Search Results - "J D Groopman"

Protective alterations in phase 1 and 2 metabolism of aflatoxin B1 by oltipraz in Residents of Qidong, People's Republic of China by WANG, J.-S, XINNAN SHEN, JACOBSON, L. P, MUNOZ, A, HELZLSOUER, K. J, GROOPMAN, J. D, KENSLER, T. W, XIA HE, ZHU, Y.-R, ZHANG, B.-C, WANG, J.-B, QIAN, G.-S, KUANG, S.-Y, ZARBA, A, EGNER, P. A

“…Residents of Qidong, People's Republic of China, are at high risk for development of hepatocellular carcinoma, in part due to consumption of foods contaminated…”
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Maternal serum proteome changes between the first and third trimester of pregnancy in rural Southern Nepal by Scholl, P.F, Cole, R.N, Ruczinski, I, Gucek, M, Diez, R, Rennie, A, Nathasingh, C, Schulze, K, Christian, P, Yager, J.D, Groopman, J.D, West, K.P

“…Abstract Characterization of normal changes in the serum proteome during pregnancy may enhance understanding of maternal physiology and lead to the development…”
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Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology by Kensler, Thomas W, Roebuck, Bill D, Wogan, Gerald N, Groopman, John D

“…Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous contaminants of the human food supply throughout the economically…”
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Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma by Ross, R K, Yuan, J M, Yu, M C, Wogan, G N, Qian, G S, Tu, J T, Groopman, J D, Gao, Y T, Henderson, B E

“…Aflatoxins have long been suspected to be human hepatic carcinogens but no direct study was feasible until assays to measure individual aflatoxin exposure…”
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Genetic alterations in hepatocellular carcinomas : association between loss of chromosome 4q and p53 gene mutations by RASHID, A, WANG, J.-S, QIAN, G.-S, LU, B.-X. SR, HAMILTON, S. R, GROOPMAN, J. D

“…The major risk factors for hepatocellular carcinomas (HCC) in high incidence areas include infection with hepatitis B and C viruses (HBV, HCV) and exposure to…”
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Simian Virus 40 Large Tumor Antigen-Immortalized Normal Human Liver Epithelial Cells Express Hepatocyte Characteristics and Metabolize Chemical Carcinogens by Andrea M. A. Pfeifer, Cole, Katherine E., Smoot, Duane T., Weston, Ainsley, Groopman, John D., Shields, Peter G., Vignaud, Jean-Michel, Juillerat, Michel, Lipsky, Michael M., Trump, Benjamin F., Lechner, John F., Harris, Curtis C.

“…Normal human liver tissue and cultured human hepatocytes are valuable models to study xenobiotic metabolism and toxicity, but they only have a limited in vitro…”
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Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A by Kinirons, Mark T., O'Shea, Diarmuid, Kim, Richard B., Groopman, John D., Thummel, Kenneth E., Wood, Alastair J. J., Wilkinson, Grant R.

“…Background Cytochrome P4503A (CYP3A) activity exhibits considerable interindividual variability, and an in vivo probe to measure such differences would serve…”
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High prevalence of non-alcoholic fatty liver disease and metabolic risk factors in Guatemala: A population-based study by Rivera-Andrade, A., Kroker-Lobos, M.F., Lazo, M., Freedman, N.D., Smith, J.W., Torres, O., McGlynn, K.A., Groopman, J.D., Guallar, E., Ramirez-Zea, M.

“…There are no data on the prevalence of non-alcoholic fatty liver disease (NAFLD) in general population samples in Guatemala or in other Central American…”
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Interindividual differences in the concentration of 1-hydroxypyrene-glucuronide in urine and polycyclic aromatic hydrocarbon-DNA adducts in peripheral white blood cells after charbroiled beef consumption by Kang, D H, Rothman, N, Poirier, M C, Greenberg, A, Hsu, C H, Schwartz, B S, Baser, M E, Groopman, J D, Weston, A, Strickland, P T

“…Biological markers of internal dose and macromolecular dose from PAHs provide a potential means of assessing environmental exposure to PAHs through inhalation,…”
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Lack of Specificity of trans,trans-Muconic Acid as a Benzene Biomarker after Ingestion of Sorbic Acid-preserved Foods by WEAVER, V. M, BUCKLEY, T, GROOPMAN, J. D

“…The benzene metabolite, trans,trans -muconic acid (MA), has been shown to be a sensitive and specific biomarker for ambient benzene exposure levels as low as…”
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Liquid Chromatography Electrospray-Mass Spectrometry of Urinary Aflatoxin Biomarkers:  Characterization and Application to Dosimetry and Chemoprevention in Rats by Walton, Michael, Egner, Patricia, Scholl, Peter F, Walker, Jewell, Kensler, Thomas W, Groopman, John D

“…A liquid chromatography electrospray tandem mass spectrometry (LC-ESI-MS/MS) method for the measurement of aflatoxin biomarkers in urine has been developed and…”
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Genotyping by mass spectrometric analysis of short DNA fragments by Vogelstein, Bert, Laken, Steven J, Jackson, Peta E, Kinzler, Kenneth W, Strickland, Paul T, Groopman, John D, Friesen, Marlin D

“…A method has been developed to produce small DNA fragments from PCR products for analysis of defined DNA variations by mass spectrometry. The genomic region to…”
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Downregulation of DNA excision repair by the hepatitis B virus-x protein occurs in p53-proficient and p53-deficient cells by Groisman, Iris Jaitovich, Koshy, Rajen, Henkler, Frank, Groopman, John D., Alaoui-Jamali, Moulay A.

“…Synergism between exposure to chemical carcinogens and infection with the hepatitis B virus (HBV) has been implicated in the high incidence of hepatocellular…”
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An automated, handheld biosensor for aflatoxin by Carlson, M.A., Bargeron, C.B., Benson, R.C., Fraser, A.B., Phillips, T.E., Velky, J.T., Groopman, J.D., Strickland, P.T., Ko, H.W.

“…A new immunoaffinity fluorometric biosensor has been developed for detecting and quantifying aflatoxins, a family of potent fungi-produced carcinogens that are…”
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Temporal acquisition of sequential mutations in the enhancer II and basal core promoter of HBV in individuals at high risk for hepatocellular carcinoma by XIN BAI, YU ZHU, HONG TU, YAN JIN, XIA GUO, GENGSUN QIAN, TAOYANG CHEN, JING ZHANG, JINBING WANG, GROOPMAN, John D, JIANREN GU

“…To investigate the roles of mutations in enhancer II (Enh II) and basal core promoter (BCP) of hepatitis B virus (HBV) in hepatocellular carcinoma (HCC), we…”
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Oltipraz chemoprevention trial in Qidong, People's Republic of China: study design and clinical outcomes by L P Jacobson, B C Zhang, Y R Zhu, J B Wang, Y Wu, Q N Zhang, L Y Yu, G S Qian, S Y Kuang, Y F Li, X Fang, A Zarba, B Chen, C Enger, N E Davidson, M B Gorman, G B Gordon, H J Prochaska, P A Egner, J D Groopman, A Muñoz, K J Helzlsouer, T W Kensler

“…In 1995, 234 adults from Qidong, Jiangsu Province, People's Republic of China, where hepatocellular carcinoma is the leading cause of cancer deaths and…”
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SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity by Herman, James G, Yoshikawa, Hirohide, Matsubara, Kenichi, Qian, Geng-Sun, Jackson, Peta, Groopman, John D, Manning, Jasper E, Harris, Curtis C

“…Hepatocellular carcinoma (HCC) is a major cause of cancer death, but the molecular mechanism for its development beyond its initiation has not been well…”
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Molecular epidemiology of aflatoxin exposures: validation of aflatoxin-N7-guanine levels in urine as a biomarker in experimental rat models and humans by Groopman, J.D, Wild, C.P, Hasler, J, Junshi, C, Wogan, G.N, Kensler, T.W

“…Human epidemiology and experimental animal data have provided the statistical association and biological information necessary to propose that aflatoxins are…”
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Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in guangxi autonomous region, people's republic in China by GROOPMAN, J. D, ZHU JIAQI, DONAHUE, P. R.K, PIKUL, A, LISHENG, Z, JUN-SHI, C, WOGAN, G. N

“…Hepatocellular carcinoma is one of the five leading human cancers causing at least 250,000 deaths each year. One of the major risk factors for this disease is…”
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Role of metabolism and viruses in aflatoxin-induced liver cancer by Groopman, John D., Kensler, Thomas W.

“…The use of biomarkers in molecular epidemiology studies for identifying stages in the progression of development of the health effects of environmental agents…”
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