Search Results - "J A Lowe, 3rd"

Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity by Seeger, T F, Seymour, P A, Schmidt, A W, Zorn, S H, Schulz, D W, Lebel, L A, McLean, S, Guanowsky, V, Howard, H R, Lowe, 3rd, J A

“…Ziprasidone (CP-88,059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects in preclinical assays predictive of…”
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A Potent Nonpeptide Antagonist of the Substance P (NK$_1$) Receptor by Snider, R. Michael, Constantine, Jay W., Lowe, John A., Longo, Kelly P., Lebel, Wesley S., Woody, Heidi A., Drozda, Susan E., Desai, Manoj C., Vinick, Frederic J., Spencer, Robin W., Hess, Hans-Jürgen

“…CP-96,345 [(2S, 3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)-methyl]-1-azabicyclo[2.2.2] octan-3-amine] is a potent nonpeptide antagonist of the substance P…”
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Molecular basis for the species selectivity of the substance P antagonist CP-96,345 by B S Sachais, R M Snider, J A Lowe, 3rd, J E Krause

“…The non-peptide substance P (SP) antagonist CP-96,345 has a 90-fold selectivity for the human neurokinin-1 (NK-1) or SP receptor over the rat NK-1 receptor,…”
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Two nonpeptide tachykinin antagonists act through epitopes on corresponding segments of the NK1 and NK2 receptors by U Gether, Y Yokota, X Emonds-Alt, J C Brelière, J A Lowe, 3rd, R M Snider, S Nakanishi, T W Schwartz

“…The molecular mechanism of action for two chemically distinct and highly selective, nonpeptide antagonists, CP-96,345 and SR-48,968, was studied by development…”
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Activity and Distribution of Binding Sites in Brain of a Nonpeptide Substance P (NK$_1$) Receptor Antagonist by McLean, Stafford, Ganong, Alan H., Seeger, Thomas F., Bryce, Dianne K., Pratt, Kara G., Reynolds, Linda S., Siok, Chester J., Lowe, John A., Heym, James

“…CP-96,345, a nonpeptide substance P antagonist, is selective for the tachykinin NK$_1$ receptor. The compound binds to a single population of sites in guinea…”
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Selective Inhibition of the Carotid Body Sensory Response to Hypoxia by the Substance P Receptor Antagonist CP-96,345 by Prabhakar, Nanduri R., Cao, H., Lowe, J. A., Snider, R. M.

“…Carotid bodies are sensory organs for monitoring arterial oxygen and CO2. Previous studies have shown that chemoreceptor tissue contains substance P (SP) and…”
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Photoaffinity labeling of the human substance P (neurokinin-1) receptor with [3H2]azido-CP-96,345, a photoreactive derivative of a nonpeptide antagonist by MacDonald, D, Silberman, S C, Lowe, 3rd, J A, Drozda, S E, Leeman, S E, Boyd, N D

“…An azido derivative of [3H2](2S, 3S)-cis-2-(diphenylmethyl)-N-((2-methoxyphenyl) methyl)-1-azabicyclo[2.2.2]octon-3-amine (CP-96,345), a potent nonpeptide…”
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Effect of CP-96,345, a Nonpeptide Substance P Receptor Antagonist, on Salivation in Rats by Snider, R. Michael, Longo, Kelly P., Drozda, Susan E., Lowe, John A., Leeman, Susan E.

“…CP-96,345 {(2S,3S)-cis-2-(diphenylmethyl)-N-[(2-methoxyphenyl)methyl]-1 -azabicyclo[2.2.2]octa N-3-amine} antagonism of substance P-stimulated salivation was…”
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Specific residues at the top of transmembrane segment V and VI of the neurokinin-1 receptor involved in binding of the nonpeptide antagonist CP 96,345 [corrected] by U Gether, L Nilsson, J A Lowe, 3rd, T W Schwartz

“…Previously we have found that binding of the nonpeptide substance P antagonist, CP 96,345, to the neurokinin-1 (NK-1) receptor was critically dependent on two…”
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Different binding epitopes on the NK1 receptor for substance P and a non-peptide antagonist by GETHER, U, JOHANSEN, T. E, SNIDER, R. M, LOWE, J. A, NAKANISHI, S, SCHWARTZ, T. W

“…Non-peptide ligands for peptide receptors have been discovered in several systems through file screening programs, but the mechanism of action for these…”
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Effects of the cannabinoid CB1 receptor antagonist SR141716A on the behavior of pigeons and rats by MANSBACH, R. S, ROVETTI, C. C, WINSTON, E. N, LOWE, J. A

“…SR141716A (Sanofi Recherche), a pyrazole derivative with high affinity for rat and human CB1 cannabinoid receptors, has recently been reported to reverse…”
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Characterization of Non-peptide Antagonist and Peptide Agonist Binding Sites of the NK1 Receptor with Fluorescent Ligands by Turcatti, Gerardo, Zoffmann, Sannah, Lowe, John A., Drozda, Susan E., Chassaing, Gérard, Schwartz, Thue W., Chollet, André

“…Ligand recognition of the NK1 receptor (substance P receptor) by peptide agonist and non-peptide antagonist has been investigated and compared by the use of…”
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3-Benzisothiazolylpiperazine Derivatives as Potential Atypical Antipsychotic Agents by Howard, Harry R, Lowe, John A, Seeger, Thomas F, Seymour, Patricia A, Zorn, Stevin H, Maloney, Patrick R, Ewing, Frank E, Newman, Michael E, Schmidt, Anne W, Furman, Jerome S, Robinson, Gwendolyn L, Jackson, Elisa, Johnson, Celeste, Morrone, Jean

“…A series of substituted phenethyl derivatives of 3-benzisothiazolylpiperazine incorporating potent D2 and 5-HT2A antagonist activity was investigated as an…”
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5-Phenyl-3-ureidobenzazepin-2-ones as cholecystokinin-B receptor antagonists by Lowe, 3rd, J A, Hageman, D L, Drozda, S E, McLean, S, Bryce, D K, Crawford, R T, Zorn, S, Morrone, J, Bordner, J

“…A series of 5-phenyl-3-ureidobenzazepin-2-one cholecystokinin-B (CCK-B) receptor antagonists was synthesized using Beckmann ring expansion of a suitable…”
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Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist by Rosen, Terry J., Coffman, Karen J., McLean, Stafford, Crawford, Rosemary T., Bryce, Dianne K., Gohda, Yoshiko, Tsuchiya, Megumi, Nagahisa, Atsushi, Nakane, Masami, Lowe, John A.

“…The synthesis and SAR of benzylamine side chain analogs of the NK-1 receptor antagonist CP-99,994 are described. The 5-trifluoromethoxy analog, CP-122,721,…”
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A new class of selective and potent inhibitors of neuronal nitric oxide synthase by Lowe, John A., Qian, Weimin, Volkmann, Robert A., Heck, Steven, Nowakowski, Jolanta, Nelson, Robert, Nolan, Charles, Liston, Dane, Ward, Karen, Zorn, Stevin, Johnson, Celeste, Vanase, Michelle, Faraci, W. Stephen, Verdries, Kimberly A., Baxter, James, Doran, Shawn, Sanders, Martin, Ashton, Mike, Whittle, Peter, Stefaniak, Mark

“…The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this…”
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Nonpeptide tachykinin antagonists: medicinal chemistry and molecular biology by Lowe III, John A.

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Antiinflammatory and analgesic activity of a non-peptide substance P receptor antagonist by Nagahisa, A, Kanai, Y, Suga, O, Taniguchi, K, Tsuchiya, M, Lowe, 3rd, J A, Hess, H J

“…CP-96,345, a potent non-peptide antagonist of the substance P (SP) receptor, inhibited SP-, neurokinin A (NKA)- and neurokinin B-induced plasma extravasation…”
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Structure-activity relationship of quinazolinedione inhibitors of calcium-independent phosphodiesterase by Lowe, John A, Archer, Robert L, Chapin, Douglas S, Cheng, John B, Helweg, David, Johnson, Jonathan L, Koe, B. Kenneth, Lebel, Lorraine A, Moore, Peter F

“…A series of quinazolinediones and azaquinazolinediones is described which possess potent inhibitory activity toward the calcium-independent phosphodiesterase…”
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Tachykinin non-peptide antagonists: binding domain and molecular mode of action by Gether, U, Lowe, 3rd, J A, Schwartz, T W

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