Search Results - "Jäckel, Christian"

Protein design by directed evolution by Jäckel, Christian, Kast, Peter, Hilvert, Donald

“…While nature evolved polypeptides over billions of years, protein design by evolutionary mimicry is progressing at a far more rapid pace. The mutation,…”
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Fluorine in a Native Protein Environment-How the Spatial Demand and Polarity of Fluoroalkyl Groups Affect Protein Folding by Jäckel, Christian, Salwiczek, Mario, Koksch, Beate

“…Give and take: The influence of fluoro substitution of amino acid side chains on their interaction profile in a native polypeptide environment was studied…”
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Fluorine in Peptide Design and Protein Engineering by Jäckel, Christian, Koksch, Beate

“…The use of fluorine has become well established in the analysis of protein structure and function, e.g. in tools such as 19F NMR spectroscopy. The application…”
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Identification, Characterization, and Application of a Recombinant Antigen for the Serological Investigation of Feline Hemotropic Mycoplasma Infections by Wolf-Jäckel, Godelind A., Jäckel, Christian, Museux, Kristina, Hoelzle, Katharina, Tasker, Séverine, Lutz, Hans, Hofmann-Lehmann, Regina

“…OA  Classifications Services CVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Towards identifying preferred interaction partners of fluorinated amino acids within the hydrophobic environment of a dimeric coiled coil peptide by Vagt, Toni, Nyakatura, Elisabeth, Salwiczek, Mario, Jäckel, Christian, Koksch, Beate

“…Phage display technology has been applied to screen for preferred interaction partners of fluoroalkyl-substituted amino acids from the pool of the 20 canonical…”
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In silico screening of 393 mutants facilitates enzyme engineering of amidase activity in CalB by Hediger, Martin R, De Vico, Luca, Rannes, Julie B, Jäckel, Christian, Besenmatter, Werner, Svendsen, Allan, Jensen, Jan H

“…Our previously presented method for high throughput computational screening of mutant activity (Hediger et al., 2012) is benchmarked against experimentally…”
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Biocatalysts by evolution by Jäckel, Christian, Hilvert, Donald

“…Proteins evolve by iterative cycles of mutation, selection and amplification. Analogous evolutionary strategies are being profitably exploited in the…”
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Consensus Protein Design without Phylogenetic Bias by Jäckel, Christian, Bloom, Jesse D., Kast, Peter, Arnold, Frances H., Hilvert, Donald

“…Consensus design is an appealing strategy for the stabilization of proteins. It exploits amino acid conservation in sets of homologous proteins to identify…”
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Evaluation of the Molecular Interactions of Fluorinated Amino Acids with Native Polypeptides by Jäckel, Christian, Seufert, Wolfgang, Thust, Sven, Koksch, Beate

“…One fluorine can make a difference. Investigation of the properties of fluorinated amino acids in a native‐polypeptide environment increases our ability to use…”
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Cover Picture: Fluorine in Peptide Design and Protein Engineering (Eur. J. Org. Chem. 21/2005) by Jäckel, Christian, Koksch, Beate

“…The cover picture shows the specific interaction domains (yellow: hydrophobic core; red and blue: charged functional groups in amino acid side chains) of an…”
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β/γ Motif to Mimic α-Helical Turns in Proteins by Rezaei Araghi, Raheleh, Jäckel, Christian, Cölfen, Helmut, Salwiczek, Mario, Völkel, Antje, Wagner, Sara C, Wieczorek, Sebastian, Baldauf, Carsten, Koksch, Beate

“…The combination of the properties of β‐ and γ‐amino acids produce extended artificial fragments that recreate the properties of a natural α‐helix. The…”
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Selection of a buried salt bridge by phage display by Vagt, Toni, Jäckel, Christian, Samsonov, Sergey, Teresa Pisabarro, M., Koksch, Beate

“…Using phage display technology, a stable coiled coil pair of novel primary structure was selected. A staggered salt bridge within the hydrophobic core allows…”
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Fluor in nativer Peptidumgebung - wie Raumanspruch und Polarität von Fluoralkylgruppen die Proteinfaltung beeinflussen by Jäckel, Christian, Salwiczek, Mario, Koksch, Beate

“…Konträr: Der Einfluss von Fluorsubstitutionen in der Seitenkette von Aminosäuren auf die molekularen Wechselwirkungen in einer nativen Polypeptidumgebung wurde…”
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In silico screening of 393 mutants facilitates enzyme engineering of amidase activity in CalB by Hediger, Martin R, De Vico, Luca, Rannes, Julie B, Jäckel, Christian, Besenmatter, Werner, Svendsen, Allan, Jensen, Jan H

“…Our previously presented method for high throughput computational screening of mutant activity (Hediger et al., arXiv:1203.2950) is benchmarked against…”
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