Search Results - "Józsi, M."

Deletion of Lys224 in regulatory domain 4 of Factor H reveals a novel pathomechanism for dense deposit disease (MPGN II) by Licht, C., Heinen, S., Józsi, M., Löschmann, I., Saunders, R.E., Perkins, S.J., Waldherr, R., Skerka, C., Kirschfink, M., Hoppe, B., Zipfel, P.F.

“…We report a novel pathomechanism for membranoproliferative glomerulonephritis type II (MPGN II) caused by a mutant Factor H protein expressed in the plasma…”
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The C‐terminus of complement regulator Factor H mediates target recognition: evidence for a compact conformation of the native protein by Oppermann, M., Manuelian, T., Józsi, M., Brandt, E., Jokiranta, T. S., Heinen, S., Meri, S., Skerka, C., Götze, O., Zipfel, P. F.

“…Summary The complement inhibitor Factor H has three distinct binding sites for C3b and for heparin, but in solution uses specifically the most C‐terminal…”
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Monomeric CRP contributes to complement control in fluid phase and on cellular surfaces and increases phagocytosis by recruiting factor H by Mihlan, M, Stippa, S, Józsi, M, Zipfel, P F

“…Complement forms the first defense line of innate immunity and has an important role in the non-inflammatory clearance of apoptotic and necrotic cells. Factor…”
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Human complement regulators interact with leptospiral immunoglobulin-like proteins contributing to immune evasion by Castiblanco-Valencia, M.M., Fraga, T.R., Silva, L.B., Monaris, D., Abreu, P.A.E., Strobel, S., Józsi, M., Isaac, L., Barbosa, A.S.

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Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with membranoproliferative glomerulonephritis type II (dense deposit disease) by Abrera-Abeleda, M A, Nishimura, C, Smith, J L H, Sethi, S, McRae, J L, Murphy, B F, Silvestri, G, Skerka, C, Józsi, M, Zipfel, P F, Hageman, G S, Smith, R J H

“…Introduction: Membranoproliferative glomerulonephritis type II or dense deposit disease (MPGN II/DDD) causes chronic renal dysfunction that progresses to end…”
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A further link between innate and adaptive immunity: C3 deposition on antigen-presenting cells enhances the proliferation of antigen-specific T cells by Kerekes, K, Prechl, J, Bajtay, Z, Józsi, M, Erdei, A

“…Murine cells of the B lymphoblastoid line A20 and concanavalin A-elicited peritoneal macrophages are shown to activate and fix C3 fragments covalently when…”
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Adjuvant effect of γ-inulin is mediated by C3 fragments deposited on antigen-presenting cells by Kerekes, Krisztina, Cooper, Peter D., Prechl, József, Józsi, Mihály, Bajtay, Zsuzsa, Erdei, Anna

“…The adjuvant effect of γ‐inulin, a strong activator of the alternative complement pathway, is well‐known, but its exact mechanism is not revealed yet. Here, we…”
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Mannan‐binding lectin and C1q bind to distinct structures and exert differential effects on macrophages by Bajtay, Zsuzsa, Józsi, Mihály, Bánki, Zoltán, Thiel, Steffen, Thielens, Nicole, Erdei, Anna

“…While the interaction of complement component C1q with cellular proteins is extensively studied, much less is known about the binding of the structurally…”
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Factor H-related protein 4 can serve as a platform for the assembly of an active C3 convertase via its interaction with C3b by Hebecker, M., Józsi, M.

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Attachment of the soluble complement regulator factor H to cell and tissue surfaces: relevance for pathology by Józsi, M, Manuelian, T, Heinen, S, Oppermann, M, Zipfel, P F

“…Complement is a central element of innate immunity and this vital defense system initiates and coordinates immediate immune reactions which attack and…”
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Impaired binding of factor H to pentraxin 3 due to factor H mutations and autoantibodies associated with atypical hemolytic uremic syndrome by Braunschweig, A., Strobel, S., Jozsi, M.

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Characterization of factor H-related cell membrane molecules expressed by human B lymphocytes and neutrophil granulocytes by Józsi, Mihály, Kapus, Attila, Kerekes, Krisztina, Kármán, József, Bajtay, Zsuzsa, Zipfel, Peter F, Erdei, Anna

“…The human factor H protein family comprises six plasma glycoproteins. Earlier we described a membranal factor H-related (mFHR) molecule that is expressed by…”
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Secreted aspartic protease 2 of Candida albicans cleaves factor H and the macrophage factor H-receptors by Svobodová, E., Staib, P., Kremlitzka, M., Barz, D., Józsi, M.

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Monoclonal anti-factor H antibodies in dense deposit disease by López-Trascasa, M., Alba, M., López-Lera, A., Ibernon, M., Garrido, S., Rodríguez de Córdoba, S., Jozsi, M., López-Trascasa, M.

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Comprehensive functional characterization of an engineered factor H construct combining complement regulatory and surface recognition domains by Hebecker, M., Alba-Domínguez, M., Roumenina, L.T., Reuter, S., Hyvärinen, S., Dragon-Durey, M.-A., Jokiranta, T.S., Sánchez-Corral, P., Józsi, M.

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Factor H family proteins and human diseases by Józsi, Mihály, Zipfel, Peter F

“…Complement is a major defense system of innate immunity and aimed to destroy microbes. One of the central complement regulators is factor H, which belongs to a…”
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Complement and diseases: Defective alternative pathway control results in kidney and eye diseases by Zipfel, Peter F., Heinen, Stefan, Józsi, Mihály, Skerka, Christine

“…The complement system is a central part of innate immunity and in its normal setting aimed to recognize and eliminate microbes. For elimination toxic…”
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Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome by Manuelian, T, Hellwage, J, Meri, S, Caprioli, J, Noris, M, Heinen, S, Jozsi, M, Neumann, HPH, Remuzzi, G, Zipfel, P F

“…Hemolytic uremic syndrome (HUS) is a disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Recent studies have…”
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Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome by Strobel, Stefanie, Hoyer, Peter F., Mache, Christoph J., Sulyok, Endre, Liu, Wei-shih, Richter, Heiko, Oppermann, Martin, Zipfel, Peter F., Józsi, Mihály

“…Background. Atypical haemolytic uraemic syndrome (aHUS) is associated with defective complement regulation. Recently, an autoimmune aHUS form has been…”
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Binding of Complement Factor H to Endothelial Cells Is Mediated by the Carboxy-Terminal Glycosaminoglycan Binding Site by Jokiranta, T. Sakari, Cheng, Zhu-Zhu, Seeberger, Harald, Jòzsi, Mihály, Heinen, Stefan, Noris, Marina, Remuzzi, Giuseppe, Ormsby, Rebecca, Gordon, David L., Meri, Seppo, Hellwage, Jens, Zipfel, Peter F.

“…Factor H (FH), the major fluid phase regulator of the alternative complement pathway, mediates protection of plasma-exposed host structures. It has recently…”
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