Search Results - "Izutani, Noriyuki"
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Comparative study of flux redistribution of metabolic pathway in glutamate production by two coryneform bacteria
Published in Metabolic engineering (01-03-2005)“…In amino acid production by coryneform bacteria, study on relationship between change in enzyme activities and production of a target amino acid is important…”
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Novel hyaluronic acid–methotrexate conjugates for osteoarthritis treatment
Published in Bioorganic & medicinal chemistry (01-07-2009)“…We designed HA-MTX conjugates for the treatment of osteoarthritis. The conjugates showed remarkable inhibition of human synovial cell proliferation stimulated…”
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Journal Article -
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Synthesis and optimization of hyaluronic acid–methotrexate conjugates to maximize benefit in the treatment of osteoarthritis
Published in Bioorganic & medicinal chemistry (01-02-2010)“…We found DK226 to be a candidate drug for the treatment of osteoarthritis. Among several hyaluronic acid and methotrexate conjugates, DK226 showed remarkable…”
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