Search Results - "Järlebark, L"

Differential gene expression in the rat cochlea after exposure to impulse noise by Kirkegaard, M., Murai, N., Risling, M., Suneson, A., Järlebark, L., Ulfendahl, M.

“…Understanding the molecular biology of noise trauma is vital to developing effective and timely interventions. In a model of explosion-mediated impulse noise…”
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Mercury (Hg 2+) suppression of potassium currents of outer hair cells by Liang, G.-H., Järlebark, L., Ulfendahl, M., Moore, E.J.

“…The heavy metal mercury (Hg 2+) is an insidious environmental pollutant that causes toxic effects on sensory systems. It is well known that the group IIB…”
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Lead (Pb 2+) modulation of potassium currents of guinea pig outer hair cells by Liang, G.-H, Järlebark, L, Ulfendahl, M, Bian, J.-T, Moore, E.J

“…Outer hair cells (OHC) are mechanosensitive sensory cells of the inner ear cochlea and are involved in modulating the activity of inner hair cells in the…”
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ATP-induced cytoplasmic [Ca2+] increases in isolated cochlear outer hair cells. Involved receptor and channel mechanisms by Nilles, R, Järlebark, L, Zenner, H P, Heilbronn, E

“…Outer hair cells (OHC) of the mammalian cochlea are thought to preprocess the sound signal by active movements, which can be induced by electrical or chemical…”
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Ligand-binding properties of an unusual nicotinic acetylcholine receptor subtype on isolated outer hair cells from guinea pig cochlea by Lawoko, G., Järlebark, L., Heilbronn, E.

“…Acetylcholine receptors on isolated guinea pig cochlear outer hair cells (OHC) were characterized by radioligand binding. Equilibrium binding of […”
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Expression of the P2X(2) receptor subunit of the ATP-gated ion channel in the cochlea: implications for sound transduction and auditory neurotransmission by Housley, G D, Kanjhan, R, Raybould, N P, Greenwood, D, Salih, S G, Järlebark, L, Burton, L D, Setz, V C, Cannell, M B, Soeller, C, Christie, D L, Usami, S, Matsubara, A, Yoshie, H, Ryan, A F, Thorne, P R

“…Extracellular ATP has multimodal actions in the cochlea affecting hearing sensitivity. ATP-gated ion channels involved in this process were characterized in…”
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Cholinergic and purinergic signalling in outer hair cells of mammalian cochlea by Heilbronn, Edith, Järlebark, Leif, Lawoko, Grace

“…Outer (OHC) and inner (IHC) hair cells in the organ of Corti of the mammalian cochlea process sound. OHC and their efferent synapse are part of a feedback…”
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Molecular analyses of KCNQ1-5 potassium channel mRNAs in rat and guinea pig inner ears: expression, cloning, and alternative splicing by Liang, Gui-Hua, Jin, Zhe, Ulfendahl, Mats, Järlebark, Leif

“…Conclusion: Expression of neuronal Kcnq gene family transcripts in the inner ear provides further evidence for cochlear M-type currents and for complex…”
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Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea by Jin, Zhe, Liang, Gui-Hua, Cooper, Edward C, Jarlebark, Leif

“…KCNQ1 and KCNQ4 voltage-gated potassium channel subunits play key roles in hearing. Other members of the KCNQ family also encode slow, low voltage-activated…”
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Purinergic regulation of sound transduction and auditory neurotransmission by Housley, G D, Jagger, D J, Greenwood, D, Raybould, N P, Salih, S G, Järlebark, L E, Vlajkovic, S M, Kanjhan, R, Nikolic, P, Muñoz, D J M, Thorne, P R

“…In the cochlea, extracellular ATP influences the endocochlear potential, micromechanics, and neurotransmission via P2 receptors. Evidence for this arises from…”
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Tetrahydroaminoacridine and related compounds interfere with fura-2 and indo-1 by Järlebark, L, Heilbronn, E

“…In earlier experiments, using a fluorimetric method (fura-2), we found what seemed to be a decreased cytoplasmic [Ca2+] in neuroblastoma cells when…”
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Immunohistochemical localization of adenosine 5'-triphosphate-gated ion channel P2X(2) receptor subunits in adult and developing rat cochlea by Järlebark, L E, Housley, G D, Thorne, P R

“…Substantial in vitro and in vivo data support a role for extracellular adenosine 5;-triphosphate (ATP) and associated P2 receptors in cochlear function…”
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An M-like potassium current in the guinea pig cochlea by Liang, Guihua, Moore, Ernest J, Ulfendahl, Mats, Rydqvist, Bo, Järlebark, Leif

“…Potassium M currents play a role in stabilizing the resting membrane potential. These currents have previously been identified in several cell types, including…”
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Peptidyl Conjugates of Adenosine 5′-Carboxylic Acid Synthesized and Evaluated as Ligands for P2 Purinoceptors by Järlebark, Leif, Erlandsson, Mikael, Uri, Asko, King, Brian F., Ziganshin, Airat U., Johansson, Charlotta, Heilbronn, Edith

“…The role of extracellular ATPin vivoand the various cellular responses mediated by P2 purinoceptors have not yet been fully elucidated, in part depending on…”
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P2X2 receptor expression by interstitial cells of Cajal in vas deferens implicated in semen emission by BURTON, Lucille D, HOUSLEY, Gary D, SALIH, Salam G, JÄRLEBARK, Leif, CHRISTIE, David L, GREENWOOD, Denise

“…Male reproduction is dependent upon seminal emission mediated by vas deferens contraction. This drives spermatic fluid to the prostatic urethra during…”
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5-Substituted UTP derivatives as P2Y2 receptor agonists by KNOBLAUCH, B. H. A, MÜLLER, C. E, JÄRLEBARK, L, LAWOKO, G, KOTTKE, T, WIKSTRÖM, M. A, HEILBRONN, E

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Survival, synaptogenesis, and regeneration of adult mouse spiral ganglion in vitro by Wei, D, Jin, Z, Jarlebark, L, Scarfone, E, Ulfendahl, M

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Spatiotemporal loss of K+ transport proteins in the developing cochlear lateral wall of guinea pigs with hereditary deafness by Jin, Zhe, Ulfendahl, Mats, Järlebark, Leif

“…Genetic deafness is one of the most common human genetic birth defects. To understand the molecular mechanisms underlying human hereditary deafness, deaf…”
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Survival, synaptogenesis, and regeneration of adult mouse spiral ganglion neurons in vitro by Wei, Dongguang, Jin, Zhe, Järlebark, Leif, Scarfone, Eric, Ulfendahl, Mats

“…The inner ear spiral ganglion is populated by bipolar neurons connecting the peripheral sensory receptors, the hair cells, with central neurons in auditory…”
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Activation of JNK in the inner ear following impulse noise exposure by Murai, Norihiko, Kirkegaard, Mette, Järlebark, Leif, Risling, Mårten, Suneson, Anders, Ulfendahl, Mats

“…Noise exposure is known to induce cell death signaling in the cochlea. Since c-Jun N-terminal kinase (JNK) signaling is known to induce both cell survival and…”
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