Search Results - "J. Flanagan, Keith"

Generation of Triplet Excited States via Photoinduced Electron Transfer in meso-anthra-BODIPY: Fluorogenic Response toward Singlet Oxygen in Solution and in Vitro by Filatov, Mikhail A, Karuthedath, Safakath, Polestshuk, Pavel M, Savoie, Huguette, Flanagan, Keith J, Sy, Cindy, Sitte, Elisabeth, Telitchko, Maxime, Laquai, Frédéric, Boyle, Ross W, Senge, Mathias O

“…Heavy atom-free BODIPY-anthracene dyads (BADs) generate locally excited triplet states by way of photoinduced electron transfer (PeT), followed by…”
Get full text

Nonplanar Porphyrins by N‐Substitution: A Neglected Pathway by Roucan, Marie, Flanagan, Keith J., O'Brien, John, Senge, Mathias O.

“…N‐substitution of porphyrins has been a neglected route towards nonplanar porphyrins for the past decades. Previously, they featured in a host of potential…”
Get full text

Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles by Abdel-Mohsen, Heba T, Abdullaziz, Mona A, Kerdawy, Ahmed M El, Ragab, Fatma A F, Flanagan, Keith J, Mahmoud, Abeer E E, Ali, Mamdouh M, Diwani, Hoda I El, Senge, Mathias O

“…In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our…”
Get full text

Cubane Cross‐Coupling and Cubane–Porphyrin Arrays by Bernhard, Stefan S. R., Locke, Gemma M., Plunkett, Shane, Meindl, Alina, Flanagan, Keith J., Senge, Mathias O.

“…Herein, an improved methodology for aryl‐cubane cross‐coupling is reported. The peculiarities of the cubane core and its behavior during cross‐coupling…”
Get full text

Weak Interactions and Conformational Changes in Core-Protonated A2- and Ax-Type Porphyrin Dications by Kingsbury, Christopher J., Flanagan, Keith J., Eckhardt, Hans-Georg, Kielmann, Marc, Senge, Mathias O.

“…Individual chemical motifs are known to introduce structural distortions to the porphyrin macrocycle, be it in the core or at the periphery of the macrocycle…”
Get full text

Synthesis of a Family of Highly Substituted Porphyrin Thioethers via Nitro Displacement in 2,3,7,8,12,13,17,18-Octaethyl-5,10,15,20-tetranitroporphyrin by Kielmann, Marc, Flanagan, Keith J, Norvaiša, Karolis, Intrieri, Daniela, Senge, Mathias O

“…A series of highly substituted porphyrin thioethers was synthesized from 2,3,7,8,12,13,17,18-octaethyl-5,10,15,20-tetranitroporphyrin (H2OETNP). The reactions…”
Get full text

Functionalization of Deutero- and Protoporphyrin IX Dimethyl Esters via Palladium-Catalyzed Coupling Reactions by O’Brien, Jessica M, Sitte, Elisabeth, Flanagan, Keith J, Kühner, Hannes, Hallen, Lukas J, Gibbons, Dáire, Senge, Mathias O

“…Herein, we report the functionalization of the β-positions of deutero- and protoporphyrin IX dimethyl esters. Initial halogenations were carried out on both…”
Get full text

Nucleophilic Aromatic Substitution on Pentafluorophenyl-Substituted Dipyrranes and Tetrapyrroles as a Route to Multifunctionalized Chromophores for Potential Application in Photodynamic Therapy by Gutsche, Claudia S., Ortwerth, Marlene, Gräfe, Susanna, Flanagan, Keith J., Senge, Mathias O., Reissig, Hans-Ulrich, Kulak, Nora, Wiehe, Arno

“…The application of porphyrinoids in biomedical fields, such as photodynamic therapy (PDT), requires the introduction of functional groups to tune their…”
Get full text

Towards triptycene functionalization and triptycene-linked porphyrin arrays by Locke, Gemma M, Flanagan, Keith J, Senge, Mathias O

“…Herein, 9,10-diethynyltriptycene is investigated for its use as a rigid isolating unit in the synthesis of multichromophoric arrays. Sonogashira cross-coupling…”
Get full text

Structural effects of meso-halogenation on porphyrins by Flanagan, Keith J, Paradiz Dominguez, Maximilian, Melissari, Zoi, Eckhardt, Hans-Georg, Williams, René M, Gibbons, Dáire, Prior, Caroline, Locke, Gemma M, Meindl, Alina, Ryan, Aoife A, Senge, Mathias O

“…The use of halogens in the crystal engineering of supramolecular porphyrin assemblies has been a topic of strong interest over the past decades. With this in…”
Get full text

Conformational Re‐engineering of Porphyrins as Receptors with Switchable N−H⋅⋅⋅X‐Type Binding Modes by Norvaiša, Karolis, Flanagan, Keith J., Gibbons, Dáire, Senge, Mathias O.

“…The selectivity and functional variability of porphyrin cofactors are typically based on substrate binding of metalloporphyrins wherein the pyrrole nitrogen…”
Get full text

Diagnosis of Porcine teschovirus encephalomyelitis in the Republic of Haiti by Deng, Ming Y., Millien, Max, Jacques-Simon, Rodney, Flanagan, J. Keith, Bracht, Alexa J., Carrillo, Consuelo, Barrette, Roger W., Fabian, Andrew, Mohamed, Fawzi, Moran, Karen, Rowland, Jessica, Swenson, Sabrina L., Jenkins-Moore, Melinda, Koster, Leo, Thomsen, Bruce V., Mayr, Gregory, Pyburn, Dave, Morales, Paula, Shaw, John, Burrage, Thomas, White, William, McIntosh, Michael T., Metwally, Samia

“…In February and March 2009, approximately 1,500 backyard pigs of variable age became sick, and approximately 700 of them died or were euthanized in the Lower…”
Get full text

Dipyrrinato‐Iridium(III) Complexes for Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation by Hohlfeld, Benjamin F., Gitter, Burkhard, Kingsbury, Christopher J., Flanagan, Keith J., Steen, Dorika, Wieland, Gerhard D., Kulak, Nora, Senge, Mathias O., Wiehe, Arno

“…The generation of bio‐targetable photosensitizers is of utmost importance to the emerging field of photodynamic therapy and antimicrobial (photo‐)therapy. A…”
Get full text

Investigating the Impact of Conformational Molecular Engineering on the Crystal Packing of Cavity Forming Porphyrins by Flanagan, Keith J, Twamley, Brendan, Senge, Mathias O

“…Herein we report the synthesis of 5,10,15,20-tetraaryl-(X)-substituted-2,3,7,8,12,13,17,18-octaethylporphyrins (OETArXPs) and a structural investigation of…”
Get full text

Targeted Synthesis of Regioisomerically Pure Dodecasubstituted Type I Porphyrins through the Exploitation of Peri-interactions by Kielmann, Marc, Flanagan, Keith J, Senge, Mathias O

“…A targeted synthesis of dodecasubstituted type I porphyrins that utilizes the reaction of unsymmetrical 3,4-difunctionalized pyrroles and sterically demanding…”
Get full text

Short‐Chained Anthracene Strapped Porphyrins and their Endoperoxides by Callaghan, Susan, Flanagan, Keith J., O'Brien, John E., Senge, Mathias O.

“…The syntheses of short‐chained anthracene‐strapped porphyrins and their Zn(II)complexes are reported. The key synthetic step is a [2+2] condensation between a…”
Get full text

Not Your Usual Bioisostere: Solid State Study of 3D Interactions in Cubanes by Flanagan, Keith J., Bernhard, Stefan S. R., Plunkett, Shane, Senge, Mathias O.

“…Previous studies by Desiraju and co‐workers have implicated the acidic hydrogen atoms of cubane as a support network for hydrogen bonding groups. Herein we…”
Get full text

An Insight into Non‐Covalent Interactions on the Bicyclo[1.1.1]pentane Scaffold by Grover, Nitika, Flanagan, Keith J., Trujillo, Cristina, Kingsbury, Christopher J., Senge, Mathias O.

“…Bicyclo[1.1.1]pentane (BCP) is studied extensively as a bioisosteric component of drugs. Not found in nature, this molecular unit approximates the distance of…”
Get full text

Sterically induced distortions of nickel(II) porphyrins – Comprehensive investigation by DFT calculations and resonance Raman spectroscopy by Schindler, Julian, Kupfer, Stephan, Ryan, Aoife A., Flanagan, Keith J., Senge, Mathias O., Dietzek, Benjamin

“…•Sterically induced out-of-plane distortions of nickel(II)porphyrins.•Prediction of out-of-plane distortions by theoretical and experimental…”
Get full text

Synthesis of Porphyrinoids, BODIPYs, and (Dipyrrinato)ruthenium(II) Complexes from Prefunctionalized Dipyrromethanes by Hohlfeld, Benjamin F., Flanagan, Keith J., Kulak, Nora, Senge, Mathias O., Christmann, Mathias, Wiehe, Arno

“…The introduction of functional groups into the meso‐position of dipyrromethanes, boron‐dipyrromethenes (BODIPYs) and porphyrinoids, is of fundamental…”
Get full text