickettsial infection caused by Anaplasma phagocytophilum , is a common cause of undifferentiated…”
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Optimization and Evaluation of a Multiplex Quantitative PCR Assay for Detection of Nucleic Acids in Human Blood Samples from Patients with Spotted Fever Rickettsiosis, Typhus Rickettsiosis, Scrub Typhus, Monocytic Ehrlichiosis, and Granulocytic Anaplasmosis by Reller, Megan E, Dumler, J Stephen

“…Spotted fever group rickettsioses (SFGR), typhus group rickettsioses (TGR), scrub typhus (caused by ), ehrlichiosis, and anaplasmosis often present as…”
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Human infection with a novel tick-borne Anaplasma species in China: a surveillance study by Li, Hao, PhD, Zheng, Yuan-Chun, Prof, Ma, Lan, MS, Jia, Na, MD, Jiang, Bao-Gui, PhD, Jiang, Rui-Ruo, MS, Huo, Qiu-Bo, MS, Wang, Ya-Wei, MS, Liu, Hong-Bo, MS, Chu, Yan-Li, BS, Song, Yu-Dong, BS, Yao, Nan-Nan, BS, Sun, Tie, Prof, Zeng, Fan-Yi, Prof, Dumler, J Stephen, Prof, Jiang, Jia-Fu, PhD, Cao, Wu-Chun, Prof

“…Summary Background Anaplasma phagocytophilum and Anaplasma ovis cause human infections. We investigated the potential for human pathogenicity of a newly…”
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Evidence of Orientia spp. Endemicity among Severe Infectious Disease Cohorts, Uganda by Blair, Paul W, Kobba, Kenneth, Okello, Stephen, Alharthi, Sultanah, Naluyima, Prossy, Clemens, Emily, Kibuuka, Hannah, Clark, Danielle V, Kakooza, Francis, Lamorde, Mohammed, Manabe, Yukari C, Dumler, J Stephen, Illness, Acute Febrile

“…At 3 severe infection cohort sites in Uganda, Orientia seropositivity was common. We identified 4 seroconversion cases and 1 PCR-positive case. These results…”
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Clinical Diagnosis and Treatment of Human Granulocytotropic Anaplasmosis by BAKKEN, JOHAN S., DUMLER, J. STEPHEN

“…:  Tick‐borne rickettsiae in the genera Ehrlichia and Anaplasma are intracellular bacteria that infect wild and domestic mammals and, more recently, man. The…”
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Benidipine impairs innate immunity converting sublethal to lethal infections in a murine model of spotted fever rickettsiosis by Londoño, Andrés F, Farner, Jennifer M, Dillon, Marlon, Grab, Dennis J, Kim, Yuri, Scorpio, Diana G, Dumler, J Stephen

“…Spotted fever group rickettsiae are tick-borne obligate intracellular bacteria that infect microvascular endothelial cells. Humans and mammalian infection…”
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Ehrlichioses in Humans: Epidemiology, Clinical Presentation, Diagnosis, and Treatment by Dumler, J. Stephen, Madigan, John E., Pusterla, Nicola, Bakken, Johan S.

“…Human ehrlichioses are emerging tickborne infections. “Human ehrlichiosis” describes infections with at least 5 separate obligate intracellular bacteria in 3…”
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The Clinical Assessment, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: Clinical Practice Guidelines by the Infectious Diseases Society of America by Wormser, Gary P., Dattwyler, Raymond J., Shapiro, Eugene D., Halperin, John J., Steere, Allen C., Klempner, Mark S., Krause, Peter J., Bakken, Johan S., Strle, Franc, Stanek, Gerold, Bockenstedt, Linda, Fish, Durland, Dumler, J. Stephen, Nadelman, Robert B.

“…Evidence-based guidelines for the management of patients with Lyme disease, human granulocytic anaplasmosis (formerly known as human granulocytic…”
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Short-term malaria reduction by single-dose azithromycin during mass drug administration for trachoma, Tanzania by Schachterle, Stephen E, Mtove, George, Levens, Joshua P, Clemens, Emily, Shi, Lirong, Raj, Amrita, Dumler, J Stephen, Munoz, Beatriz, West, Shelia, Sullivan, David J

“…Single-dose mass drug administration of azithromycin (AZT) is underway to eliminate trachoma worldwide. Studies in Ethiopia showed a reduction in all-cause…”
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Chromatin‐bound bacterial effector ankyrin A recruits histone deacetylase 1 and modifies host gene expression by Rennoll‐Bankert, Kristen E., Garcia‐Garcia, Jose C., Sinclair, Sara H., Dumler, J. Stephen

“…Summary Control of host epigenetics is becoming evident as a mechanism by which symbionts and pathogens survive. Anaplasma phagocytophilum, an obligate…”
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The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation by Wang, Xiaowei, Shaw, Dana K, Sakhon, Olivia S, Snyder, Greg A, Sundberg, Eric J, Santambrogio, Laura, Sutterwala, Fayyaz S, Dumler, J Stephen, Shirey, Kari Ann, Perkins, Darren J, Richard, Katharina, Chagas, Andrezza C, Calvo, Eric, Kopecký, Jan, Kotsyfakis, Michail, Pedra, Joao H F

“…Tick saliva contains a number of effector molecules that inhibit host immunity and facilitate pathogen transmission. How tick proteins regulate immune…”
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Extensive diversity of Rickettsiales bacteria in two species of ticks from China and the evolution of the Rickettsiales by Kang, Yan-Jun, Diao, Xiu-Nian, Zhao, Gao-Yu, Chen, Ming-Hui, Xiong, Yanwen, Shi, Mang, Fu, Wei-Ming, Guo, Yu-Jiang, Pan, Bao, Chen, Xiao-Ping, Holmes, Edward C, Gillespie, Joseph J, Dumler, Stephen J, Zhang, Yong-Zhen

“…Bacteria of the order Rickettsiales (Alphaproteobacteria) are obligate intracellular parasites that infect species from virtually every major eukaryotic…”
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Metagenomic next generation sequencing of plasma RNA for diagnosis of unexplained, acute febrile illness in Uganda by Kandathil, Abraham J, Blair, Paul W, Lu, Jennifer, Anantharam, Raghavendran, Kobba, Kenneth, Robinson, Matthew L, Alharthi, Sultanah, Ndawula, Edgar C, Dumler, J Stephen, Kakooza, Francis, Lamorde, Mohammed, Thomas, David L, Salzberg, Steven L, Manabe, Yukari C

“…Metagenomic next generation metagenomic sequencing (mNGS) has proven to be a useful tool in the diagnosis and identification of novel human pathogens and…”
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Innate immunity in rickettsial infections by Londoño, Andrés F, Scorpio, Diana G, Dumler, J Stephen

“…Rickett ial agents are a diverse group of alpha-proteobacteria within the order Rickettsiales, which possesses two families with human pathogens,…”
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Assessing the use of a micro-sampling device for measuring blood protein levels in healthy subjects and COVID-19 patients by Brandsma, Joost, Chenoweth, Josh G, Gregory, Melissa K, Krishnan, Subramaniam, Blair, Paul W, Striegel, Deborah A, Mehta, Rittal, Schully, Kevin L, Dumler, J. Stephen, Sikorski, CDR Cynthia S, O'Connor, Kelsey, Reichert-Scrivner, Susan A, Paguirigan, Carmen M, Uyehara, Catherine F. T, Ngauy, COL Viseth, Myers, Christopher A, Clark, Danielle V

“…Background Venous phlebotomy performed by trained personnel is critical for patient diagnosis and monitoring of chronic disease, but has limitations in…”
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Death from Transfusion-Transmitted Anaplasmosis, New York, USA, 2017 by Goel, Ruchika, Westblade, Lars F, Kessler, Debra A, Sfeir, Maroun, Slavinski, Sally, Backenson, Bryon, Gebhardt, Linda, Kane, Kathleen, Laurence, Jeffrey, Scherr, Douglas, Bussel, James, Dumler, J Stephen, Cushing, Melissa M

“…We report a death from transfusion-transmitted anaplasmosis in a 78-year-old man. The patient died of septic shock 2 weeks after a perioperative transfusion…”
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Anaplasma phagocytophilum Ankyrin A Protein (AnkA) Enters the Nucleus Using an Importin-β-, RanGTP-Dependent Mechanism by Kim, Yuri, Wang, Jianyang, Clemens, Emily G, Grab, Dennis J, Dumler, J Stephen

“…, a tick-borne obligately intracellular bacterium of neutrophils, causes human granulocytic anaplasmosis. Ankyrin A (AnkA), an effector protein with multiple…”
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Distinct Host Species Correlate with Anaplasma phagocytophilum ankA Gene Clusters by Scharf, Wiebke, Schauer, Sonja, Freyburger, Felix, Petrovec, Miroslav, Schaarschmidt-Kiener, Daniel, Liebisch, Gabriele, Runge, Martin, Ganter, Martin, Kehl, Alexandra, Dumler, J. Stephen, Garcia-Perez, Ana L, Jensen, Jennifer, Fingerle, Volker, Meli, Marina L, Ensser, Armin, Stuen, Snorre, von Loewenich, Friederike D

“…Anaplasma phagocytophilum is a Gram-negative, tick-transmitted, obligate intracellular bacterium that elicits acute febrile diseases in humans and domestic…”
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Host-response transcriptional biomarkers accurately discriminate bacterial and viral infections of global relevance by Ko, Emily R., Reller, Megan E., Tillekeratne, L. Gayani, Bodinayake, Champica K., Miller, Cameron, Burke, Thomas W., Henao, Ricardo, McClain, Micah T., Suchindran, Sunil, Nicholson, Bradly, Blatt, Adam, Petzold, Elizabeth, Tsalik, Ephraim L., Nagahawatte, Ajith, Devasiri, Vasantha, Rubach, Matthew P., Maro, Venance P., Lwezaula, Bingileki F., Kodikara-Arachichi, Wasantha, Kurukulasooriya, Ruvini, De Silva, Aruna D., Clark, Danielle V., Schully, Kevin L., Madut, Deng, Dumler, J. Stephen, Kato, Cecilia, Galloway, Renee, Crump, John A., Ginsburg, Geoffrey S., Minogue, Timothy D., Woods, Christopher W.

“…Diagnostic limitations challenge management of clinically indistinguishable acute infectious illness globally. Gene expression classification models show great…”
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