Search Results - "Izpisúa Belmonte, J C"
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Expression of the homeobox Hox-4 genes and the specification of position in chick wing development
Published in Nature (London) (18-04-1991)“…The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application…”
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2
Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming
Published in Stem cells (Dayton, Ohio) (01-09-2016)“…Epigenetic reprogramming is a central process during mammalian germline development. Genome‐wide DNA demethylation in primordial germ cells (PGCs) is a…”
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3
Complete Meiosis from Human Induced Pluripotent Stem Cells
Published in Stem cells (Dayton, Ohio) (01-08-2011)“…Gamete failure‐derived infertility affects millions of people worldwide; for many patients, gamete donation by unrelated donors is the only available…”
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4
Treating primary immunodeficiencies with defects in NK cells: from stem cell therapy to gene editing
Published in Stem cell research & therapy (27-10-2020)“…Primary immunodeficiency diseases (PIDs) are rare diseases that are characterized by genetic mutations that damage immunological function, defense, or both…”
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Correction to: Treating primary immunodeficiencies with defects in NK cells: from stem cell therapy to gene editing
Published in Stem cell research & therapy (27-04-2021)“…An amendment to this paper has been published and can be accessed via the original article…”
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Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders
Published in Molecular psychiatry (01-09-2016)“…With an onset under the age of 3 years, autism spectrum disorders (ASDs) are now understood as diseases arising from pre- and/or early postnatal brain…”
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7
Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes
Published in Scientific reports (13-11-2015)“…Autologous chondrocyte implantation (ACI) depends on the quality and quantity of implanted cells and is hindered by the fact that chondrocytes cultured for…”
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Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish
Published in Oncogene (27-09-2012)“…Angiogenesis is essential for development and tumor progression. With the aim of identifying new compound inhibitors of the angiogenesis process, we used an…”
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Generation of human organs in pigs via interspecies blastocyst complementation
Published in Reproduction in domestic animals (01-10-2016)“…Contents More than eighteen years have passed since the first derivation of human embryonic stem cells (ESCs), but their clinical use is still met with several…”
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10
Disease Correction the iPSC Way: Advances in iPSC-Based Therapy
Published in Clinical pharmacology and therapeutics (01-05-2011)“…Pluripotent stem cells possess the capacity for self‐renewal and the ability to differentiate into all cell types of the three embryonic germ layers…”
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11
Pitx2 determines left-right asymmetry of internal organs in vertebrates
Published in Nature (London) (06-08-1998)“…The handedness of visceral organs is conserved among vertebrates and is regulated by asymmetric signals relayed by molecules such as Shh, Nodal and activin…”
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12
Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts
Published in Cold Spring Harbor Symposia on Quantitative Biology (2008)“…Human embryonic stem (hES) cells represent a potential source for cell replacement therapy of many degenerative diseases. Most frequently, hES cell lines are…”
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13
Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development
Published in Genes & development (15-02-1999)“…Pitx1 is a Bicoid-related homeodomain factor that exhibits preferential expression in the hindlimb, as well as expression in the developing anterior pituitary…”
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14
Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb
Published in Nature (London) (27-03-1997)“…Vertebrate limb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the previous establishment of the dorsoventral…”
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Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells
Published in Human gene therapy (01-01-2012)“…Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) offer great hope for in vitro modeling of Parkinson's disease (PD), as well as for…”
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16
Switching cell fate, ncRNAs coming to play
Published in Cell death & disease (01-01-2013)“…Cell fate decision is a critical step during physiological development when embryonic stem cells commit to either becoming adult stem cells or somatic cells…”
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Developmental expression of chick twist and its regulation during limb patterning
Published in The International journal of developmental biology (01-09-2001)“…We have isolated a chick Twist gene (cTwist) and examined its expression pattern during development by whole mount in situ hybridization. In early embryos,…”
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The mis-expression of posterior Hox-4 genes in talpid (ta3) mutant wings correlates with the absence of anteroposterior polarity
Published in Development (Cambridge) (01-04-1992)“…Developing chicken wings homozygous for the talpid (ta3/ta3) mutation are polydactylous and have defects in the establishment of their anteroposterior…”
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19
Molecular basis of left-right asymmetry
Published in Development, growth & differentiation (01-12-1999)“…In vertebrates visceral asymmetry is conserved along the left-right axis within the body. Only a small percentage of randomization (situs ambiguus), or…”
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Hox-4 genes and the morphogenesis of mammalian genitalia
Published in Genes & development (01-10-1991)“…We examined the temporal and spatial expression patterns of the homeo box HOX-4 complex genes during the morphogenesis of the genitalia of mice. The results…”
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