Search Results - "Jørgensen, J. O. L"

Long-Term Efficacy and Safety of Pegvisomant in Combination With Long-Acting Somatostatin Analogs in Acromegaly by Neggers, S. J. C. M. M, Franck, S. E, de Rooij, F. W. M, Dallenga, A. H. G, Poublon, R. M. L, Feelders, R. A, Janssen, J. A. M. J. L, Buchfelder, M, Hofland, L. J, Jørgensen, J. O. L, van der Lely, A. J

“…Background: Treatment for acromegaly patients with long-acting somatotropin release-inhibiting factor (LA-SRIF) often does not result in complete normalization…”
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Insulin-Like Growth Factor (IGF) I, -II, and IGF Binding Protein-3 and Risk of Ischemic Stroke by Johnsen, S. P., Hundborg, H. H., Sørensen, H. T., Ørskov, H., Tjønneland, A., Overvad, K., Jørgensen, J. O. L.

“…Background: Low IGF-I levels may be associated with the development of stroke; however, prospective data appear to be unavailable. Methods: This was a nested…”
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Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity by Nellemann, B., Vendelbo, M. H., Nielsen, T. S., Bak, A. M., Høgild, M., Pedersen, S. B., Biensø, R. S., Pilegaard, H., Møller, N., Jessen, N., Jørgensen, J. O. L.

“…Aim Insulin resistance induced by growth hormone (GH) is linked to promotion of lipolysis by unknown mechanisms. We hypothesized that suppression of the…”
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Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise by Vendelbo, M H, Møller, A B, Treebak, J T, Gormsen, L C, Goodyear, L J, Wojtaszewski, J F P, Jørgensen, J O L, Møller, N, Jessen, N

“…phosphorylation of AS160 and TBC1D1 plays an important role for GLUT4 mobilization to the cell surface. The phosphorylation of AS160 and TBC1D1 in humans in…”
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Growth Hormone (GH)-Induced Insulin Resistance Is Rapidly Reversible: An Experimental Study in GH-Deficient Adults by Krusenstjerna-Hafstrøm, T, Clasen, B. F, Møller, N, Jessen, N, Pedersen, S. B, Christiansen, J. S, Jørgensen, J. O. L

“…Context: It is clinically relevant and of physiological interest to investigate whether GH-induced insulin resistance depends on the timing of GH exposure…”
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Impact of GH substitution on exercise capacity and muscle strength in GH-deficient adults: a meta-analysis of blinded, placebo-controlled trials by Rubeck, K. Z., Bertelsen, S., Vestergaard, P., Jørgensen, J. O. L.

“…Summary Background  Several but not all trials suggest that GH replacement in GH‐deficient adults improves aerobic exercise capacity, whereas its effect on…”
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Time-course effects of physiological free fatty acid surges on insulin sensitivity in humans by Gormsen, L.C, Nielsen, C, Jessen, N, Jørgensen, J.O.L, Møller, N

“…Aim: Physiological elevations of free fatty acids (FFAs) occur in bell-shaped surges lasting some hours, observed nocturnally, during exercise and…”
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Dose-response effects of free fatty acids on amino acid metabolism and ureagenesis by Gormsen, L.C, Gjedsted, J, Gjedde, S, Nørrelund, H, Christiansen, J.S, Schmitz, O, Jørgensen, J.O.L, Møller, N

“…Free fatty acids (FFAs) are important fuels and have vital protein-sparing effects, particularly during conditions of metabolic stress and fasting. However, it…”
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Insulin resistance after a 72-h fast is associated with impaired AS160 phosphorylation and accumulation of lipid and glycogen in human skeletal muscle by Vendelbo, M H, Clasen, B F F, Treebak, J T, Møller, L, Krusenstjerna-Hafstrøm, T, Madsen, M, Nielsen, T S, Stødkilde-Jørgensen, H, Pedersen, S B, Jørgensen, J O L, Goodyear, L J, Wojtaszewski, J F P, Møller, N, Jessen, N

“…During fasting, human skeletal muscle depends on lipid oxidation for its energy substrate metabolism. This is associated with the development of insulin…”
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Breast cancer risk in hyperprolactinemia: a population-based cohort study and meta-analysis of the literature by Dekkers, O M, Ehrenstein, V, Bengtsen, M, Farkas, D Kormendine, Pereira, A M, Sørensen, H T, Jørgensen, J O L

“…ObjectiveTo enhance the precision of the risk estimate for breast cancer in hyperprolactinemia patients by collecting more data and pooling our results with…”
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Testing for growth hormone deficiency in adults −  how to respond? by Jørgensen, J. O. L., Christiansen, J. S.

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The Ghrelin Response to Exercise before and after Growth Hormone Administration by Vestergaard, E. T., Dall, R., Lange, K. H. W., Kjaer, M., Christiansen, J. S., Jorgensen, J. O. L.

“…Context: We have previously shown that exercise-induced GH release is not mediated by ghrelin, but it remains to be studied whether the increase in GH may…”
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ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy by Luger, A, Broersen, L H A, Biermasz, N R, Biller, B M K, Buchfelder, M, Chanson, P, Jorgensen, J O L, Kelestimur, F, Llahana, S, Maiter, D, Mintziori, G, Petraglia, F, Verkauskiene, R, Webb, S M, Dekkers, O M

“…Pregnancies are rare in women with pituitary adenomas, which may relate to hormone excess from secretory subtypes such as prolactinomas or corticotroph…”
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Gender differences in growth hormone response to exercise before and after rhGH administration and the effect of rhGH on the hormone profile of fit normal adults by Giannoulis, M. G., Boroujerdi, M. A., Powrie, J., Dall, R., Napoli, R., Ehrnborg, C., Pentecost, C., Cittadini, A., Jørgensen, J. O. L., Sonksen, P. H.

“…Summary Objectives  Exercise is a potent physiological stimulus of GH secretion. We hypothesized that exogenous recombinant human growth hormone (rhGH)…”
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Pegvisomant in combination with long-acting somatostatin analogues in acromegaly: the role of the GH receptor deletion of exon 3 by Franck, S E, van der Lely, A J, Delhanty, P J D, Jørgensen, J O L, Neggers, S J C M M

“…BackgroundDoses of the GH receptor (GHR) antagonist pegvisomant (PEGV) that normalize insulin-like growth factor 1 (IGF1) levels vary widely among acromegaly…”
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Expression of somatostatin receptors on human pituitary adenomas in vivo and ex vivo by NIELSEN, S, MELLEMKJAER, S, RASMUSSEN, L. M, LEDET, T, OLSEN, N, BOJSEN-MØLLER, M, ASTRUP, J, WEEKE, J, JØRGENSEN, J. O. L

“…The distribution and biologic activity of somatostatin receptor subtypes (SSTR) in pituitary adenomas is not clarified, especially regarding clinically…”
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Abnormalities of whole body protein turnover, muscle metabolism and levels of metabolic hormones in patients with chronic heart failure by NØRRELUND, H., WIGGERS, H., HALBIRK, M., FRYSTYK, J., FLYVBJERG, A., BØTKER, H. E., SCHMITZ, O., JØRGENSEN, J. O. L., CHRISTIANSEN, J. S., MØLLER, N.

“… Objective.  It is well known that chronic heart failure (CHF) is associated with insulin resistance and cachexia, but little is known about the underlying…”
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Anabolic effects of oral leucine-rich protein with and without β-hydroxybutyrate on muscle protein metabolism in a novel clinical model of systemic inflammation—a randomized crossover trial by Mose, M, Brodersen, K, Rittig, N, Schmidt, J, Jessen, N, Mikkelsen, UR, Jørgensen, JOL, Møller, N

“…β-lactoglobulin (BLG) stimulates muscle protein synthesis and β-hydroxybutyrate (BHB) inhibits muscle breakdown. Whether combining the 2 can additively…”
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Mortality in Cushing's syndrome: A systematic review and meta-analysis by Graversen, D, Vestergaard, P, Stochholm, K, Gravholt, C.H, Jørgensen, J.O.L

“…Abstract Context Data on mortality associated with Cushing's disease (CD) and Cushing's syndrome (CS) are scarce. Objective To perform a systematic review and…”
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Effects of GH replacement therapy in adults on serum levels of leptin and ghrelin: the role of lipolysis by Vestergaard, E T, Hansen, T K, Nielsen, S, Moller, N, Christiansen, J S, Jorgensen, J O L

“…Objective: The regulation and function of systemic ghrelin levels appear to be associated with food intake and energy balance rather than GH. Since GH, in…”
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