Search Results - "J M Essigmann"

Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens by Fox, J G, Feng, Y, Theve, E J, Raczynski, A R, Fiala, J L A, Doernte, A L, Williams, M, McFaline, J L, Essigmann, J M, Schauer, D B, Tannenbaum, S R, Dedon, P C, Weinman, S A, Lemon, S M, Fry, R C, Rogers, A B

“…Hepatocellular carcinoma (HCC) frequently results from synergism between chemical and infectious liver carcinogens. Worldwide, the highest incidence of HCC is…”
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Chemical biology of mutagenesis and DNA repair: cellular responses to DNA alkylation by Shrivastav, Nidhi, Li, Deyu, Essigmann, John M.

“…The reaction of DNA-damaging agents with the genome results in a plethora of lesions, commonly referred to as adducts. Adducts may cause DNA to mutate, they…”
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Design, synthesis, and evaluation of estradiol-linked genotoxicants as anti-cancer agents by SHARMA, U, MARQUIS, J. C, DINAUT, A. Nicole, HILLIER, S. M, FEDELES, B, RYE, P. T, ESSIGMANN, J. M, CROY, R. G

“…A series of bifunctional compounds was prepared consisting of 17beta estradiol linked to a DNA damaging N,N-bis-(2-chloroethyl)aniline. The objective of our…”
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Isolation and Characterization of Human cDNA Clones Encoding a High Mobility Group Box Protein that Recognizes Structural Distortions to DNA Caused by Binding of the Anticancer Agent Cisplatin by Bruhn, Suzanne L., Pil, Pieter M., Essigmann, John M., Housman, David E., Lippard, Stephen J.

“…Human cDNA clones encoding a structure-specific recognition protein, SSRP1, that binds specifically to DNA modified with cisplatin have been isolated and…”
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Mechanistic studies of ionizing radiation and oxidative mutagenesis: genetic effects of a single 8-hydroxyguanine (7-hydro-8-oxoguanine) residue inserted at a unique site in a viral genome by Wood, Michael L, Dizdaroglu, Miral, Gajewski, Ewa, Essigmann, John M

“…T4 RNA ligase was used to construct a deoxypentanucleotide containing a single 8-hydroxyguanine (7-hydro-8-oxoguanine; G8-OH) residue, which is one of the…”
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X-Ray Structure of a DNA Decamer Containing 7,8-Dihydro-8-Oxoguanine by Lipscomb, Leigh Ann, Peek, Mary Elizabeth, Morningstar, Marshall L., Verghis, Susan M., Miller, Elizabeth M., Rich, Alexander, Essigmann, John M., Williams, Loren Dean

“…We have determined the x-ray structure of a DNA fragment containing 7,8-dihydro-8-oxoguanine (GO). The structure of the duplex form of d(CCAGOCGCTGG) has been…”
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Site-specific mutagenesis: retrospective and prospective by Singer, B, Essigmann, J M

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Substrate specificity of ultraviolet DNA endonuclease (UVDE/Uve1p) from Schizosaccharomyces pombe by Avery, A.M, Kaur, B, Taylor, J.S, Mello, J.A, Essigmann, J.M, Doetsch, P.W

“…Schizosaccharomyces pombe ultraviolet DNA endonuclease (UVDE or Uve1p) has been shown to cleave 5′ to UV light-induced cyclobutane pyrimidine dimers (CPDs) and…”
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Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein by McGoldrick, John P., Yeh, Yang-Chen, Solomon, Marjorie, Essigmann, John M., Lu, A-Lien

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Human Endonuclease III Acts Preferentially on DNA Damage Opposite Guanine Residues in DNA by Eide, Lars, Luna, Luisa, Gustad, Ellen C, Henderson, Paul T, Essigmann, John M, Demple, Bruce, Seeberg, Erling

“…The human endonuclease III homologue (hNTH1) removes premutagenic cytosine damage from DNA. This includes 5-hydroxycytosine, which has increased potential for…”
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Genetic Effects of Thymine Glycol: Site-Specific Mutagenesis and Molecular Modeling Studies by Basu, Ashis K., Loechler, Edward L., Leadon, Steven A., Essigmann, John M.

“…The mutational specificity and genetic requirements for mutagenesis by 5,6-dihydroxy-5,6-dihydrothymine (thymine glycoI), one of the principal DNA lesions…”
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Cisplatin-DNA Adducts are Molecular Decoys for the Ribosomal RNA Transcription Factor hUBF (Human Upstream Binding Factor) by Treiber, Daniel K., Zhai, Xiaoquan, Jantzen, Hans-Michael, Essigmann, John M.

“…The toxicity of DNA-damaging agents is widely believed to result from the formation of lesions that block polymerases or disrupt the integrity of the genome. A…”
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Genetic effects of oxidative DNA damage: comparative mutagenesis of 7,8-dihydro-8-oxoguanine and 7,8-dihydro-8-oxoadenine in Escherichia coli by Wood, Michael L., Esteve, Asuncion, Morningstar, Marshall L., Kuziemko, Geoffrey M., Essigmann, John M.

“…A single 7,8-dihydro-8-oxoguanine (G8-oxo; 8-hydroxy-guanine) adduct in the lacZα gene of bacteriophage M13 DNA induces a targeted G—T transversion after…”
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An Intrastrand d(GpG) Platinum Crosslink in Duplex M13 DNA is Refractory to Repair by Human Cell Extracts by Szymkowski, David E., Yarema, Kevin, Essigmann, John M., Lippard, Stephen J., Wood, Richard D.

“…We have examined the ability of human cell extracts to repair the most frequent DNA adduct caused by the cancer chemotherapeutic agent…”
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Mass spectral identification and positional mapping of aflatoxin B1-Guanine adducts in oligonucleotides by MARZILLI, L. A, WANG, D, KOBERTZ, W. R, ESSIGMANN, J. M, VOUROS, P

“…The biological consequences of a carcinogen-DNA adduct are defined by the structure of the lesion and its position within the genome. Electrospray ionization…”
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Characterization of a DNA damage-recognition protein from mammalian cells that binds specifically to intrastrand d(GpG) and d(ApG) DNA adducts of the anticancer drug cisplatin by Donahue, Brian A, Augot, Marianne, Bellon, Steven F, Treiber, Daniel K, Toney, Jeffrey H, Lippard, Stephen J, Essigmann, John M

“…A factor has been identified in extracts from human HeLa and hamster V79 cells that retards the electrophoretic mobility of several DNA restriction fragments…”
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Replication inhibition and translesion synthesis on templates containing site- specifically placed cis-diamminedichloroplatinum(II) DNA adducts by Comess, Kenneth M, Burstyn, Judith N, Essigmann, John M, Lippard, Stephen J

“…A series of site-specifically plantinated, covalently closed circular M13 genomes (7250 bp) was constructed in order to evaluate the consequences of DNA…”
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Relative efficiencies of the bacterial, yeast, and human DNA methyltransferases for the repair of O6-methylguanine and O4-methylthymine. Suggestive evidence for O4-methylthymine repair by eukaryotic methyltransferases by Sassanfar, M, Dosanjh, M K, Essigmann, J M, Samson, L

“…The suicidal inactivation mechanism of DNA repair methyltransferases (MTases) was exploited to measure the relative efficiencies with which the Escherichia…”
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Effect of sequence context on O(6)-methylguanine repair and replication in vivo by Delaney, J C, Essigmann, J M

“…Understanding the origins of mutational hotspots is complicated by the intertwining of several variables. The selective formation, repair, and replication of a…”
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Repair of an Interstrand DNA Cross-link Initiated by ERCC1-XPF Repair/Recombination Nuclease by Kuraoka, I, Kobertz, W R, Ariza, R R, Biggerstaff, M, Essigmann, J M, Wood, R D

“…Interstrand DNA cross-link damage is a severe challenge to genomic integrity. Nucleotide excision repair plays some role in the repair of DNA cross-links…”
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