In vitro antitumor effects of aqueous extract and protease inhibitors from Sterculia striata st. Hil. et naud and metabolite profiling

In vitro antitumor effects of aqueous extract and protease inhibitors from Sterculia striata st. Hil. et naud and metabolite profiling

The present study aims to assess the cytotoxic effect of the aqueous and protease inhibitors extracts of on breast cancer cell lines. The results showed significant reductions in the highest concentrations from the seed extract for all cell lines. The aqueous extract reduced the viability by up to 3...

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Bibliographic Details
Published in:Natural product research pp. 1 - 6
Main Authors: Junior, Tadeu F Braga, Lima, Nerilson M, Carli, Gabriela P, M Cachuba, Roberta, J Guarneire, Gracimério, J Tabai, Beatriz, M Abrão, Roberta, G Barbosa, Samuel, Machado, Lucas S, S Nunes, Jander, S Machado, Fabiana, Andrade, Teresinha de Jesus A S, Br Castro, Sandra, Vaz, Boniek G, A Amaral, Ernani, S Alves, Caio Cesar, Carli, Alessandra P
Format: Journal Article
Language:English
Published: England 06-02-2024
Subjects:
breast cancer
Sterculia striata
bioactive metabolites
cytotoxicity
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Summary:The present study aims to assess the cytotoxic effect of the aqueous and protease inhibitors extracts of on breast cancer cell lines. The results showed significant reductions in the highest concentrations from the seed extract for all cell lines. The aqueous extract reduced the viability by up to 35% in the MCF-7, 25% in the 4T1, and 35% in the MDA-MB-231 cell lines. Regarding the protease inhibitor extract, a 50% reduction in cell viability was observed in the MDA-MB-231 at concentration of 333 µg/mL. The aqueous and the protease inhibitor extracts showed mild reduction in the viability of macrophage cell lines. Chemical characterisation analysis revealed several polyphenols such as flavonoids, tannins, phenolic acids, and other secondary metabolites including terpenes, steroids, fatty acids, and organic acids, which may be related to the promising bioactivity observed. The showed antitumor activity, emphasising its pharmacological potential.
ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2024.2302326