Search Results - "Jürets, Alexander"

Inhibition of adenovirus replication by CRISPR-Cas9-mediated targeting of the viral E1A gene by Didara, Zrinka, Reithofer, Florian, Zöttl, Karina, Jürets, Alexander, Kiss, Izabella, Witte, Angela, Klein, Reinhard

“…DNA-targeting CRISPR-Cas systems are able to cleave dsDNA in mammalian cells. Accordingly, they have been employed to target the genomes of dsDNA viruses,…”
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Antibody-mediated targeting of cleavage-specific OPN-T cell interactions by Wanko, Bettina, Tardelli, Matteo, Jürets, Alexander, Neuhofer, Angelika, Prager, Gerhard, Morser, John, Leung, Lawrence L, Staffler, Günther, Zeyda, Maximilian, Stulnig, Thomas M

“…T cells are crucial players in obesity-mediated adipose tissue inflammation. We hypothesized that osteopontin (OPN), an inflammatory protein with enhanced…”
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Assessing protein immunogenicity with a dendritic cell line-derived endolysosomal degradome by Egger, Matthias, Jürets, Alexander, Wallner, Michael, Briza, Peter, Ruzek, Silke, Hainzl, Stefan, Pichler, Ulrike, Kitzmüller, Claudia, Bohle, Barbara, Huber, Christian G, Ferreira, Fátima

“…The growing number of novel candidate molecules for the treatment of allergic diseases imposed a dramatic increase in the demand for animal experiments to…”
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Immunological blockade of adipocyte inflammation caused by increased matrix metalloproteinase‐cleaved osteopontin in obesity by Leitner, Lukas, Schuch, Karina, Jürets, Alexander, Itariu, Bianca K., Keck, Maike, Grablowitz, Viktor, Aszmann, Oskar C., Prager, Gerhard, Staffler, Günther, Zeyda, Maximilian, Stulnig, Thomas M.

“…Objective Osteopontin (OPN) is upregulated in adipose tissue (AT) in obesity and contributes to subclinical inflammation, adipocyte dysfunction, and insulin…”
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Inhibition of Cellular Adhesion by Immunological Targeting of Osteopontin Neoepitopes Generated through Matrix Metalloproteinase and Thrombin Cleavage by Jürets, Alexander, Le Bras, Marie, Staffler, Günther, Stein, Gesine, Leitner, Lukas, Neuhofer, Angelika, Tardelli, Matteo, Turkof, Edvin, Zeyda, Maximilian, Stulnig, Thomas M

“…Osteopontin (OPN), a secreted protein involved in inflammatory processes and cancer, induces cell adhesion, migration, and activation of inflammatory pathways…”
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Osteopontin promotes aromatase expression and estradiol production in human adipocytes by Leitner, Lukas, Jürets, Alexander, Itariu, Bianca K., Keck, Maike, Prager, Gerhard, Langer, Felix, Grablowitz, Viktor, Zeyda, Maximilian, Stulnig, Thomas M.

“…Breast and endometrial cancer are often estrogen dependent, and their incidence and mortality are increased by obesity in postmenopausal women. Osteopontin…”
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Serum Myostatin is Upregulated in Obesity and Correlates with Insulin Resistance in Humans by Amor, Melina, Itariu, Bianca K, Moreno-Viedma, Veronica, Keindl, Magdalena, Jürets, Alexander, Prager, Gerhard, Langer, Felix, Grablowitz, Viktor, Zeyda, Maximilian, Stulnig, Thomas M

“…Obesity and type 2 diabetes mellitus have reached an epidemic level, thus novel treatment concepts need to be identified. Myostatin, a myokine known for…”
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Upregulated TNF Expression 1 Year After Bariatric Surgery Reflects a Cachexia-Like State in Subcutaneous Adipose Tissue by Jürets, Alexander, Itariu, Bianca Karla, Keindl, Magdalena, Prager, Gerhard, Langer, Felix, Grablowitz, Viktor, Zeyda, Maximilian, Stulnig, Thomas Michael

“…Background Adipose tissue dysfunction contributes to obesity-associated chronic diseases. In the first year after bariatric surgery, obese patients…”
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