Search Results - "Jörgensen, Johanna"

Cold acclimation recruits human brown fat and increases nonshivering thermogenesis by van der Lans, Anouk A J J, Hoeks, Joris, Brans, Boudewijn, Vijgen, Guy H E J, Visser, Mariëlle G W, Vosselman, Maarten J, Hansen, Jan, Jörgensen, Johanna A, Wu, Jun, Mottaghy, Felix M, Schrauwen, Patrick, van Marken Lichtenbelt, Wouter D

“…In recent years, it has been shown that humans have active brown adipose tissue (BAT) depots, raising the question of whether activation and recruitment of BAT…”
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Human skeletal muscle mitochondrial dynamics in relation to oxidative capacity and insulin sensitivity by Houzelle, Alexandre, Jörgensen, Johanna A., Schaart, Gert, Daemen, Sabine, van Polanen, Nynke, Fealy, Ciarán E., Hesselink, Matthijs K. C., Schrauwen, Patrick, Hoeks, Joris

“…Aims/hypothesis Mitochondria operate in networks, adapting to external stresses and changes in cellular metabolic demand and are subject to various quality…”
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Demonstration of a day-night rhythm in human skeletal muscle oxidative capacity by van Moorsel, Dirk, Hansen, Jan, Havekes, Bas, Scheer, Frank A.J.L, Jörgensen, Johanna A, Hoeks, Joris, Schrauwen-Hinderling, Vera B, Duez, Helene, Lefebvre, Philippe, Schaper, Nicolaas C, Hesselink, Matthijs K.C, Staels, Bart, Schrauwen, Patrick

“…Abstract Objective A disturbed day-night rhythm is associated with metabolic perturbations that can lead to obesity and type 2 diabetes mellitus (T2DM). In…”
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Distinct lipid droplet characteristics and distribution unmask the apparent contradiction of the athlete's paradox by Daemen, Sabine, Gemmink, Anne, Brouwers, Bram, Meex, Ruth C.R., Huntjens, Peter R., Schaart, Gert, Moonen-Kornips, Esther, Jörgensen, Johanna, Hoeks, Joris, Schrauwen, Patrick, Hesselink, Matthijs K.C.

“…Intramyocellular lipid (IMCL) storage negatively associates with insulin resistance, albeit not in endurance-trained athletes. We investigated the putative…”
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Genetic Markers of Brown Adipose Tissue Identity and In Vitro Brown Adipose Tissue Activity in Humans by Nascimento, Emmani B.M., Sparks, Lauren M., Divoux, Adeline, van Gisbergen, Marike W., Broeders, Evie P.M., Jörgensen, Johanna A., Schaart, Gert, Bouvy, Nicole D., van Marken Lichtenbelt, Wouter D., Schrauwen, Patrick

“…Objective Human brown adipose tissue (BAT) activity decreases with age and obesity. In addition to uncoupling protein 1 (UCP1), several genetic markers of BAT…”
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Dissociation of intramyocellular lipid storage and insulin resistance in trained athletes and type 2 diabetes patients; involvement of perilipin 5? by Gemmink, Anne, Daemen, Sabine, Brouwers, Bram, Huntjens, Peter R., Schaart, Gert, Moonen‐Kornips, Esther, Jörgensen, Johanna, Hoeks, Joris, Schrauwen, Patrick, Hesselink, Matthijs K. C.

“…Key points Intramyocellular lipid storage is negatively associated with insulin sensitivity. However, endurance trained athletes and type 2 diabetes mellitus…”
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Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals by Wefers, Jakob, Connell, Niels J., Fealy, Ciarán E., Andriessen, Charlotte, de Wit, Vera, van Moorsel, Dirk, Moonen-Kornips, Esther, Jörgensen, Johanna A., Hesselink, Matthijs K.C., Havekes, Bas, Hoeks, Joris, Schrauwen, Patrick

“…Skeletal muscle mitochondrial function and energy metabolism displays day-night rhythmicity in healthy, young individuals. Twenty-four-hour rhythmicity of…”
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Evaluation of Muscle microRNA Expression in Relation to Human Peripheral Insulin Sensitivity: A Cross-Sectional Study in Metabolically Distinct Subject Groups by Dahlmans, Dennis, Houzelle, Alexandre, Jörgensen, Johanna A, Phielix, Esther, Lindeboom, Lucas, Hesselink, Matthijs K C, Schrauwen, Patrick, Hoeks, Joris

“…In recent years, several microRNAs (miRNAs)-post-transcriptional regulators of gene expression-have been linked to the regulation of peripheral insulin…”
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PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans by de Wit-Verheggen, Vera H. W., Schrauwen-Hinderling, Vera B., Brouwers, Kim, Jörgensen, Johanna A., Schaart, Gert, Gemmink, Anne, Nascimento, Emmani B. M., Hesselink, Matthijs K. C., Wildberger, Joachim E., Segers, Patrique, Montaigne, David, Staels, Bart, Schrauwen, Patrick, Lindeboom, Lucas, Hoeks, Joris, van de Weijer, Tineke

“…Cardiac energy status, measured as phosphocreatine (PCr)/adenosine triphosphate (ATP) ratio with 31P-Magnetic Resonance Spectroscopy (31P-MRS) in vivo, is a…”
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Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial by van Beek, Sten M. M., Bruls, Yvonne M. H., Vanweert, Froukje, Fealy, Ciarán E., Connell, Niels J., Schaart, Gert, Moonen-Kornips, Esther, Jörgensen, Johanna A., Vaz, Frédéric M., Smeets, Ellen T. H. C., Joris, Peter J., Gemmink, Anne, Houtkooper, Riekelt H., Hesselink, Matthijs K. C., Bengtsson, Tore, Havekes, Bas, Schrauwen, Patrick, Hoeks, Joris

“…β 2 -agonist treatment improves skeletal muscle glucose uptake and whole-body glucose homeostasis in rodents, likely via mTORC2-mediated signalling. However,…”
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Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes by Jörgensen, Johanna A, Zadravec, Damir, Jacobsson, Anders

“…The Elovl3 gene, which putatively encodes for a protein involved in the elongation of saturated and monounsaturated fatty acids in the C20-C24 range, is…”
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An unbiased silencing screen in muscle cells identifies miR-320a, miR-150, miR-196b, and miR-34c as regulators of skeletal muscle mitochondrial metabolism by Dahlmans, Dennis, Houzelle, Alexandre, Andreux, Pénélope, Jörgensen, Johanna A., Wang, Xu, de Windt, Leon J., Schrauwen, Patrick, Auwerx, Johan, Hoeks, Joris

“…Strategies improving skeletal muscle mitochondrial capacity are commonly paralleled by improvements in (metabolic) health. We and others previously identified…”
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Differential regulation of fatty acid elongation enzymes in brown adipocytes implies a unique role for Elovl3 during increased fatty acid oxidation by Jakobsson, Andreas, Jörgensen, Johanna A, Jacobsson, Anders

“…The expression of the Elovl3 gene, which belongs to the Elovl gene family coding for microsomal enzymes involved in very long-chain fatty acid (VLCFA)…”
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Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus by Hanssen, Mark J W, Hoeks, Joris, Brans, Boudewijn, van der Lans, Anouk A J J, Schaart, Gert, van den Driessche, José J, Jörgensen, Johanna A, Boekschoten, Mark V, Hesselink, Matthijs K C, Havekes, Bas, Kersten, Sander, Mottaghy, Felix M, van Marken Lichtenbelt, Wouter D, Schrauwen, Patrick

“…A small clinical trial shows that short-term cold acclimation to moderately-cold temperature improves the glucose homeostasis of individuals with type 2…”
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MicroRNA‐204‐5p modulates mitochondrial biogenesis in C2C12 myotubes and associates with oxidative capacity in humans by Houzelle, Alexandre, Dahlmans, Dennis, Nascimento, Emmani B. M., Schaart, Gert, Jörgensen, Johanna A., Moonen‐Kornips, Esther, Kersten, Sander, Wang, Xu, Hoeks, Joris

“…Using an unbiased high‐throughput microRNA (miRNA)‐silencing screen combined with functional readouts for mitochondrial oxidative capacity in C2C12 myocytes,…”
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Nicotinamide Riboside Enhances In Vitro Beta-adrenergic Brown Adipose Tissue Activity in Humans by Nascimento, Emmani B M, Moonen, Michiel P B, Remie, Carlijn M E, Gariani, Karim, Jörgensen, Johanna A, Schaart, Gert, Hoeks, Joris, Auwerx, Johan, van Marken Lichtenbelt, Wouter D, Schrauwen, Patrick

“…Abstract Context Elevating nicotinamide adenine dinucleotide (NAD+) levels systemically improves metabolic health, which can be accomplished via nicotinamide…”
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Effects of the sodium-glucose cotransporter 2 inhibitor dapagliflozin on substrate metabolism in prediabetic insulin resistant individuals: A randomized, double-blind crossover trial by Veelen, Anna, Andriessen, Charlotte, Op den Kamp, Yvo, Erazo-Tapia, Edmundo, de Ligt, Marlies, Mevenkamp, Julian, Jörgensen, Johanna A., Moonen-Kornips, Esther, Schaart, Gert, Esterline, Russell, Havekes, Bas, Oscarsson, Jan, Schrauwen-Hinderling, Vera B., Phielix, Esther, Schrauwen, Patrick

“…Sodium-glucose cotransporter 2 inhibitor (SGLT2i) treatment in type 2 diabetes mellitus patients results in glucosuria, causing an energy loss, and triggers…”
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Genome‐informed approach to identify genetic determinants of Flavobacterium psychrophilum phage susceptibility by Daniel, Castillo, Johanna, Jørgensen, Krister, Sundell, Lone, Madsen, Inger, Dalsgaard, Tom, Wiklund, Mathias, Middelboe

“…Summary The fish pathogen Flavobacterium psychrophilum infects farmed salmonids worldwide, and application of bacteriophages has been suggested for controlling…”
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MicroRNA‐382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells by Dahlmans, Dennis, Houzelle, Alexandre, Andreux, Pénélope, Wang, Xu, Jörgensen, Johanna A., Moullan, Norman, Daemen, Sabine, Kersten, Sander, Auwerx, Johan, Hoeks, Joris

“…Proper mitochondrial function plays a central role in cellular metabolism. Various diseases as well as aging are associated with diminished mitochondrial…”
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Sitting less elicits metabolic responses similar to exercise and enhances insulin sensitivity in postmenopausal women by Remie, Carlijn M. E., Janssens, Georges E., Bilet, Lena, van Weeghel, Michel, Duvivier, Bernard M. F. M., de Wit, Vera H. W., Connell, Niels J., Jörgensen, Johanna A., Schomakers, Bauke V., Schrauwen-Hinderling, Vera B., Hoeks, Joris, Hesselink, Matthijs K. C., Phielix, Esther, Houtkooper, Riekelt H., Schrauwen, Patrick

“…Aims/hypothesis In our current society sedentary behaviour predominates in most people and is associated with the risk of developing type 2 diabetes. It has…”
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