Search Results - "Jácome, Alexandre A."

A comprehensive framework for early-onset colorectal cancer research by Eng, Cathy, Jácome, Alexandre A, Agarwal, Rajiv, Hayat, Muhammad Hashim, Byndloss, Mariana X, Holowatyj, Andreana N, Bailey, Christina, Lieu, Christopher H

“…Sporadic colorectal cancer has traditionally been viewed as a malignancy of older individuals. However, as the global prevalence of the disease diagnosed in…”
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Role of immune checkpoint inhibitors in the treatment of colorectal cancer: focus on nivolumab by Jácome, Alexandre A, Eng, Cathy

“…: Metastatic colorectal cancer (mCRC) is a challenging disease, whose systemic therapy has traditionally been based on a generalized population of patients,…”
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Minimal Residual Disease in Colorectal Cancer: Are We Finding the Needle in a Haystack? by Jácome, Alexandre A, Johnson, Benny

“…Despite significant advances in the surgical and systemic therapy of colorectal cancer (CRC) in recent decades, recurrence rates remain high. Apart from…”
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Anal Cancer: Emerging Standards in a Rare Rare Disease by Eng, Cathy, Ciombor, Kristen K, Cho, May, Dorth, Jennifer A, Rajdev, Lakshmi N, Horowitz, David P, Gollub, Marc J, Jácome, Alexandre A, Lockney, Natalie A, Muldoon, Roberta L, Washington, Mary Kay, O'Brian, Brittany A, Benny, Amala, Lebeck Lee, Cody M, Benson, 3rd, Al B, Goodman, Karyn A, Morris, Van Karlyle

“…The social stigma surrounding an anal cancer diagnosis has traditionally prevented open discussions about this disease. However, as recent treatment options…”
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The Role of Immunotherapy in the Treatment of Anal Cancer and Future Strategies by Jácome, Alexandre A., Morris, Van Karlyle, Eng, Cathy

“…Opinion statement Despite being markedly sensitive to chemoradiotherapy, patients with locally advanced (T3-4 and/or node-positive) squamous cell carcinoma of…”
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Anal Cancer: Emerging Standards in a Rare Disease by Eng, Cathy, Ciombor, Kristen K., Cho, May, Dorth, Jennifer A., Rajdev, Lakshmi N., Horowitz, David P., Gollub, Marc J., Jácome, Alexandre A., Lockney, Natalie A., Muldoon, Roberta L., Washington, Mary Kay, O'Brian, Brittany A., Benny, Amala, Lebeck Lee, Cody M., Benson, Al B., Goodman, Karyn A., Morris, Van Karlyle

“…The social stigma surrounding an anal cancer diagnosis has traditionally prevented open discussions about this disease. However, as recent treatment options…”
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Development and Validation of a Novel Nomogram for Individualized Prediction of Survival in Cancer of Unknown Primary by Raghav, Kanwal, Hwang, Hyunsoo, Jácome, Alexandre A, Bhang, Eric, Willett, Anneleis, Huey, Ryan W, Dhillon, Nishat P, Modha, Jignesh, Smaglo, Brandon, Matamoros, Jr, Aurelio, Estrella, Jeannelyn S, Jao, Justin, Overman, Michael J, Wang, Xuemei, Greco, F Anthony, Loree, Jonathan M, Varadhachary, Gauri R

“…Prognostic uncertainty is a major challenge for cancer of unknown primary (CUP). Current models limit a meaningful patient-provider dialogue. We aimed to…”
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The prognostic impact of RAS on overall survival following liver resection in early versus late-onset colorectal cancer patients by Jácome, Alexandre A., Vreeland, Timothy J., Johnson, Benny, Kawaguchi, Yoshikuni, Wei, Steven H., Nancy You, Y., Vilar, Eduardo, Vauthey, Jean-Nicolas, Eng, Cathy

“…Background The impact of molecular aberrations on survival after resection of colorectal liver metastases (CLM) in patients with early-age-onset (EOCRC) versus…”
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Integrated clinico-molecular profiling of appendiceal adenocarcinoma reveals a unique grade-driven entity distinct from colorectal cancer by Raghav, Kanwal, Shen, John P., Jácome, Alexandre A., Guerra, Jennifer L., Scally, Christopher P., Taggart, Melissa W., Foo, Wai C., Matamoros, Aurelio, Shaw, Kenna R., Fournier, Keith, Overman, Michael J., Eng, Cathy

“…Background Appendiceal adenocarcinoma (AA) is an orphan disease with unique clinical attributes but often treated as colorectal cancer (CRC). Understanding key…”
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Personalized medicine in gastric cancer: Where are we and where are we going? by Jácome, Alexandre A, Coutinho, Anelisa K, Lima, Enaldo M, Andrade, Aline C, Dos Santos, José Sebastião

“…Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis…”
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Mixture and non-mixture cure fraction models based on the generalized modified Weibull distribution with an application to gastric cancer data by Martinez, Edson Z, Achcar, Jorge A, Jácome, Alexandre A.A, Santos, José S

“…Abstract The cure fraction models are usually used to model lifetime time data with long-term survivors. In the present article, we introduce a Bayesian…”
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Targeting KRAS in Pancreatic Ductal Adenocarcinoma: The Long Road to Cure by de Jesus, Victor Hugo Fonseca, Mathias-Machado, Maria Cecília, de Farias, João Paulo Fogacci, Aruquipa, Marcelo Porfirio Sunagua, Jácome, Alexandre A, Peixoto, Renata D’Alpino

“…Pancreatic ductal adenocarcinoma (PDAC) remains an important cause of cancer-related mortality, and it is expected to play an even bigger part in cancer burden…”
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Adjuvant therapy for gastric cancer:What have we learned since INT0116? by Jácome, Alexandre A, Sankarankutty, Ajith K, dos Santos, José Sebastião

“…Gastric cancer is one of the main cancer-related causes of death worldwide. The curative treatment of gastric cancer consists of tumor resection and…”
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Effect of Adding Bevacizumab to Chemotherapy on Pathologic Response to Preoperative Systemic Therapy for Resectable Colorectal Liver Metastases: A Systematic Review and Meta-analysis by Jácome, Alexandre A., Oliveira, Fernanda A., Lino, Flora, Lima, João Paulo S.N.

“…•Perioperative therapy for colorectal liver metastases (CLM) has unclear benefit.•Pathologic response (pR) to preoperative therapy is a strong prognostic…”
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Risk of Cancer in Inflammatory Bowel Disease and Pitfalls in Oncologic Therapy by Peixoto, Renata D., Ferreira, Artur R., Cleary, James M., Fogacci, João P., Vasconcelos, João P., Jácome, Alexandre A.

“…Background Inflammatory bowel disease (IBD), represented by ulcerative colitis and Crohn’s disease, is an idiopathic condition caused by a dysregulated immune…”
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Determinants of COVID-19 Mortality in Patients With Cancer From a Community Oncology Practice in Brazil by Ferrari, Bruno L, Ferreira, Carlos Gil, Menezes, Márcia, De Marchi, Pedro, Canedo, Jorge, Melo, Andréia Cristina de, Jácome, Alexandre A, Reinert, Tomás, Paes, Rafael Duarte, Sodré, Bárbara, Barrios, Carlos H, Dienstmann, Rodrigo

“…The COVID-19 pandemic remains a public health emergency of global concern. Determinants of mortality in the general population are now clear, but specific data…”
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Efficacy and Safety Associated With Immune Checkpoint Inhibitors in Unresectable Hepatocellular Carcinoma: A Meta-analysis by Jácome, Alexandre A, Castro, Ana Carolina G, Vasconcelos, João Paulo S, Silva, Maria Helena C R, Lessa, Marco Antônio O, Moraes, Eduardo D, Andrade, Aline C, Lima, Frederico M T, Farias, João Paulo F, Gil, Roberto A, Prolla, Gabriel, Garicochea, Bernardo

“…Immune checkpoint inhibitors (ICIs) have yielded conflicting results in hepatocellular carcinoma (HCC). The overall effect of ICIs compared with standard…”
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Outcomes with anti-EGFR monoclonal antibodies in metastatic and recurrent anal squamous cell carcinoma by Rogers, Jane E., Jácome, Alexandre A. A., Ohinata, Aki, Wolff, Robert, Morris, Van K., Johnson, Benny, Mehdizadeh, Amir, Rothschild, Nicole D., Ahmed, Shahab U., Guerra, Jennifer L., Eng, Cathy

“…Metastatic squamous cell carcinoma anal cancer (SCCA) is rare. Prospective data recommends front-line platinum doublet combinations and second-line…”
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Biomarkers in Anal Cancer: Current Status in Diagnosis, Disease Progression and Therapeutic Strategies by Mathias-Machado, Maria Cecília, Peixoto, Renata D'Alpino, Moniz, Camila Motta Venchiarutti, Jácome, Alexandre A

“…Squamous cell carcinoma of the anal canal (SCCA) is a rare neoplasm, but with rising incidence rates in the past few decades; it is etiologically linked with…”
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FOLFOXIRI Versus Doublet Regimens in Right-Sided Metastatic Colorectal Cancer: Focus on Subsequent Therapies and Impact on Overall Survival by Jácome, Alexandre A., Kee, Bryan, Fogelman, David, Dasari, Arvind, Shureiqi, Imad, Raghav, Kanwal, Morris, Van, Johnson, Benny, Overman, Michael, Wolff, Robert, Kopetz, Scott, Rogers, Jane, Ahmed, Shahab U., Mehdizadeh, Amir, Rothschild, Nicole, Eng, Cathy

“…It has been determined that right-sided metastatic colorectal cancer (mCRC) has a worse prognosis for overall survival (OS). Currently, there is no consensus…”
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