Search Results - "J. -A. Gustafsson"

Estrogen receptor β upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer by Dey, P, Ström, A, Gustafsson, J-Å

“…Estrogen receptor β (ERβ) is emerging as a critical factor in understanding prostate cancer biology. Although reduced in prostate cancer above Gleason grade 3,…”
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A genome-wide study of the repressive effects of estrogen receptor beta on estrogen receptor alpha signaling in breast cancer cells by Williams, C, Edvardsson, K, Lewandowski, S A, Ström, A, Gustafsson, J-Å

“…Transcriptional effects of estrogen result from its activation of two estrogen receptor (ER) isoforms; ER α that drives proliferation and ER β that is…”
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Estrogen receptor β and Liver X receptor β: biology and therapeutic potential in CNS diseases by Warner, M, Gustafsson, J-A

“…In the last decade of the twentieth century, two nuclear receptors were discovered in our laboratory and, very surprisingly, were found to have key roles in…”
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Evidence that oestrogen receptor-α plays an important role in the regulation of glucose homeostasis in mice: insulin sensitivity in the liver by Bryzgalova, G, Gao, H, Ahren, B, Zierath, J.R, Galuska, D, Steiler, T.L, Dahlman-Wright, K, Nilsson, S, Gustafsson, J.-Å, Efendic, S, Khan, A

“…Aims/hypothesis We used oestrogen receptor-α (ERα) knockout (ERKO) and receptor-β (ERβ) knockout (BERKO) mice to investigate the mechanism(s) behind the…”
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ERβ decreases breast cancer cell survival by regulating the IRE1/XBP-1 pathway by Rajapaksa, G, Nikolos, F, Bado, I, Clarke, R, Gustafsson, J-Å, Thomas, C

“…Unfolded protein response (UPR) is an adaptive reaction that allows cancer cells to survive endoplasmic reticulum (EnR) stress that is often induced in the…”
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Liver X receptor β is essential for the differentiation of radial glial cells to oligodendrocytes in the dorsal cortex by Xu, P, Xu, H, Tang, X, Xu, L, Wang, Y, Guo, L, Yang, Z, Xing, Y, Wu, Y, Warner, M, Gustafsson, J-A, Fan, X

“…Several psychiatric disorders are associated with aberrant white matter development, suggesting oligodendrocyte and myelin dysfunction in these diseases. There…”
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Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice by González-Granillo, M., Steffensen, K. R., Granados, O., Torres, N., Korach-André, M., Ortíz, V., Aguilar-Salinas, C., Jakobsson, T., Díaz-Villaseñor, A., Loza-Valdes, A., Hernandez-Pando, R., Gustafsson, J.-Å., Tovar, A. R.

“…Aims/hypothesis Liver X receptor (LXR)α regulates the genes involved in cholesterol, fatty acid and glucose metabolism. Soy protein (SP) consumption reduces…”
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LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile by Hu, X., Steffensen, K. R., Jiang, Z.-Y., Parini, P., Gustafsson, J.-Å., Gåfvels, M., Eggertsen, G.

“…  Hu X, Steffensen KR, Jiang Z‐Y, Parini P, Gustafsson J‐Å, Gåfvels M, Eggertsen G (Karolinska Institutet, Huddinge, Stockholm, Sweden; Karolinska Institutet,…”
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Liver X receptors regulate cerebrospinal fluid production by Dai, Y-b, Wu, W-f, Huang, B, Miao, Y-f, Nadarshina, S, Warner, M, Gustafsson, J-Å

“…Of the two isoforms of Liver X receptor (LXR), LXRβ has been shown to have major effects in the central nervous system (CNS) and on the regulation of…”
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The role of membrane ERα signaling in bone and other major estrogen responsive tissues by Gustafsson, K. L., Farman, H., Henning, P., Lionikaite, V., Movérare-Skrtic, S., Wu, J., Ryberg, H., Koskela, A., Gustafsson, J.-Å., Tuukkanen, J., Levin, E. R., Ohlsson, C., Lagerquist, M. K.

“…Estrogen receptor α (ERα) signaling leads to cellular responses in several tissues and in addition to nuclear ERα-mediated effects, membrane ERα (mERα)…”
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Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain by Sugiyama, N, Andersson, S, Lathe, R, Fan, X, Alonso-Magdalena, P, Schwend, T, Nalvarte, I, Warner, M, Gustafsson, J-Å

“…This study reports on the spatiotemporal dynamics of the expression of estrogen receptors (ERs) in the mouse central nervous system (CNS) during the early…”
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Harnessing the reverse cholesterol transport pathway to favor differentiation of monocyte-derived APCs and antitumor responses by Raccosta, Laura, Marinozzi, Maura, Costantini, Susan, Maggioni, Daniela, Ferreira, Lorena Maria, Corna, Gianfranca, Zordan, Paola, Sorice, Angela, Farinello, Diego, Bianchessi, Silvia, Riba, Michela, Lazarevic, Dejan, Provero, Paolo, Mack, Matthias, Bondanza, Attilio, Nalvarte, Ivan, Gustafsson, J-A, Ranzani, Valeria, De Sanctis, Francesco, Ugel, Stefano, Baron, Silvère, Lobaccaro, Jean-Marc A., Pontini, Lorenzo, Pacciarini, Manuela, Traversari, Catia, Pagani, Massimiliano, Bronte, Vincenzo, Sitia, Giovanni, Antonson, Per, Brendolan, Andrea, Budillon, Alfredo, Russo, Vincenzo

“…Lipid and cholesterol metabolism play a crucial role in tumor cell behavior and in shaping the tumor microenvironment. In particular, enzymatic and…”
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Oestrogen receptors – an overview by Enmark, E., Gustafsson, J.‐Å.

“…Enmark E, Gustafsson J‐A (Karolinska Institutet, Huddinge, Sweden). Oestrogen receptors – an overview (Review). J Intern Med 1999; 246: 133–138. The oestrogen…”
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The estrogen receptor α-selective agonist propyl pyrazole triol improves glucose tolerance in ob/ob mice; potential molecular mechanisms by Lundholm, L, Bryzgalova, G, Gao, H, Portwood, N, Fält, S, Berndt, K D, Dicker, A, Galuska, D, Zierath, J R, Gustafsson, J-Å, Efendic, S, Dahlman-Wright, K, Khan, A

“…The aim of this study was to validate the role of estrogen receptor α (ERα) signaling in the regulation of glucose metabolism, and to compare the molecular…”
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The oxysterol receptor LXRβ protects against DSS- and TNBS-induced colitis in mice by Jakobsson, T, Vedin, L-L, Hassan, T, Venteclef, N, Greco, D, D'Amato, M, Treuter, E, Gustafsson, J-Å, Steffensen, K R

“…We examined the function of the oxysterol receptors (LXRs) in inflammatory bowel disease (IBD) through studying dextran sodium sulfate (DSS)- and…”
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Life-long in vivo cell-lineage tracing shows that no oogenesis originates from putative germline stem cells in adult mice by Zhang, Hua, Liu, Lian, Li, Xin, Busayavalasa, Kiran, Shen, Yan, Hovatta, Outi, Gustafsson, Jan-Åke, Liu, Kui

“…Whether or not oocyte regeneration occurs in adult life has been the subject of much debate. In this study, we have traced germ-cell lineages over the life…”
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Generation of an all-exon Esr2 deleted mouse line: Effects on fertility by Antonson, Per, Apolinário, Leticia Montanholi, Shamekh, Mohamed M., Humire, Patricia, Poutanen, Matti, Ohlsson, Claes, Nalvarte, Ivan, Gustafsson, Jan-Åke

“…Estrogen receptor beta (ERβ), encoded by the Esr2 gene, is one of two nuclear receptors that mediate the functions of the steroid hormone estradiol. The…”
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ERα expression in T lymphocytes is dispensable for estrogenic effects in bone by Gustafsson, K L, Nilsson, K H, Farman, H H, Andersson, A, Lionikaite, V, Henning, P, Wu, J, Windahl, S H, Islander, U, Movérare-Skrtic, S, Sjögren, K, Carlsten, H, Gustafsson, J-Å, Ohlsson, C, Lagerquist, M K

“…Estrogen treatment has positive effects on the skeleton, and we have shown that estrogen receptor alpha (ERα) expression in cells of hematopoietic origin…”
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Estrogen receptor-beta is the predominant estrogen receptor subtype in human oral epithelium and salivary glands by Valimaa, H, Savolainen, S, Soukka, T, Silvoniemi, P, Makela, S, Kujari, H, Gustafsson, JA, Laine, M

“…Many studies have shown that the oral mucosa and salivary glands are sensitive to estrogen action. However, the expression of estrogen receptors (ERs) within…”
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Oestrogen receptor α gene expression levels are reduced in obese compared to normal weight females by Nilsson, M, Dahlman, I, Ryden, M, Nordstrom, E.A, Gustafsson, J.A, Arner, P, Dahlman-Wright, K

“…Objective: To determine whether oestrogen receptor (ER)alpha messenger RNA (mRNA) levels or single nucleotide polymorphisms (SNPs) are associated with obesity…”
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