Search Results - "J P Segrest"

The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function by Segrest, JP, Jones, MK, De Loof, H, Brouillette, CG, Venkatachalapathi, YV, Anantharamaiah, GM

“…Site-directed mutagenesis and other molecular biology-based techniques are now available for probing the amphipathic alpha helix structural motif in the…”
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Effects of increasing hydrophobicity on the physical-chemical and biological properties of a class A amphipathic helical peptide by Datta, G, Chaddha, M, Hama, S, Navab, M, Fogelman, A M, Garber, D W, Mishra, V K, Epand, R M, Epand, R F, Lund-Katz, S, Phillips, M C, Segrest, J P, Anantharamaiah, G M

“…We have recently shown that a class A amphipathic peptide 5F with increased amphipathicity protected mice from diet-induced atherosclerosis (Garber et al. J…”
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A new synthetic class A amphipathic peptide analogue protects mice from diet-induced atherosclerosis by Garber, D W, Datta, G, Chaddha, M, Palgunachari, M N, Hama, S Y, Navab, M, Fogelman, A M, Segrest, J P, Anantharamaiah, G M

“…Several synthetic class A peptide analogues have been shown to mimic many of the properties of human apo A-I in vitro. A new peptide…”
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Interactions of synthetic peptide analogs of the class A amphipathic helix with lipids. Evidence for the snorkel hypothesis by MISHRA, V. K, PALGUNACHARI, M. N, SEGREST, J. P, ANANTHARAMAIAH, G. M

“…Class A amphipathic helixes present in exchangeable plasma apolipoproteins are characterized by the location of positively charged amino acid residues at the…”
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Increased Prevalence of Smaller and Denser LDL Particles in Asian Indians by Kulkarni, Krishnaji R, Markovitz, Jerome H, Nanda, Navin C, Segrest, Jere P

“…There is increasing evidence to believe that Asian Indians are at an increased risk of coronary heart disease (CHD), which cannot be attributed to the common…”
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Only the Two End Helixes of Eight Tandem Amphipathic Helical Domains of Human Apo A-I Have Significant Lipid Affinity: Implications for HDL Assembly by Palgunachari, Mayakonda N, Mishra, Vinod K, Lund-Katz, Sissel, Phillips, Michael C, Adeyeye, Samuel O, Alluri, Sridevi, Anantharamaiah, G.M, Segrest, Jere P

“…Human apolipoprotein A-I (apo A-I) possesses multiple tandem repeating 22-mer amphipathic alpha-helixes. Computer analysis and studies of model synthetic…”
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Quantification of cholesterol in all lipoprotein classes by the VAP-II method by Kulkarni, K.R, Garber, D.W, Marcovina, S.M, Segrest, J.P

“…We have developed a high resolution microvolume Vertical Auto Profile (VAP) method for the simultaneous measurement of cholesterol in all lipoprotein classes,…”
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ApoB-100 has a pentapartite structure composed of three amphipathic α-helical domains alternating with two amphipathic β-strand domains : detection by the computer program LOCATE by SEGREST, J. P, JONES, M. K, MISHRA, V. K, ANANTHARAMAIAH, G. M, GARBER, D. W

“…Due to the great length of apolipoprotein (apo) B-100, the localization of lipid-associating domains in this protein has been difficult. To address this…”
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Osmotically Induced Membrane Tension Modulates Membrane Permeabilization by Class L Amphipathic Helical Peptides: Nucleation Model of Defect Formation by Polozov, I.V., Anantharamaiah, G.M., Segrest, J.P., Epand, R.M.

“…The mechanism of action of lytic peptides on membranes is widely studied and is important in view of potential medical applications. Previously (I. V. Polozov,…”
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Amphipathic helix motif: classes and properties by Segrest, J P, De Loof, H, Dohlman, J G, Brouillette, C G, Anantharamaiah, G M

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Role of Lipids in the Permeabilization of Membranes by Class L Amphipathic Helical Peptides by Polozov, I. V, Polozova, A. I, Tytler, E. M, Anantharamaiah, G. M, Segrest, J. P, Woolley, G. A, Epand, R. M

“…We studied the mechanism of membrane permeabilization by the 18L model peptide (GIKKFLGSIWKFIKAFVG), which features the consensus class L sequence averaged…”
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Reciprocal effects of apolipoprotein and lytic peptide analogs on membranes. Cross-sectional molecular shapes of amphipathic alpha helixes control membrane stability by Tytler, E M, Segrest, J P, Epand, R M, Nie, S Q, Epand, R F, Mishra, V K, Venkatachalapathi, Y V, Anantharamaiah, G M

“…Apolipoprotein (class A) amphipathic helixes are postulated to act as detergents by virtue of their cross-section being wedge-shaped. Using computer analysis…”
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Cytosolic domain of the human immunodeficiency virus envelope glycoproteins binds to calmodulin and inhibits calmodulin-regulated proteins by Srinivas, S.K., Srinivas, R.V., Anantharamaiah, G.M., Compans, R.W., Segrest, J.P.

“…Calmodulin (CaM), the major intracellular receptor for calcium, is involved in regulation of diverse cellular functions. Positively charged amphipathic helical…”
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Computer programs to identify and classify amphipathic alpha helical domains by Jones, MK, Anantharamaiah, GM, Segrest, JP

“…The amphipathic alpha helix is an often-encountered secondary structural motif in biologically active peptides and proteins. An amphipathic helix is defined as…”
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Structure of apolipoprotein B-100 in low density lipoproteins by Segrest, J P, Jones, M K, De Loof, H, Dashti, N

“…There is general consensus that amphipathic alpha-helices and beta sheets represent the major lipid-associating motifs of apolipoprotein (apo)B-100. In this…”
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Potencies of Lipoproteins in Fasting and Postprandial Plasma to Accept Additional Cholesterol Molecules Released From Cell Membranes by Chung, Byung Hong, Franklin, Frank, Cho, B.H. Simon, Segrest, J.P, Hart, Karen, Darnell, Betty E

“…To investigate the role of various lipoproteins in plasma to promote cholesterol efflux from cell membranes, potencies of lipoproteins in normolipidemic…”
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Binding of apolipoprotein A-I model peptides to lipid bilayers. Measurement of binding isotherms and peptide-lipid headgroup interactions by Spuhler, P, Anantharamaiah, G M, Segrest, J P, Seelig, J

“…Amphiphatic alpha-helices are the lipid-binding motif in many apolipoproteins. Two model peptides, namely…”
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Identification and cholesterol quantification of low density lipoprotein subclasses in young adults by VAP-II methodology by Kulkarni, K.R. (University of Alabama at Birmingham, Birmingham, AL.), Garber, D.W, Jones, M.K, Segrest, J.P

“…Low density lipoprotein (LDL) particles are heterogeneous in size, density, and chemical composition; small, dense LDL may be more atherogenic than large,…”
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In vitro production of β-very low density lipoproteins and small, dense low density lipoproteins in mildly hypertriglyceridemic plasma: role of activities of lecithin:cholester acyltransferase, cholesterylester transfer proteins and lipoprotein lipase by Hong Chung, Byung, Segrest, Jere P, Franklin, Frank

“…As a model for the formation of β-very low density lipoproteins (VLDL) and small, dense LDL by the intraplasma metabolic activities in vivo, lipoproteins in…”
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Apolipoprotein A-I decreases neutrophil degranulation and superoxide production by Blackburn, WD, Dohlman, JG, Venkatachalapathi, YV, Pillion, DJ, Koopman, WJ, Segrest, JP, Anantharamaiah, GM

“…Neutrophils participate in the acute phase response and are often associated with tissue injury in a number of inflammatory disorders. The acute phase response…”
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