Search Results - "Izpisúa‐Belmonte, J. C."

Expression of the homeobox Hox-4 genes and the specification of position in chick wing development by Izpisua-Belmonte, J.C, Tickle, C, Dolle, P, Wolpert, L, Duboule, D

“…The chicken Hox-4 homeogenes, like those of the mouse, are coordinately expressed in partially overlapping domains during wing development. Local application…”
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Characterization of the Epigenetic Changes During Human Gonadal Primordial Germ Cells Reprogramming by Eguizabal, C., Herrera, L., De Oñate, L., Montserrat, N., Hajkova, P., Izpisua Belmonte, J. C.

“…Epigenetic reprogramming is a central process during mammalian germline development. Genome‐wide DNA demethylation in primordial germ cells (PGCs) is a…”
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Complete Meiosis from Human Induced Pluripotent Stem Cells by Eguizabal, C., Montserrat, N., Vassena, R., Barragan, M., Garreta, E., Garcia‐Quevedo, L., Vidal, F., Giorgetti, A., Veiga, A., Belmonte, J. C. Izpisua

“…Gamete failure‐derived infertility affects millions of people worldwide; for many patients, gamete donation by unrelated donors is the only available…”
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Treating primary immunodeficiencies with defects in NK cells: from stem cell therapy to gene editing by Eguizabal, C, Herrera, L, Inglés-Ferrándiz, M, Izpisua Belmonte, J C

“…Primary immunodeficiency diseases (PIDs) are rare diseases that are characterized by genetic mutations that damage immunological function, defense, or both…”
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Correction to: Treating primary immunodeficiencies with defects in NK cells: from stem cell therapy to gene editing by Eguizabal, C, Herrera, L, Inglés-Ferrándiz, M, Belmonte, J C Izpisua

“…An amendment to this paper has been published and can be accessed via the original article…”
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Olfactory stem cells reveal MOCOS as a new player in autism spectrum disorders by Féron, F, Gepner, B, Lacassagne, E, Stephan, D, Mesnage, B, Blanchard, M-P, Boulanger, N, Tardif, C, Devèze, A, Rousseau, S, Suzuki, K, Izpisua Belmonte, J C, Khrestchatisky, M, Nivet, E, Erard-Garcia, M

“…With an onset under the age of 3 years, autism spectrum disorders (ASDs) are now understood as diseases arising from pre- and/or early postnatal brain…”
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Activin A/BMP2 chimera AB235 drives efficient redifferentiation of long term cultured autologous chondrocytes by Jiménez, G., López-Ruiz, E., Kwiatkowski, W., Montañez, E., Arrebola, F., Carrillo, E., Gray, P. C., Belmonte, J. C. Izpisua, Choe, S., Perán, M., Marchal, J. A.

“…Autologous chondrocyte implantation (ACI) depends on the quality and quantity of implanted cells and is hindered by the fact that chondrocytes cultured for…”
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Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish by Camus, S, Quevedo, C, Menéndez, S, Paramonov, I, Stouten, P F W, Janssen, R A J, Rueb, S, He, S, Snaar-Jagalska, B E, Laricchia-Robbio, L, Izpisua Belmonte, J C

“…Angiogenesis is essential for development and tumor progression. With the aim of identifying new compound inhibitors of the angiogenesis process, we used an…”
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Generation of human organs in pigs via interspecies blastocyst complementation by Wu, J, Platero Luengo, A, Gil, MA, Suzuki, K, Cuello, C, Morales Valencia, M, Parrilla, I, Martinez, CA, Nohalez, A, Roca, J, Martinez, EA, Izpisua Belmonte, JC

“…Contents More than eighteen years have passed since the first derivation of human embryonic stem cells (ESCs), but their clinical use is still met with several…”
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Disease Correction the iPSC Way: Advances in iPSC-Based Therapy by Sancho‐Martinez, I, Li, M, Izpisua Belmonte, JC

“…Pluripotent stem cells possess the capacity for self‐renewal and the ability to differentiate into all cell types of the three embryonic germ layers…”
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Pitx2 determines left-right asymmetry of internal organs in vertebrates by Belmonte, Juan Carlos Izpisúa, Ryan, Aimee K, Blumberg, Bruce, Rodriguez-Esteban, Concepción, Yonei-Tamura, Sayuri, Tamura, Koji, Tsukui, Tohru, de la Peña, Jennifer, Sabbagh, Walid, Greenwald, Jason, Choe, Senyon, Norris, Dominic P, Robertson, Elizabeth J, Evans, Ronald M, Rosenfeld, Michael G

“…The handedness of visceral organs is conserved among vertebrates and is regulated by asymmetric signals relayed by molecules such as Shh, Nodal and activin…”
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Generation of cardiomyocytes from new human embryonic stem cell lines derived from poor-quality blastocysts by Raya, A, Rodríguez-Pizà, I, Arán, B, Consiglio, A, Barri, P N, Veiga, A, Izpisúa Belmonte, J C

“…Human embryonic stem (hES) cells represent a potential source for cell replacement therapy of many degenerative diseases. Most frequently, hES cell lines are…”
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Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development by Szeto, D P, Rodriguez-Esteban, C, Ryan, A K, O'Connell, S M, Liu, F, Kioussi, C, Gleiberman, A S, Izpisúa-Belmonte, J C, Rosenfeld, M G

“…Pitx1 is a Bicoid-related homeodomain factor that exhibits preferential expression in the hindlimb, as well as expression in the developing anterior pituitary…”
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Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb by Rodriguez-Esteban, Concepción, Schwabe, John W. R, Peña, Jennifer De La, Foys, Bryon, Eshelman, Brian, Belmonte, Juan Carlos Izpisúa

“…Vertebrate limb outgrowth requires a structure called the apical ectodermal ridge, formation of which follows the previous establishment of the dorsoventral…”
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Efficient generation of A9 midbrain dopaminergic neurons by lentiviral delivery of LMX1A in human embryonic stem cells and induced pluripotent stem cells by Sánchez-Danés, A, Consiglio, A, Richaud, Y, Rodríguez-Pizà, I, Dehay, B, Edel, M, Bové, J, Memo, M, Vila, M, Raya, A, Izpisua Belmonte, J C

“…Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) offer great hope for in vitro modeling of Parkinson's disease (PD), as well as for…”
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Switching cell fate, ncRNAs coming to play by Guan, D, Zhang, W, Zhang, W, Liu, G-H, Belmonte, J C Izpisua

“…Cell fate decision is a critical step during physiological development when embryonic stem cells commit to either becoming adult stem cells or somatic cells…”
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Developmental expression of chick twist and its regulation during limb patterning by Tavares, A T, Izpisúja-Belmonte, J C, Rodriguez-León, J

“…We have isolated a chick Twist gene (cTwist) and examined its expression pattern during development by whole mount in situ hybridization. In early embryos,…”
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The mis-expression of posterior Hox-4 genes in talpid (ta3) mutant wings correlates with the absence of anteroposterior polarity by IZPISUA-BELMONTE, J. C, EDE, D. A, TICKLE, C, DUBOULE, D

“…Developing chicken wings homozygous for the talpid (ta3/ta3) mutation are polydactylous and have defects in the establishment of their anteroposterior…”
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Molecular basis of left-right asymmetry by Tamura, K, Yonei-Tamura, S, Izpisúa Belmonte, J C

“…In vertebrates visceral asymmetry is conserved along the left-right axis within the body. Only a small percentage of randomization (situs ambiguus), or…”
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Hox-4 genes and the morphogenesis of mammalian genitalia by DOLLE, P, IZPISUA-BELMONTE, J.-C, BROWN, J. M, TICKLE, C, DUBOULE, D

“…We examined the temporal and spatial expression patterns of the homeo box HOX-4 complex genes during the morphogenesis of the genitalia of mice. The results…”
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