Search Results - "Jörg Huwyler"

PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application by Grossen, Philip, Witzigmann, Dominik, Sieber, Sandro, Huwyler, Jörg

“…The lack of efficient therapeutic options for many severe disorders including cancer spurs demand for improved drug delivery technologies. Nanoscale drug…”
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Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications by Wicki, Andreas, Witzigmann, Dominik, Balasubramanian, Vimalkumar, Huwyler, Jörg

“…Cancer is a leading cause of death worldwide. Currently available therapies are inadequate and spur demand for improved technologies. Rapid growth in…”
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Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery by Buck, Jonas, Grossen, Philip, Cullis, Pieter R, Huwyler, Jörg, Witzigmann, Dominik

“…Gene therapy is a promising strategy for the treatment of monogenic disorders. Non-viral gene delivery systems including lipid-based DNA therapeutics offer the…”
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Mechanisms of increased bioavailability through amorphous solid dispersions: a review by Schittny, Andreas, Huwyler, Jörg, Puchkov, Maxim

“…Amorphous solid dispersions (ASDs) can increase the oral bioavailability of poorly soluble drugs. However, their use in drug development is comparably rare due…”
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Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake by Campbell, Frederick, Bos, Frank L, Sieber, Sandro, Arias-Alpizar, Gabriela, Koch, Bjørn E, Huwyler, Jörg, Kros, Alexander, Bussmann, Jeroen

“…Up to 99% of systemically administered nanoparticles are cleared through the liver. Within the liver, most nanoparticles are thought to be sequestered by…”
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Zebrafish as a preclinical in vivo screening model for nanomedicines by Sieber, Sandro, Grossen, Philip, Bussmann, Jeroen, Campbell, Frederick, Kros, Alexander, Witzigmann, Dominik, Huwyler, Jörg

“…The interactions of nanomedicines with biological environments is heavily influenced by their physicochemical properties. Formulation design and optimization…”
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Calcium Phosphate Microcapsules as Multifunctional Drug Delivery Devices by Kost, Jonas, Huwyler, Jörg, Puchkov, Maxim

“…Abstract More challenging active pharmaceutical ingredients are entering the market, spurring the introduction of novel drug delivery strategies that…”
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Polyethylenimine (PEI) in gene therapy: Current status and clinical applications by Casper, Jens, Schenk, Susanne H., Parhizkar, Elahehnaz, Detampel, Pascal, Dehshahri, Ali, Huwyler, Jörg

“…Polyethlyenimine (PEI) was introduced 1995 as a cationic polymer for nucleic acid delivery. PEI and its derivatives are extensively used in basic research and…”
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The processes behind drug loading and release in porous drug delivery systems by Farzan, Maryam, Roth, Roger, Schoelkopf, Joachim, Huwyler, Jörg, Puchkov, Maxim

“…[Display omitted] Porous materials are ubiquitous and exhibit properties suitable for depositing therapeutic compounds. Drug loading in porous materials can…”
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Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo by Sieber, Sandro, Grossen, Philip, Detampel, Pascal, Siegfried, Salome, Witzigmann, Dominik, Huwyler, Jörg

“…Nanomedicines have gained much attention for the delivery of small molecules or nucleic acids as treatment options for many diseases. However, the transfer…”
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Interactions between silica nanoparticles and phospholipid membranes by Kettiger, Helene, Québatte, Gabriela, Perrone, Barbara, Huwyler, Jörg

“…Silica nanoparticles (SNPs) are widely used for biomedical applications. However, their parenteral administration may induce hemolysis. Molecular mechanisms…”
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Part I: Significant reduction of lyophilization process times by using novel matrix based scaffolds by Kullmann, Daniel, Martinez, Carmen Lema, Lümkemann, Jörg, Huwyler, Jörg

“…[Display omitted] To improve the long-term stability of drugs with limited stability (e.g., biologicals such as monoclonal antibodies, antibody drug conjugates…”
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Stereolithographic 3D printing: Formulation design based on percolation thresholds by Linares, Vicente, Casas, Marta, Huwyler, Jörg, Caraballo, Isidoro

“…Stereolithograpy (SLA) is an optical photosolidification technology, which can be used to produce 3D printed dosage forms. In the present work, the model drug…”
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Self‐assembling chitosan hydrogel: A drug‐delivery device enabling the sustained release of proteins by Kiene, Klara, Porta, Fabiola, Topacogullari, Buket, Detampel, Pascal, Huwyler, Jörg

“…ABSTRACT The development of a self‐assembling hydrogel, prepared from maleimide‐modified and thiolated chitosan (CS), is described. Under mild reaction…”
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Directional freezing and thawing of biologics in drug substance bottles by Peláez, Sarah S., Mahler, Hanns-Christian, Huwyler, Jörg, Allmendinger, Andrea

“…[Display omitted] Biological drug substance (DS) is typically stored frozen to increase stability. However, freezing and thawing (F/T) of DS can impact product…”
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Part II: Matrix based scaffold lyophilization facilitates processing as a prerequisite for an innovative packaging system by Kullmann, Daniel, Lema Martinez, Carmen, Lümkemann, Jörg, Huwyler, Jörg

“…[Display omitted] On large manufacturing lines, the fill finish process of drugs is generally accomplished by filling vials and syringes with their respective…”
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Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations by Riede, Julia, Poller, Birk, Huwyler, Jörg, Camenisch, Gian

“…Inhibition of the bile salt export pump (BSEP) has been recognized as a key factor in the development of drug-induced cholestasis (DIC). The risk of DIC in…”
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Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data by Kunze, Annett, Huwyler, Jörg, Camenisch, Gian, Poller, Birk

“…Organic anion-transporting polypeptides (OATP) 1B1 and OATP1B3 are drug transporters mediating the active hepatic uptake of their substrates. Because they…”
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A deep-learning-based workflow for reconstructing and segmenting challenging sets of time-resolved X-ray micro-computed tomography data by Waldner, Samuel, Huwyler, Jörg, Puchkov, Maxim

“…We present a deep-learning-based software pipeline for reconstructing and segmenting large sets of time-resolved micro-computed tomography (µCT) image data. We…”
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Poly(Sarcosine) Surface Modification Imparts Stealth‐Like Properties to Liposomes by Bleher, Stefan, Buck, Jonas, Muhl, Christian, Sieber, Sandro, Barnert, Sabine, Witzigmann, Dominik, Huwyler, Jörg, Barz, Matthias, Süss, Regine

“…Circulation lifetime is a crucial parameter for a successful therapy with nanoparticles. Reduction and alteration of opsonization profiles by surface…”
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