Search Results - "J M Besterman"

Activity of MGCD290, a Hos2 Histone Deacetylase Inhibitor, in Combination with Azole Antifungals against Opportunistic Fungal Pathogens by Pfaller, M.A, Messer, S.A, Georgopapadakou, N, Martell, L.A, Besterman, J.M, Diekema, D.J

“…We report on the in vitro activity of the Hos2 fungal histone deacetylase (HDAC) inhibitor MGCD290 (MethylGene, Inc.) in combination with azoles against…”
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A phase I pharmacokinetic and pharmacodynamic study of the DNA methyltransferase 1 inhibitor MG98 administered twice weekly by Stewart, D. J., Donehower, R. C., Eisenhauer, E. A., Wainman, N., Shah, A. K., Bonfils, C., MacLeod, A. R., Besterman, J. M., Reid, G. K.

“…Background: Hypermethylation and inactivation of tumor suppressor genes by the enzyme DNA methyltransferase may lead to neoplastic transformation. MG98, a…”
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Models of Human Metastatic Colon Cancer in Nude Mice Orthotopically Constructed by Using Histologically Intact Patient Specimens by Fu, Xinyu, Besterman, Jeffrey M., Monosov, Ann, Hoffman, Robert M.

“…There is an important need for clinically relevant animal models for human cancers. Toward this goal, histologically intact human colon-cancer specimens…”
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Rapid Formation of Diacylglycerol from Phosphatidylcholine: A Pathway for Generation of a Second Messenger by Besterman, Jeffrey M., Duronio, Vincent, Cuatrecasas, Pedro

“…The classic pathway for agonist-induced generation of diacylglycerol is via activation of a phospholipase C-mediated hydrolysis of the ``phosphoinositides.''…”
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Elevation of topoisomerase I messenger RNA, protein, and catalytic activity in human tumors : demonstration of tumor-type specificity and implications for cancer chemotherapy by INTISAR HUSAIN, MOHLER, J. L, SEIGLER, H. F, BESTERMAN, J. M

“…Topoisomerase I has been identified as an intracellular target of camptothecin, a plant alkaloid with anticancer activity. Various lines of evidence suggest…”
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Mammalian DNA ligase III: molecular cloning, chromosomal localization, and expression in spermatocytes undergoing meiotic recombination by Chen, Jingwen, Tomkinson, Alan E., Ramos, William, Mackey, Zachary B., Danehower, Sue, Walter, Christi A., Schultz, Roger A., Besterman, Jeffrey M., Husain, Intisar

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I by Luzzio, Michael J, Besterman, Jeffrey M, Emerson, David L, Evans, Michael G, Lackey, Karen, Leitner, Peter L, McIntyre, Gordon, Morton, Bradley, Myers, Peter L, Peel, Michael, Sisco, Jay M, Sternbach, Daniel D, Tong, Wei-Qin, Truesdale, Ann, Uehling, David E, Vuong, Alan, Yates, Julie

“…The synthesis and antitumor activities of the novel water soluble camptothecin derivatives 7-[(4-methylpiperazino)methyl]-10,11-(methylenedioxy)-(20S)-campto…”
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Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange by J M Besterman, W S May, Jr, H LeVine, 3rd, E J Cragoe, Jr, P Cuatrecasas

“…The human leukemic cell line, HL-60, differentiates in response to tumor-promoting phorbol esters. Recently, we have reported that one of the first events…”
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Collagen cross-link metabolites in urine as markers of bone metastases in prostatic carcinoma by Miyamoto, K K, McSherry, S A, Robins, S P, Besterman, J M, Mohler, J L

“…The efficacy of radionuclide bone scans in monitoring metastatic bone activity remains controversial. Objective measurement of bone tumor burden would be…”
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Phorbol Esters Rapidly Stimulate Amiloride-Sensitive Na+/ H+ Exchange in a Human Leukemic Cell Line by Besterman, Jeffrey M., Cuatrecasas, Pedro

“…The human, leukemic cell line, HL-60, undergoes differentiation in response to tumor-promoting phorbol esters. Recent studies have implicated stimulation of a…”
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Inhibition of DNA helicase II unwinding and ATPase activities by DNA-interacting ligands. Kinetics and specificity by GEORGE, J. W, GHATE, S, MATSON, S. W, BESTERMAN, J. M

“…Although DNA helicases play important roles in the processing of DNA, little is known about the effects of DNA-interacting ligands on these helicases…”
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Endocytosis: a review of mechanisms and plasma membrane dynamics by Besterman, J M, Low, R B

“…The purpose of this review is to summarize recent findings relating to mechanisms of both phagocytosis and pinocytosis. With regard to phagocytosis, the…”
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Mammalian DNA ligase II is highly homologous with vaccinia DNA ligase. Identification of the DNA ligase II active site for enzyme-adenylate formation by Wang, Y.C., Burkhart, W.A., Mackey, Z.B., Moyer, M.B., Ramos, W, Husain, I, Chen, J, Besterman, J.M., Tomkinson, A.E.

“…Mammalian cells contain three biochemically distinct DNA ligases. In this report we describe the purification of DNA ligase II to homogeneity from bovine liver…”
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Diacylglycerol-Induced Translocation of Diacylglycerol Kinase: Use of Affinity-Purified Enzyme in a Reconstitution System by Besterman, Jeffrey M., Pollenz, Richard S., Booker, Elijah L., Cuatrecasas, Pedro

“…Diacylglycerol-induced translocation of diacylglycerol kinase (ATP:1,2-diacylglycerol 3-phosphotransferase, EC 2.7.1.107) from the soluble to the…”
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Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts by Besterman, J M, Watson, S P, Cuatrecasas, P

“…The hypothesis that inositol phospholipid degradation is a step in the mechanism by which epidermal growth factor (EGF) stimulates mitogenesis in confluent…”
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Rigid Analogs of Camptothecin as DNA Topoisomerase I Inhibitors by Lackey, Karen, Besterman, Jeffrey M, Fletcher, Wade, Leitner, Peter, Morton, Bradley, Sternbach, Daniel D

“…Substituted 8-ethyl-2-(2-oxo-1,2-dihydroindol-3-ylidene)-8-hydroxy-2,3,5,8- tetrahydro-6-oxa-3a-azacyclopenta[b]naphthalene-1,4,7-triones were synthesized and…”
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Water Soluble Inhibitors of Topoisomerase I:  Quaternary Salt Derivatives of Camptothecin by Lackey, Karen, Sternbach, Daniel D, Croom, Dallas K, Emerson, David L, Evans, Michael G, Leitner, Peter L, Luzzio, Michael J, McIntyre, Gordon, Vuong, Alain, Yates, Julie, Besterman, Jeffrey M

“…Eleven water soluble 7-substituted quaternary ammonium salt derivatives of 10,11-(methylenedioxy)- and 10,11-(ethylenedioxy)-(20S)-camptothecin were…”
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Amiloride intercalates into DNA and inhibits DNA topoisomerase II by Besterman, J M, Elwell, L P, Blanchard, S G, Cory, M

“…Amiloride is capable of inhibiting DNA synthesis in mammalian cells in culture. Recent evidence indicates that the enzyme, DNA topoisomerase II, is probably…”
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Down-regulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms by Fournel, M, Sapieha, P, Beaulieu, N, Besterman, J M, MacLeod, A R

“…A common event in the development of human neoplasia is the loss of growth regulatory tumor suppressor functions. Methylation of 5' CpG islands of tumor…”
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Inhibition of Epidermal Growth Factor-Induced Mitogenesis by Amiloride and an Analog: Evidence against a Requirement for Na+/H+Exchange by Besterman, Jeffrey M., Tyrey, Scott J., Cragoe, Edward J., Cuatrecasas, Pedro

“…We have tested the hypothesis that the rapid stimulation of Na+/H+exchange by epidermal growth factor (EGF) is a requirement for induction of mitogenesis…”
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