Search Results - "J Brett, Stephen"

Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention? by Wandrag, Liesl, Brett, Stephen J, Frost, Gary S, Bountziouka, Vasiliki, Hickson, Mary

“…Muscle wasting in the critically ill is up to 2% per day and delays patient recovery and rehabilitation. It is linked to inflammation, organ failure and…”
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Long-term outcomes after critical illness: recent insights by Rousseau, Anne-Françoise, Prescott, Hallie C, Brett, Stephen J, Weiss, Björn, Azoulay, Elie, Creteur, Jacques, Latronico, Nicola, Hough, Catherine L, Weber-Carstens, Steffen, Vincent, Jean-Louis, Preiser, Jean-Charles

“…Intensive care survivors often experience post-intensive care sequelae, which are frequently gathered together under the term "post-intensive care syndrome"…”
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Optimal intensive care outcome prediction over time using machine learning by Meiring, Christopher, Dixit, Abhishek, Harris, Steve, MacCallum, Niall S, Brealey, David A, Watkinson, Peter J, Jones, Andrew, Ashworth, Simon, Beale, Richard, Brett, Stephen J, Singer, Mervyn, Ercole, Ari

“…Prognostication is an essential tool for risk adjustment and decision making in the intensive care unit (ICU). Research into prognostication in ICU has so far…”
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Chronic pain in critical care survivors: a narrative review by Kemp, Harriet I, Laycock, Helen, Costello, Alice, Brett, Stephen J

“…Chronic pain is an important problem after critical care admission. Estimates of the prevalence of chronic pain in the year after discharge range from 14% to…”
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OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo by Wong, Joshua L. C., Romano, Maria, Kerry, Louise E., Kwong, Hok-Sau, Low, Wen-Wen, Brett, Stephen J., Clements, Abigail, Beis, Konstantinos, Frankel, Gad

“…Carbapenem-resistance in Klebsiella pneumoniae (KP) sequence type ST258 is mediated by carbapenemases (e.g. KPC-2) and loss or modification of the major…”
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An exploration of social and economic outcome and associated health-related quality of life after critical illness in general intensive care unit survivors: a 12-month follow-up study by Griffiths, John, Hatch, Robert A, Bishop, Judith, Morgan, Kayleigh, Jenkinson, Crispin, Cuthbertson, Brian H, Brett, Stephen J

“…The socio-economic impact of critical illnesses on patients and their families in Europe has yet to be determined. The aim of this exploratory study was to…”
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Cardiac Arrest and Cardiopulmonary Resuscitation Outcome Reports: Update of the Utstein Resuscitation Registry Templates for Out-of-Hospital Cardiac Arrest by Perkins, Gavin D, Jacobs, Ian G, Nadkarni, Vinay M, Berg, Robert A, Bhanji, Farhan, Biarent, Dominique, Bossaert, Leo L, Brett, Stephen J, Chamberlain, Douglas, de Caen, Allan R, Deakin, Charles D, Finn, Judith C, Gräsner, Jan-Thorsten, Hazinski, Mary Fran, Iwami, Taku, Koster, Rudolph W, Lim, Swee Han, Ma, Matthew Huei-Ming, McNally, Bryan F, Morley, Peter T, Morrison, Laurie J, Monsieurs, Koenraad G, Montgomery, William, Nichol, Graham, Okada, Kazuo, Ong, Marcus Eng Hock, Travers, Andrew H, Nolan, Jerry P

“…Abstract Utstein-style guidelines contribute to improved public health internationally by providing a structured framework with which to compare emergency…”
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The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study by Palmer, Edward, Post, Benjamin, Klapaukh, Roman, Marra, Giampiero, MacCallum, Niall S, Brealey, David, Ercole, Ari, Jones, Andrew, Ashworth, Simon, Watkinson, Peter, Beale, Richard, Brett, Stephen J, Young, J Duncan, Black, Claire, Rashan, Aasiyah, Martin, Daniel, Singer, Mervyn, Harris, Steve

“…There is conflicting evidence on harm related to exposure to supraphysiologic Pa (hyperoxemia) in critically ill patients. To examine the association between…”
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Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412 by Suntharalingam, Ganesh, Perry, Meghan R, Ward, Stephen, Brett, Stephen J, Castello-Cortes, Andrew, Brunner, Michael D, Panoskaltsis, Nicki

“…In a phase 1 trial, six healthy male volunteers received 0.1 mg per kilogram of body weight of a superagonistic anti-CD28 monoclonal antibody. Unexpectedly,…”
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The Effect of ICU Out-of-Hours Admission on Mortality: A Systematic Review and Meta-Analysis by Galloway, Megan, Hegarty, Aoife, McGill, Sarah, Arulkumaran, Nishkantha, Brett, Stephen J, Harrison, David

“…OBJECTIVES:Organizational factors are associated with outcome of critically ill patients and may vary by time of day and day of week. We aimed to identify the…”
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The influence of personality on psychological safety, the presence of stress and chosen professional roles in the healthcare environment by Grailey, Kate, Lound, Adam, Murray, Eleanor, Brett, Stephen J

“…Healthcare teams are expected to deliver high quality and safe clinical care, a goal facilitated by an environment of psychological safety. We hypothesised…”
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Recovery after critical illness: putting the puzzle together-a consensus of 29 by Azoulay, Elie, Vincent, Jean-Louis, Angus, Derek C, Arabi, Yaseen M, Brochard, Laurent, Brett, Stephen J, Citerio, Giuseppe, Cook, Deborah J, Curtis, Jared Randall, Dos Santos, Claudia C, Ely, E Wesley, Hall, Jesse, Halpern, Scott D, Hart, Nicholas, Hopkins, Ramona O, Iwashyna, Theodore J, Jaber, Samir, Latronico, Nicola, Mehta, Sangeeta, Needham, Dale M, Nelson, Judith, Puntillo, Kathleen, Quintel, Michael, Rowan, Kathy, Rubenfeld, Gordon, Van den Berghe, Greet, Van der Hoeven, Johannes, Wunsch, Hannah, Herridge, Margaret

“…In this review, we seek to highlight how critical illness and critical care affect longer-term outcomes, to underline the contribution of ICU delirium to…”
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Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review by Price, Laura C, Wort, Stephen J, Finney, Simon J, Marino, Philip S, Brett, Stephen J

“…Pulmonary vascular dysfunction, pulmonary hypertension (PH), and resulting right ventricular (RV) failure occur in many critical illnesses and may be…”
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Exploring the working environment of Hospital Managers: a mixed methods study investigating stress, stereotypes, psychological safety and individual resilience by Grailey, Kate, Leon-Villapalos, Clare, Murray, Eleanor, Brett, Stephen J

“…Abstract Background Hospital managers are responsible for the delivery of organisational strategy, development of clinical services and maintaining quality…”
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Widespread emergence of OmpK36 loop 3 insertions among multidrug-resistant clones of Klebsiella pneumoniae by David, Sophia, Wong, Joshua L C, Sanchez-Garrido, Julia, Kwong, Hok-Sau, Low, Wen Wen, Morecchiato, Fabio, Giani, Tommaso, Rossolini, Gian Maria, Brett, Stephen J, Clements, Abigail, Beis, Konstantinos, Aanensen, David M, Frankel, Gad

“…Mutations in outer membrane porins act in synergy with carbapenemase enzymes to increase carbapenem resistance in the important nosocomial pathogen, Klebsiella…”
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“I’d rather wait and see what’s around the corner”: A multi-perspective qualitative study of treatment escalation planning in frailty by Lound, Adam, Bruton, Jane, Jones, Kathryn, Shah, Nira, Williams, Barry, Gross, Jamie, Post, Benjamin, Day, Sophie, Brett, Stephen J, Ward, Helen

“…Introduction People living with frailty risk adverse outcomes following even minor illnesses. Admission to hospital or the intensive care unit is associated…”
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Author Correction: OmpK36-mediated Carbapenem resistance attenuates ST258 Klebsiella pneumoniae in vivo by Wong, Joshua L. C., Romano, Maria, Kerry, Louise E., Kwong, Hok-Sau, Low, Wen-Wen, Brett, Stephen J., Clements, Abigail, Beis, Konstantinos, Frankel, Gad

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Clinical and survival differences during separate COVID-19 surges: Investigating the impact of the Sars-CoV-2 alpha variant in critical care patients by Ritchie, Andrew I, Kadwani, Owais, Saleh, Dina, Baharlo, Behrad, Broomhead, Lesley R, Randell, Paul, Waheed, Umeer, Templeton, Maie, Brown, Elizabeth, Stümpfle, Richard, Patel, Parind, Brett, Stephen J, Soni, Sanooj

“…A number of studies have highlighted physiological data from the first surge in critically unwell Covid-19 patients but there is a paucity of data describing…”
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Supraglottic airway device versus tracheal intubation in the initial airway management of out-of-hospital cardiac arrest: the AIRWAYS-2 cluster RCT by Benger, Jonathan R, Kirby, Kim, Black, Sarah, Brett, Stephen J, Clout, Madeleine, Lazaroo, Michelle J, Nolan, Jerry P, Reeves, Barnaby C, Robinson, Maria, Scott, Lauren J, Smartt, Helena, South, Adrian, Stokes, Elizabeth A, Taylor, Jodi, Thomas, Matthew, Voss, Sarah, Wordsworth, Sarah, Rogers, Chris A

“…When a cardiac arrest occurs, cardiopulmonary resuscitation should be started immediately. However, there is limited evidence about the best approach to airway…”
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Clinician and patient perspectives on the barriers and facilitators to physical rehabilitation in intensive care: a qualitative interview study by Woodbridge, Huw R, Norton, Christine, Jones, Mandy, Brett, Stephen J, Alexander, Caroline M, Gordon, Anthony C

“…ObjectivesThe objective of this study is to explore patient, relative/carer and clinician perceptions of barriers to early physical rehabilitation in intensive…”
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