Search Results - "J Connell"

Prevalence and correlates of diagnosed and undiagnosed type 2 diabetes mellitus and pre-diabetes in older adults: Findings from the Irish Longitudinal Study on Ageing (TILDA) by Leahy, S, O’ Halloran, A.M, O’ Leary, N, Healy, M, McCormack, M, Kenny, R.A, O’ Connell, J

“…Highlights • We validate HbA1c measurement from frozen buffy coat samples. • We investigate prevalence of type 2 diabetes and pre-diabetes in older Irish…”
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Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function by Grevendonk, L., Connell, N. J., McCrum, C., Fealy, C. E., Bilet, L., Bruls, Y. M. H., Mevenkamp, J., Schrauwen-Hinderling, V. B., Jörgensen, J. A., Moonen-Kornips, E., Schaart, G., Havekes, B., de Vogel-van den Bosch, J., Bragt, M. C. E., Meijer, K., Schrauwen, P., Hoeks, J.

“…The relationship between the age-associated decline in mitochondrial function and its effect on skeletal muscle physiology and function remain unclear. In the…”
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Ion torrent high throughput mitochondrial genome sequencing (HTMGS) by Harvey, N R, Albury, C L, Stuart, S, Benton, M C, Eccles, D A, Connell, J R, Sutherland, H G, Allcock, R J N, Lea, R A, Haupt, L M, Griffiths, L R

“…The implementation and popularity of next generation sequencing (NGS) has led to the development of various rapid whole mitochondrial genome sequencing…”
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Circadian misalignment induces fatty acid metabolism gene profiles and compromises insulin sensitivity in human skeletal muscle by Wefers, Jakob, van Moorsel, Dirk, Hansen, Jan, Connell, Niels J., Havekes, Bas, Hoeks, Joris, van Marken Lichtenbelt, Wouter D., Duez, Hélène, Phielix, Esther, Kalsbeek, Andries, Boekschoten, Mark V., Hooiveld, Guido J., Hesselink, Matthijs K. C., Kersten, Sander, Staels, Bart, Scheer, Frank A. J. L., Schrauwen, Patrick

“…Circadian misalignment, such as in shift work, has been associated with obesity and type 2 diabetes. However, direct effects of circadian misalignment on…”
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Nurse Expertise: A Critical Resource in the COVID-19 Pandemic Response by Nayna Schwerdtle, Patricia, Connell, Clifford J, Lee, Susan, Plummer, Virginia, Russo, Philip L, Endacott, Ruth, Kuhn, Lisa

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Proof of principle for epitope-focused vaccine design by Correia, Bruno E., Bates, John T., Loomis, Rebecca J., Baneyx, Gretchen, Carrico, Chris, Jardine, Joseph G., Rupert, Peter, Correnti, Colin, Kalyuzhniy, Oleksandr, Vittal, Vinayak, Connell, Mary J., Stevens, Eric, Schroeter, Alexandria, Chen, Man, MacPherson, Skye, Serra, Andreia M., Adachi, Yumiko, Holmes, Margaret A., Li, Yuxing, Klevit, Rachel E., Graham, Barney S., Wyatt, Richard T., Baker, David, Strong, Roland K., Crowe, James E., Johnson, Philip R., Schief, William R.

“…Vaccines prevent infectious disease largely by inducing protective neutralizing antibodies against vulnerable epitopes. Several major pathogens have resisted…”
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Preparation of atomically flat SrTiO3 surfaces using a deionized-water leaching and thermal annealing procedure by Connell, J. G., Isaac, B. J., Ekanayake, G. B., Strachan, D. R., Seo, S. S. A.

“…We report that a deionized water leaching and thermal annealing technique can be effective for preparing atomically flat and singly terminated surfaces of…”
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Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans by Remie, Carlijn ME, Roumans, Kay HM, Moonen, Michiel PB, Connell, Niels J, Havekes, Bas, Mevenkamp, Julian, Lindeboom, Lucas, de Wit, Vera HW, van de Weijer, Tineke, Aarts, Suzanne ABM, Lutgens, Esther, Schomakers, Bauke V, Elfrink, Hyung L, Zapata-Pérez, Rubén, Houtkooper, Riekelt H, Auwerx, Johan, Hoeks, Joris, Schrauwen-Hinderling, Vera B, Phielix, Esther, Schrauwen, Patrick

“…Nicotinamide riboside (NR) is an NAD+ precursor that boosts cellular NAD+ concentrations. Preclinical studies have shown profound metabolic health effects…”
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AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study by Boyle, J. G., Logan, P. J., Jones, G. C., Small, M., Sattar, N., Connell, J. M. C., Cleland, S. J., Salt, I. P.

“…Aims/hypothesis The hypoglycaemic actions of metformin have been proposed to be mediated by hepatic AMP-activated protein kinase (AMPK). As the effects of…”
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Near-Infrared Fluorescence Imaging for Real-Time Intraoperative Anatomical Guidance in Minimally Invasive Surgery: A Systematic Review of the Literature by Schols, Rutger M., Connell, Niels J., Stassen, Laurents P. S.

“…Introduction Near-infrared fluorescence (NIRF) imaging, using contrast agents with fluorescent characteristics in the near-infrared (NIR: 700–900 nm) window,…”
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CCR5 structural plasticity shapes HIV-1 phenotypic properties by Colin, Philippe, Zhou, Zhicheng, Staropoli, Isabelle, Garcia-Perez, Javier, Gasser, Romain, Armani-Tourret, Marie, Benureau, Yann, Gonzalez, Nuria, Jin, Jun, Connell, Bridgette J, Raymond, Stéphanie, Delobel, Pierre, Izopet, Jacques, Lortat-Jacob, Hugues, Alcami, Jose, Arenzana-Seisdedos, Fernando, Brelot, Anne, Lagane, Bernard

“…CCR5 plays immune functions and is the coreceptor for R5 HIV-1 strains. It exists in diverse conformations and oligomerization states. We interrogated the…”
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Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation by Corral, Victor M, Schultz, Eric R, Connell, Gregory J

“…The transferrin receptor (TfR1) is the principal means of iron importation for most mammalian cells, and regulation of mRNA stability is a major mechanism…”
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Initiation of ART during early acute HIV infection preserves mucosal Th17 function and reverses HIV-related immune activation by Schuetz, Alexandra, Deleage, Claire, Sereti, Irini, Rerknimitr, Rungsun, Phanuphak, Nittaya, Phuang-Ngern, Yuwadee, Estes, Jacob D, Sandler, Netanya G, Sukhumvittaya, Suchada, Marovich, Mary, Jongrakthaitae, Surat, Akapirat, Siriwat, Fletscher, James L K, Kroon, Eugene, Dewar, Robin, Trichavaroj, Rapee, Chomchey, Nitiya, Douek, Daniel C, O Connell, Robert J, Ngauy, Viseth, Robb, Merlin L, Phanuphak, Praphan, Michael, Nelson L, Excler, Jean-Louis, Kim, Jerome H, de Souza, Mark S, Ananworanich, Jintanat

“…Mucosal Th17 cells play an important role in maintaining gut epithelium integrity and thus prevent microbial translocation. Chronic HIV infection is…”
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Exercise-Induced Fatigue and Caffeine Supplementation Affect Psychomotor Performance but Not Covert Visuo-Spatial Attention by Connell, Charlotte J W, Thompson, Benjamin, Kuhn, Gustav, Gant, Nicholas

“…Fatigue resulting from strenuous exercise can impair cognition and oculomotor control. These impairments can be prevented by administering psychostimulants…”
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Human immunodeficiency virus and heparan sulfate: from attachment to entry inhibition by Connell, Bridgette J, Lortat-Jacob, Hugues

“…By targeting cells that provide protection against infection, HIV-1 causes acquired immunodeficiency syndrome. Infection starts when gp120, the viral envelope…”
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Pedigree derived mutation rate across the entire mitochondrial genome of the Norfolk Island population by Connell, J. R., Benton, M. C., Lea, R. A., Sutherland, H. G., Chaseling, J., Haupt, L. M., Wright, K. M., Griffiths, L. R.

“…Estimates of mutation rates for various regions of the human mitochondrial genome (mtGenome) vary widely, depending on whether they are inferred using a…”
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Efficacy and safety of the first-in-class imidazoline-2 receptor ligand CR4056 in pain from knee osteoarthritis and disease phenotypes: a randomized, double-blind, placebo-controlled phase 2 trial by Rovati, L.C., Brambilla, N., Blicharski, T., Connell, J., Vitalini, C., Bonazzi, A., Giacovelli, G., Girolami, F., D'Amato, M.

“…CR4056 is a selective imidazoline-2 (I2) receptor ligand with potent analgesic activity in animal pain models. This proof-of-concept study tested CR4056…”
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Characterising the allergic fungal rhinosinusitis microenvironment using full‐length 16S rRNA gene amplicon sequencing and fungal ITS sequencing by Connell, J. T., Bouras, G., Yeo, K., Fenix, K., Cooksley, C., Bassiouni, A., Vreugde, S., Wormald, P. J., Psaltis, A. J.

“…Introduction Allergic fungal rhinosinusitis (AFRS) is a severe phenotype of chronic rhinosinusitis with nasal polyposis (CRSwNP), characterised by localised…”
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Multiple Stressors on Coral Reefs: A Long-Term Perspective by Hughes, T. P., Connell, J. H.

“…Coral reefs are subject to a high frequency of recurrent biological and physical disturbances. The temporal and spatial scales of these are often large and…”
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Caffeine increases the velocity of rapid eye movements in unfatigued humans by Connell, Charlotte J. W., Thompson, Benjamin, Turuwhenua, Jason, Hess, Robert F., Gant, Nicholas

“…Background Caffeine is a widely used dietary stimulant that can reverse the effects of fatigue on cognitive, motor and oculomotor function. However, few…”
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