Search Results - "J. Alain Kummer"

Orphan granzymes find a home by Bovenschen, Niels, Kummer, J. Alain

“…Cytotoxic lymphocytes are armed with granules that are released in the granule-exocytosis pathway to kill tumor cells and virus-infected cells. Cytotoxic…”
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Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response by Kummer, J. Alain, Broekhuizen, Roel, Everett, Helen, Agostini, Laetitia, Kuijk, Loes, Martinon, Fabio, van Bruggen, Robin, Tschopp, Jurg

“…Several autoinflammatory disorders such as Muckle-Wells syndrome are characterized by mutations in the NALP3/cryopyrin gene. NALP3 and NALP1 proteins can…”
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Incidence of significant prostate cancer after negative MRI and systematic biopsy in the FUTURE trial by Exterkate, Leonie, Wegelin, Olivier, Barentsz, Jelle O., Leest, Marloes G., Kummer, J. Alain, Vreuls, Willem, Bruin, Peter C., Witjes, J. Alfred, Melick, Harm H.E., Somford, Diederik M.

“…Objectives To assess the proportion of clinically significant (cs) prostate cancer (PCa) found during follow‐up in patients with negative systematic biopsy…”
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Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae by Simons, Peter J., Kummer, J. Alain, Luiken, Joost J.F.P., Boon, Louis

“…CD36 is the receptor for long chain fatty acids (LCFA), and is expressed in lingual taste cells from rodents. In these animals, CD36 has been proposed to play…”
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Notch1 functions as a tumor suppressor in mouse skin by Wolfer, Anita, Radtke, Freddy, Nicolas, Michael, Dotto, G. Paolo, Kummer, J. Alain, Mill, Pleasantine, Clevers, Hans, van Noort, Mascha, Hui, Chi-chung, Raj, Kenneth

“…Notch proteins are important in binary cell-fate decisions and inhibiting differentiation in many developmental systems, and aberrant Notch signaling is…”
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Granzyme K Displays Highly Restricted Substrate Specificity That Only Partially Overlaps with Granzyme A by Bovenschen, Niels, Quadir, Razi, van den Berg, A. Lotte, Brenkman, Arjan B., Vandenberghe, Isabel, Devreese, Bart, Joore, Jos, Kummer, J. Alain

“…Granzymes are serine proteases stored in cytolytic granules of cytotoxic lymphocytes that eliminate virus-infected and tumor cells. Little is known about the…”
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Validation of a Gene Expression Signature for Assessment of Lymph Node Metastasis in Oral Squamous Cell Carcinoma by HOOFF, Sander R. Van, LEUSINK, Frank K. J, KUMMER, J. Alain, LEEMANS, C. René, SCHUURING, Ed, LANGENDIJK, Johannes A, LACKO, Martin, DE HERDT, Maria J, JANSEN, Jeroen C, BRAKENHOFF, Ruud H, SLOOTWEG, Piet J, TAKES, Robert P, ROEPMAN, Paul, HOLSTEGE, Frank C. P, DE JONG, Robert J. Baatenburg, SPEEL, Ernst-Jan M, DEN BREKEL, Michiel W. M. Van, VELTHUYSEN, Marie-Louise F. Van, DIEST, Paul J. Van, ES, Robert J. J. Van, MERKX, Matthias A. W

“…Current assessment of lymph node metastasis in patients with head and neck squamous cell carcinoma is not accurate enough to prevent overtreatment. The aim of…”
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Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death by de Koning, Pieter J A, Kummer, J Alain, de Poot, Stefanie A H, Quadir, Razi, Broekhuizen, Roel, McGettrick, Anne F, Higgins, Wayne J, Devreese, Bart, Worrall, D Margaret, Bovenschen, Niels

“…Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-infected and tumor cells. In humans, five different granzymes (i.e…”
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Performance of Immuno–Positron Emission Tomography with Zirconium-89-Labeled Chimeric Monoclonal Antibody U36 in the Detection of Lymph Node Metastases in Head and Neck Cancer Patients by Börjesson, Pontus K E, Jauw, Yvonne W S, Boellaard, Ronald, de Bree, Remco, Comans, Emile F I, Roos, Jan C, Castelijns, Jonas A, Vosjan, Maria J W D, Kummer, J Alain, Leemans, C René, Lammertsma, Adriaan A, van Dongen, Guus A M S

“…Purpose: Immuno–positron emission tomography (PET), the combination of PET with monoclonal antibodies (mAb), is an attractive option to improve tumor detection…”
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EGFR and KRAS mutations in lung carcinomas in the Dutch population: increased EGFR mutation frequency in malignant pleural effusion of lung adenocarcinoma by Smits, Alexander J. J., Kummer, J. Alain, Hinrichs, John W. J., Herder, Gerarda J. M., Scheidel-Jacobse, Karen C., Jiwa, N. Mehdi, Ruijter, T. Emiel G., Nooijen, Peet T. G. A., Looijen-Salamon, Monica G., Ligtenberg, Marjolijn J. L., Thunnissen, Frederik B., Heideman, Daniëlle A. M., de Weger, Roel A., Vink, Aryan

“…Background Frequencies of EGFR and KRAS mutations in non-small cell lung cancer (NSCLC) have predominantly been determined in East Asian and North American…”
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The Multiple Endocrine Neoplasia Type 1 (MEN1) Tumor Suppressor Regulates Peroxisome Proliferator-Activated Receptor γ-Dependent Adipocyte Differentiation by Dreijerink, Koen M. A., Varier, Radhika A., van Beekum, Olivier, Jeninga, Ellen H., Höppener, Jo W. M., Lips, Cornelis J. M., Kummer, J. Alain, Kalkhoven, Eric, Timmers, H. T. Marc

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human mast cells produce and release the cytotoxic lymphocyte associated protease granzyme B upon activation by Strik, Merel C.M., de Koning, Pieter J.A., Kleijmeer, Monique J., Bladergroen, Bellinda A., Wolbink, Angela M., Griffith, Janice M., Wouters, Dorine, Fukuoka, Yoshihiro, Schwartz, Lawrence B., Hack, C. Erik, van Ham, S. Marieke, Kummer, J. Alain

“…Mast cells are widely distributed throughout the body and express effector functions in allergic reactions, inflammatory diseases, and host defense. Activation…”
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Mutated p53 as a molecular marker for the diagnosis of head and neck cancer by van Houten, Viola MM, Tabor, Maarten P, van den Brekel, Michiel WM, Alain Kummer, J, Denkers, Fedor, Dijkstra, Janny, Leemans, René, van der Waal, Isaäc, Snow, Gordon B, Brakenhoff, Ruud H

“…In total, 10–30% of patients with head and neck squamous cell carcinoma (HNSCC) develop local recurrences despite seemingly adequate tumour resection. This may…”
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Maintenance of head and neck tumor gene expression profiles upon lymph node metastasis by ROEPMAN, Paul, DE JAGER, Alike, GROOT KOERKAMP, Marian J. A, KUMMER, J. Alain, SLOOTWEG, Piet J, HOLSTEGE, Frank C. P

“…Spread of cancer and development of solid metastases at distant sites is the main cause of cancer-related deaths. To understand and treat metastases, it is…”
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Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma by ten Berge, Rosita L., Meijer, Chris J.L.M., Dukers, Danny F., Kummer, J. Alain, Bladergroen, Bellinda A., Vos, Wim, Hack, C. Erik, Ossenkoppele, Gert J., Oudejans, Joost J.

“…In vitro studies suggest that resistance to chemotherapy-induced apoptosis might explain poor response to therapy in fatal cases. Actual execution of apoptosis…”
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Downregulation of SERPINB13 expression in head and neck squamous cell carcinomas associates with poor clinical outcome by de Koning, Pieter J.A., Bovenschen, Niels, Leusink, Frank K.J., Broekhuizen, Roel, Quadir, Razi, van Gemert, Jan T.M., Hordijk, Gerrit J., Chang, Wun‐Shaing W., van der Tweel, Ingeborg, Tilanus, Marcel G.J., Kummer, J. Alain

“…Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human…”
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Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: A potential mechanism for stable renal function in patients with subclinical rejection by Rowshani, Ajda T., Florquin, Sandrine, Bemelman, Frederike, Kummer, J. Alain, Hack, C. Erik, Ten Berge, Ineke J.M.

“…Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: A potential mechanism for stable renal function in patients with subclinical…”
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Expression of Cellular FLICE Inhibitory Protein, Caspase-8, and Protease Inhibitor-9 in Ewing Sarcoma and Implications for Susceptibility to Cytotoxic Pathways by DE HOOGE, Alfons S. K, BERGHUIS, Dagmar, LANKESTER, Arjan C, SANTOS, Susyjusto, MOOIMAN, Esther, ROMEO, Salvatore, ALAIN KUMMER, J, MAARTEN EGELER, R, VAN TOL, Maarten J. D, MELIEF, Cornelis J. M, HOGENDOORN, Pancras C. W

“…Purpose: Ewing sarcoma is a common pediatric bone tumor with an unfavorable prognosis for metastatic or recurrent disease. Cellular immunotherapy may provide…”
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The estimation of tumor cell percentage for molecular testing by pathologists is not accurate by Smits, Alexander J J, Kummer, J Alain, de Bruin, Peter C, Bol, Mijke, van den Tweel, Jan G, Seldenrijk, Kees A, Willems, Stefan M, Offerhaus, G Johan A, de Weger, Roel A, van Diest, Paul J, Vink, Aryan

“…Molecular pathology is becoming more and more important in present day pathology. A major challenge for any molecular test is its ability to reliably detect…”
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Spatial differences in the presence of FOXP3+ and GranzymeB+ T cells between the intra- and extravascular compartments in renal allograft vasculopathy by de Boer, Onno J, Teeling, Peter, Jansen, Marcel, Ploegmakers, Hanneke, van der Loos, Chris M, Kummer, J Alain, Florquin, Sandrine, van der Wal, Allard C

“…Allograft vasculopathy (AV) and native atherosclerosis (NA) share the presence of a T-cell mediated inflammatory response, but differ in overall plaque…”
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