Search Results - "J. Hoy"
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N -Aryl–linked spirocyclic polymers for membrane separations of complex hydrocarbon mixtures
Published in Science (American Association for the Advancement of Science) (17-07-2020)“…Separating organics without distillation Hydrocarbon distillation is a widespread and energy-intensive process. Membranes might offer an alternative approach,…”
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The diversity and breadth of cancer cell fatty acid metabolism
Published in Cancer & metabolism (07-01-2021)“…Tumor cellular metabolism exhibits distinguishing features that collectively enhance biomass synthesis while maintaining redox balance and cellular…”
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Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer
Published in Seminars in cancer biology (01-10-2016)“…Abstract Prostate cancer (PCa), a hormonally-driven cancer, ranks first in incidence and second in cancer related mortality in men in most Western…”
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Lipid metabolism in skeletal muscle: generation of adaptive and maladaptive intracellular signals for cellular function
Published in American journal of physiology: endocrinology and metabolism (01-06-2012)“…Fatty acids derived from adipose tissue lipolysis, intramyocellular triacylglycerol lipolysis, or de novo lipogenesis serve a variety of functions in skeletal…”
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Lipid and glucose metabolism in hepatocyte cell lines and primary mouse hepatocytes: a comprehensive resource for in vitro studies of hepatic metabolism
Published in American journal of physiology: endocrinology and metabolism (01-04-2019)“…The liver is a critical tissue for maintaining glucose, fatty acid, and cholesterol homeostasis. Primary hepatocytes represent the gold standard for studying…”
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Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism
Published in Cell metabolism (01-12-2015)“…Liver steatosis is associated with the development of insulin resistance and the pathogenesis of type 2 diabetes. We tested the hypothesis that protein signals…”
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Frailty, the Next Obstacle to Achieve Healthy Aging in People with Human Immunodeficiency Virus
Published in The Journal of infectious diseases (17-08-2020)Get full text
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Human DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis
Published in eLife (20-07-2020)“…Fatty acid β-oxidation (FAO) is the main bioenergetic pathway in human prostate cancer (PCa) and a promising novel therapeutic vulnerability. Here we…”
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Ceramides Contained in LDL Are Elevated in Type 2 Diabetes and Promote Inflammation and Skeletal Muscle Insulin Resistance
Published in Diabetes (New York, N.Y.) (01-02-2013)“…Dysregulated lipid metabolism and inflammation are linked to the development of insulin resistance in obesity, and the intracellular accumulation of the…”
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Peri‐prostatic adipose tissue: the metabolic microenvironment of prostate cancer
Published in BJU international (01-05-2018)“…Emerging data have linked certain features of clinical prostate cancer (PCa) to obesity and, more specifically, increased adiposity. Whereas the large number…”
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GCKIII kinases control hepatocellular lipid homeostasis via shared mode of action
Published in Journal of lipid research (01-11-2024)“…Metabolic dysfunction–associated steatotic liver disease has emerged as a leading global cause of chronic liver disease. Our recent translational…”
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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents
Published in Nature communications (19-09-2019)“…Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive…”
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Insulin resistance is a cellular antioxidant defense mechanism
Published in Proceedings of the National Academy of Sciences - PNAS (20-10-2009)“…We know a great deal about the cellular response to starvation via AMPK, but less is known about the reaction to nutrient excess. Insulin resistance may be an…”
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Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver[S]
Published in Journal of lipid research (01-02-2020)“…Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide and have been…”
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Recovery from Mosaic Caused by Sorghum Mosaic Virus in Sugarcane and Impact on Yield
Published in Plant disease (01-12-2020)“…Mosaic is a historically important viral disease of sugarcane in Louisiana caused by Sugarcane mosaic virus and, currently, by Sorghum mosaic virus (SrMV)…”
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Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration
Published in Cancer & metabolism (13-01-2017)“…Obesity is associated with increased recurrence and reduced survival of breast cancer. Adipocytes constitute a significant component of breast tissue, yet…”
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Linking Late Endosomal Cholesterol with Cancer Progression and Anticancer Drug Resistance
Published in International journal of molecular sciences (01-07-2022)“…Cancer cells undergo drastic metabolic adaptions to cover increased bioenergetic needs, contributing to resistance to therapies. This includes a higher demand…”
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Extracellular Fatty Acids Are the Major Contributor to Lipid Synthesis in Prostate Cancer
Published in Molecular cancer research (01-04-2019)“…Prostate cancer cells exhibit altered cellular metabolism but, notably, not the hallmarks of Warburg metabolism. Prostate cancer cells exhibit increased…”
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Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin Resistance
Published in Diabetes (New York, N.Y.) (01-03-2009)“…Overexpression of Carnitine Palmitoyltransferase-1 in Skeletal Muscle Is Sufficient to Enhance Fatty Acid Oxidation and Improve High-Fat Diet–Induced Insulin…”
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A place-based approach to payments for ecosystem services
Published in Global environmental change (01-03-2017)“…•We introduce and define a place-based approach to Payment for Ecosystem Services (PES).•The approach incorporates multi-level governance, bundling and shared…”
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