Search Results - "Jörgensen, Arne"

The power of sulfhydryl groups: Thiolated lipid-based nanoparticles enhance cellular uptake of nucleic acids by Stengel, Daniel, Jörgensen, Arne M., Polidori, Ilaria, Kapitza, Paul, Ricci, Fabrizio, Bernkop-Schnürch, Andreas

“…The aim of the study was to evaluate the effect of thiolation of lipid-based nanoparticles (LNPs) on cellular uptake of nucleic acids.AIMThe aim of the study…”
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In Vitro Investigation of Thiolated Chitosan Derivatives as Mucoadhesive Coating Materials for Solid Lipid Nanoparticles by Wibel, Richard, Braun, Doris E, Hämmerle, Laurenz, Jörgensen, Arne M, Knoll, Patrick, Salvenmoser, Willi, Steinbring, Christian, Bernkop-Schnürch, Andreas

“…In the present study, chitosan (CS) was thiolated by introducing l-cysteine via amide bond formation. Free thiol groups were protected with highly reactive…”
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Cosolvents in Self-Emulsifying Drug Delivery Systems (SEDDS): Do They Really Solve Our Solubility Problems? by Jörgensen, Arne Matteo, Friedl, Julian David, Wibel, Richard, Chamieh, Joseph, Cottet, Hervé, Bernkop-Schnürch, Andreas

“…The aim of this study was to investigate the fate and the impact of cosolvents in self-emulsifying drug delivery systems (SEDDS). Three different SEDDS…”
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Biodegradable Cationic and Ionizable Cationic Lipids: A Roadmap for Safer Pharmaceutical Excipients by Jörgensen, Arne Matteo, Wibel, Richard, Bernkop‐Schnürch, Andreas

“…Cationic and ionizable cationic lipids are broadly applied as auxiliary agents, but their use is associated with adverse effects. If these excipients are…”
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Power-Up for Mucoadhesiveness: Two Generations of Thiolated Surfactants for Enhanced Sticky Nanoemulsions by To, Dennis, Kali, Gergely, Haddadzadegan, Soheil, Jörgensen, Arne Matteo, Nigl, Katharina, Ricci, Fabrizio, Bernkop-Schnürch, Andreas

“…Nanoemulsions can be tuned toward enhanced gastro-intestinal retention time by incorporating thiolated surfactants into their surface. Tailoring the chemical…”
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Comparative Analysis of PEG‐Free and PEG‐Based Self‐Emulsifying Drug Delivery Systems for Enhanced Oral Bioavailability of Therapeutic (Poly) Peptides by Haddadzadegan, Soheil, To, Dennis, Matteo Jörgensen, Arne, Wibel, Richard, Laffleur, Flavia, Bernkop‐Schnürch, Andreas

“…This study aims to compare the potential of Polyethylene glycol (PEG‐free and PEG‐based self‐emulsifying drug delivery systems (SEDDS) for the oral…”
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Self‐Emulsifying Drug Delivery Systems (SEDDS) Containing Reverse Micelles: Advanced Oral Formulations for Therapeutic Peptides by Jörgensen, Arne Matteo, Steinbring, Christian, Stengel, Daniel, To, Dennis, Schmid, Pascal, Bernkop‐Schnürch, Andreas

“…Alternative methods to hydrophobic ion pairing for the formation of lipophilic complexes of peptide drugs to incorporate them in lipid‐based nanocarriers such…”
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New Insights to Clathrin and Adaptor Protein 2 for the Design and Development of Therapeutic Strategies by Poulsen, Ebbe Toftgaard, Larsen, Agnete, Zollo, Alen, Jørgensen, Arne L, Sanggaard, Kristian W, Enghild, Jan J, Matrone, Carmela

“…The Amyloid Precursor Protein (APP) has been extensively studied for its role as the precursor of the β-amyloid protein (Aβ) in Alzheimer's disease (AD)…”
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Examining the homeostatic distribution of metals and Zn isotopes in Göttingen minipigs by Mahan, Brandon, Moynier, Frédéric, Jørgensen, Arne Lund, Habekost, Mette, Siebert, Julien

“…The role of metals in biologic systems is manifold, and understanding their behaviour in bodily processes, especially those relating to neurodegenerative…”
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Replacing PEG-surfactants in self-emulsifying drug delivery systems: Surfactants with polyhydroxy head groups for advanced cytosolic drug delivery by Friedl, Julian David, Jörgensen, Arne Matteo, Nguyen Le, Nguyet-Minh, Steinbring, Christian, Bernkop-Schnürch, Andreas

“…[Display omitted] •Polyethylene glycol- (PEG-) surfactants in self-emulsifying drug delivery system (SEDDS) can be successfully substituted by surfactants…”
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New Natures: Joining Environmental History with Science and Technology Studies by Dolly Jorgensen, Finn Arne Jorgensen, Sara Pritchard

“…New Naturesbroadens the dialogue between the disciplines of science and technology studies (STS) and environmental history in hopes of deepening and even…”
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MicroRNAs and Ascl1 facilitate direct conversion of porcine fibroblasts into induced neurons by Habekost, Mette, Jørgensen, Arne Lund, Qvist, Per, Denham, Mark

“…•Combined actions of miR-9/9*-124 and Ascl1 convert porcine fibroblasts into neurons.•Porcine induced neurons express common mature, glutamatergic and…”
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Directly Reprogrammed Neurons Express MAPT and APP Splice Variants Pertinent to Ageing and Neurodegeneration by Habekost, Mette, Qvist, Per, Denham, Mark, Holm, Ida E., Jørgensen, Arne Lund

“…Neurons produced by reprogramming of other cell types are used to study cellular mechanisms of age-related neurodegenerative diseases. To model Alzheimer’s…”
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Transcriptomic profiling of porcine pluripotency identifies species-specific reprogramming requirements for culturing iPSCs by Habekost, Mette, Jørgensen, Arne Lund, Qvist, Per, Denham, Mark

“…•Transcriptomic profiling of porcine, murine and human stem cells was performed.•Porcine embryonic stem cell (ESC) transcriptome resembles naïve-state human…”
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An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients by Poulsen, Ebbe T, Iannuzzi, Filomena, Rasmussen, Helle F, Maier, Thorsten J, Enghild, Jan J, Jørgensen, Arne L, Matrone, Carmela

“…Alzheimer's disease (AD) is the most common cause of dementia and is likely caused by defective amyloid precursor protein (APP) trafficking and processing in…”
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Longitudinal biometal accumulation and Ca isotope composition of the Göttingen minipig brain by Mahan, Brandon, Antonelli, Michael A, Burckel, Pierre, Turner, Simon, Chung, Roger, Habekost, Mette, Jørgensen, Arne Lund, Moynier, Frédéric

“…Biometals play a critical role in both the healthy and diseased brain's functioning. They accumulate in the normal aging brain, and are inherent to…”
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Soil contribution to the cobalamin (vitamin B12) supply of terrestrial organisms by Jörgensen, Arne Matteo, Joergensen, Rainer Georg

“…Cobalamin (Vitamin B 12 ) is a cofactor for many enzymes, including those in bacteria, archaea, algae, and mammals. In humans, cobalamin deficiency can lead to…”
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Expression of the Alzheimer's Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs by Jakobsen, Jannik E, Johansen, Marianne G, Schmidt, Mette, Liu, Ying, Li, Rong, Callesen, Henrik, Melnikova, Margarita, Habekost, Mette, Matrone, Carmela, Bouter, Yvonne, Bayer, Thomas A, Nielsen, Anders Lade, Duthie, Monika, Fraser, Paul E, Holm, Ida E, Jørgensen, Arne Lund

“…Mutations in the amyloid-β protein precursor gene (AβPP), the presenilin 1 gene (PSEN1) or the presenilin 2 gene (PSEN2) that increase production of the…”
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Oral drug delivery: Influence of mucus on cellular interactions and uptake of lipid-based nanocarriers in Caco-2 cells by Veider, Florina, Knoll, Patrick, Jörgensen, Arne Matteo, Stengel, Daniel, Bernkop-Schnürch, Andreas

“…This study aimed to investigate the impact of the mucus gel barrier on intestinal mucosal uptake of lipid-based nanocarriers (NCs). Zwitterionic- (ZW),…”
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Oral delivery of calcitonin-ion pairs: In vivo proof of concept for a highly lipophilic counterion by Wibel, Richard, Jörgensen, Arne Matteo, Laffleur, Flavia, Spleis, Helen, Claus, Victor, Bernkop-Schnürch, Andreas

“…[Display omitted] •Hydrophobic ion pair (HIP) formed with bis(isotridecyl) sulfosuccinate yielded higher lipophilicity than other counterions.•Bis(isotridecyl)…”
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