The role of hypoxia-induced factor in the regulation of oxygen homeostasis during reparative regeneration in compromised microcirculation

The aim of the present review is to find an answer to the clinically important question on the mechanisms regulating the activity of reparative regeneration in hypoxic conditions and potential ways to modify this process. In the recent studies, compensated hypoxia is characterized as a trigger for t...

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Bibliographic Details
Published in:	Alʹmanakh klinicheskoĭ medit͡s︡iny Vol. 45; no. 8; pp. 674 - 680
Main Authors:	Izmaylov, S. G., Beschastnov, V. V., Ryabkov, M. G., Leont'ev, A. E., Lukoyanychev, E. E., Bagryantsev, M. V., Orlinskaya, N. Yu
Format:	Journal Article
Language:	English
Published:	MONIKI 31-01-2018
Subjects:	compromised microcirculation hif-1α reparative regeneration
Online Access:	Get full text
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Summary:	The aim of the present review is to find an answer to the clinically important question on the mechanisms regulating the activity of reparative regeneration in hypoxic conditions and potential ways to modify this process. In the recent studies, compensated hypoxia is characterized as a trigger for the regeneration, with the central regulating factor being the member of the cytokine family, hypoxia-inducible factor-1 (HIF-1). Changes in the concentration of this protein modulates cell migration, angiogenesis and epithelialmesenchymal integration; it also stimulates the proliferation of endothelial cells and fibroblasts, playing a major role in the stimulation of wound healing, especially with compromised microcirculation, for example, diabetes mellitus.
ISSN:	2072-0505 2587-9294
DOI:	10.18786/2072-0505-2017-45-8-674-680