Search Results - "J. Pownall, Henry"

E-selectin-targeting delivery of microRNAs by microparticles ameliorates endothelial inflammation and atherosclerosis by Ma, Shuangtao, Tian, Xiao Yu, Zhang, Yunrong, Mu, Chaofeng, Shen, Haifa, Bismuth, Jean, Pownall, Henry J., Huang, Yu, Wong, Wing Tak

“…E-selectin is a surface marker of endothelial cell (EC) inflammation, one of the hallmarks of atherogenesis. Thus, we tested the hypothesis that delivery of…”
Get full text

Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function by Gupte, Anisha A., Hamilton, Dale J., Pownall, Henry J.

“…Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and…”
Get full text

ABCA1-Derived Nascent High-Density Lipoprotein-Apolipoprotein AI and Lipids Metabolically Segregate by Xu, Bingqing, Gillard, Baiba K, Gotto, Jr, Antonio M, Rosales, Corina, Pownall, Henry J

“…Reverse cholesterol transport comprises cholesterol efflux from ABCA1-expressing macrophages to apolipoprotein (apo) AI, giving nascent high-density…”
Get full text

Serum opacity factor rescues fertility among female Scarb1−/− mice by reducing HDL-free cholesterol bioavailability by Rosales, Corina, Yelamanchili, Dedipya, Gillard, Baiba K., Liu, Jing, Gotto, Antonio M., Pownall, Henry J.

“…Human female infertility, 20% of which is idiopathic, is a public health problem for which better diagnostics and therapeutics are needed. A novel cause of…”
Get full text

Serum Opacity Factor Normalizes Erythrocyte Morphology in Scarb1-/- Mice in an HDL-Free Cholesterol-Dependent Way by Wang, Ziyi, Yelamanchili, Dedipya, Liu, Jing, Gotto, Antonio M., Rosales, Corina, Gillard, Baiba K., Pownall, Henry J.

“…Compared to wild-type (WT) mice, high-density lipoprotein (HDL)-receptor-deficient (Scarb1-/-) mice have higher plasma levels of free cholesterol (FC)-rich HDL…”
Get full text

An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis by Abe, Jun-ichi, Imanishi, Masaki, Li, Shengyu, Zhang, Aijun, Ko, Kyung Ae, Samanthapudi, Venkata S.K., Lee, Ling-Ling, Bojorges, Angelica Paniagua, Gi, Young Jin, Hobbs, Brian P., Deswal, Anita, Herrmann, Joerg, Lin, Steven H., Chini, Eduardo N., Shen, Ying H., Schadler, Keri L., Nguyen, Thi-Hong-Minh, Gupte, Anisha A., Reyes-Gibby, Cielito, Yeung, Sai-Ching J., Abe, Rei J., Olmsted-Davis, Elizabeth A., Krishnan, Sunil, Dantzer, Robert, Palaskas, Nicolas L., Cooke, John P., Pownall, Henry J., Yoshimoto, Momoko, Fujiwara, Keigi, Hamilton, Dale J., Burks, Jared K., Wang, Guangyu, Le, Nhat-Tu, Kotla, Sivareddy

“…ERK5 (extracellular signal-regulated kinase 5) is a dual kinase transcription factor containing an N-terminal kinase domain and a C-terminal transcriptional…”
Get full text

Structural basis of transfer between lipoproteins by cholesteryl ester transfer protein by Zhang, Lei, Yan, Feng, Zhang, Shengli, Lei, Dongsheng, Charles, M Arthur, Cavigiolio, Giorgio, Oda, Michael, Krauss, Ronald M, Weisgraber, Karl H, Rye, Kerry-Anne, Pownall, Henry J, Qiu, Xiayang, Ren, Gang

“…Optimized negative-staining and cryo–positive staining EM reveals that human cholesteryl ester transfer protein penetrates into HDL and LDL from each distal…”
Get full text

Dietary Alcohol and Fat Differentially Affect Plasma Cholesteryl Ester Transfer Activity and Triglycerides in Normo‐ and Hypertriglyceridemic Subjects by Gaubatz, John W., Gillard, Baiba K., Rosales, Corina, Pownall, Henry J.

“…Moderate alcohol consumption is associated with increased plasma high‐density lipoprotein (HDL)‐cholesterol concentrations and reduced risk for cardiovascular…”
Get full text

Morphology and structure of lipoproteins revealed by an optimized negative-staining protocol of electron microscopy[S] by Zhang, Lei, Song, James, Cavigiolio, Giorgio, Ishida, Brian Y., Zhang, Shengli, Kane, John P., Weisgraber, Karl H., Oda, Michael N., Rye, Kerry-Anne, Pownall, Henry J., Ren, Gang

“…Plasma lipoprotein levels are predictors of risk for coronary artery disease. Lipoprotein structure-function relationships provide important clues that help…”
Get full text

Direct Measurement of the Structure of Reconstituted High-Density Lipoproteins by Cryo-EM by Murray, Stephen C., Gillard, Baiba K., Ludtke, Steven J., Pownall, Henry J.

“…Early forms of high-density lipoproteins (HDL), nascent HDL, are formed by the interaction of apolipoprotein AI with macrophage and hepatic ATP-binding…”
Get full text

Hyperhomocysteinemia Decreases Circulating High-Density Lipoprotein by Inhibiting Apolipoprotein A-I Protein Synthesis and Enhancing HDL Cholesterol Clearance by Liao, Dan, Tan, Hongmei, Hui, Rutai, Li, Zhaohui, Jiang, Xiaohua, Gaubatz, John, Yang, Fan, Durante, William, Chan, Lawrence, Schafer, Andrew I, Pownall, Henry J, Yang, Xiaofeng, Wang, Hong

“…We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor of coronary artery disease (CAD), is associated with increased…”
Get full text

Model of Human Low-Density Lipoprotein and Bound Receptor Based on CryoEM by Ren, Gang, Rudenko, Gabby, Ludtke, Steven J., Deisenhofer, Johann, Chiu, Wah, Pownall, Henry J., Havel, Richard J.

“…Human plasma low-density lipoproteins (LDL), a risk factor for cardiovascular disease, transfer cholesterol from plasma to liver cells via the LDL receptor…”
Get full text

Shear-induced Disulfide Bond Formation Regulates Adhesion Activity of von Willebrand Factor by Choi, Hiuwan, Aboulfatova, Khatira, Pownall, Henry J., Cook, Richard, Dong, Jing-fei

“…von Willebrand factor (VWF) is the largest multimeric adhesion ligand circulating in blood. Its adhesion activity is related to multimer size, with the…”
Get full text

The Alcohol-High-Density Lipoprotein Athero-Protective Axis by Rosales, Corina, Gillard, Baiba K, Gotto, Jr, Antonio M, Pownall, Henry J

“…Ingestion of alcohol is associated with numerous changes in human energy metabolism, especially that of plasma lipids and lipoproteins. Regular moderate…”
Get full text

Mechanism of LDL binding and release probed by structure-based mutagenesis of the LDL receptor[S] by Huang, Sha, Henry, Lisa, Ho, Yiu Kee, Pownall, Henry J., Rudenko, Gabby

“…The LDL receptor (LDL-R) mediates cholesterol metabolism in humans by binding and internalizing cholesterol transported by LDL. Several different molecular…”
Get full text

Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I by Massey, John B., Pownall, Henry J.

“…Formation of discoidal high density lipoproteins (rHDL) by apolipoprotein A-I (apoA-I) mediated solubilization of dimyristoyl phosphatidylcholine (DMPC)…”
Get full text

Poloxamer 407 Induces Hypertriglyceridemia but Decreases Atherosclerosis in Ldlr -/- Mice by Peng, Xueying, Lian, Zeqin, Perrard, Xiao-Yuan Dai, Xiao, Yunjie, Ni, Jing, O'Brien, Veronica, Dong, Henry, Pownall, Henry J, Ballantyne, Christie M, Wu, Huaizhu

“…Hypertriglyceridemia (HTG) increases the risk for atherosclerotic cardiovascular disease, but underlying mechanisms are incompletely understood. Circulating…”
Get full text

Commentary on SSO and other putative inhibitors of FA transport across membranes by CD36 disrupt intracellular metabolism, but do not affect fatty acid translocation by Pownall, Henry J

Get full text

The Polar Nature of 7-Ketocholesterol Determines Its Location within Membrane Domains and the Kinetics of Membrane Microsolubilization by Apolipoprotein A-I by Massey, John B, Pownall, Henry J

“…7-Ketocholesterol is an oxidized derivative of cholesterol with numerous physiological effects. In model membranes, 7-ketocholesterol and cholesterol were…”
Get full text

Apolipoprotein E Mediates Enhanced Plasma High-Density Lipoprotein Cholesterol Clearance by Low-Dose Streptococcal Serum Opacity Factor via Hepatic Low-Density Lipoprotein Receptors In Vivo by Rosales, Corina, Tang, Daming, Gillard, Baiba K, Courtney, Harry S, Pownall, Henry J

“…OBJECTIVE—Recombinant streptococcal serum opacity factor (rSOF) mediates the in vitro disassembly of human plasma high-density lipoprotein (HDL) into…”
Get full text