Search Results - "Izawa, Mineko"

Carbohydrate‐mediated cell adhesion in cancer metastasis and angiogenesis by Kannagi, Reiji, Izawa, Mineko, Koike, Tetsufumi, Miyazaki, Keiko, Kimura, Naoko

“…Malignant transformation is associated with abnormal glycosylation, resulting in the synthesis and expression of altered carbohydrate determinants including…”
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Altered expression of glycan genes in cancers induced by epigenetic silencing and tumor hypoxia: Clues in the ongoing search for new tumor markers by Kannagi, Reiji, Sakuma, Keiichiro, Miyazaki, Keiko, Lim, Khe‐Ti, Yusa, Akiko, Yin, Jun, Izawa, Mineko

“…(Cancer Sci 2010; 101: 586–593) The glycan molecules that preferentially appear in cancers are clinically utilized as serum tumor markers. The exact reason,…”
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Current relevance of incomplete synthesis and neo-synthesis for cancer-associated alteration of carbohydrate determinants—Hakomori's concepts revisited by Kannagi, Reiji, Yin, Jun, Miyazaki, Keiko, Izawa, Mineko

“…Incomplete synthesis and neo-synthesis are two major concepts for cancer-associated alterations of cell surface carbohydrate determinants, formulated by…”
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Distinct substrate specificities of human GlcNAc-6-sulfotransferases revealed by mass spectrometry–based sulfoglycomic analysis by Yu, Shin-Yi, Hsiao, Cheng-Te, Izawa, Mineko, Yusa, Akiko, Ishida, Hiroji, Nakamura, Shigeo, Yagi, Hirokazu, Kannagi, Reiji, Khoo, Kay-Hooi

“…Sulfated glycans are known to be involved in several glycan-mediated cell adhesion and recognition pathways. Our mRNA transcript analyses on the genes involved…”
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Colonic epithelial cells express specific ligands for mucosal macrophage immunosuppressive receptors siglec-7 and -9 by Miyazaki, Keiko, Sakuma, Keiichiro, Kawamura, Yuki I, Izawa, Mineko, Ohmori, Katsuyuki, Mitsuki, Motoaki, Yamaji, Toshiyuki, Hashimoto, Yasuhiro, Suzuki, Akemi, Saito, Yukio, Dohi, Taeko, Kannagi, Reiji

“…Immune cells are known to express specific recognition molecules for cell surface glycans. However, mechanisms involved in glycan-mediated cell-cell…”
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Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells by JUN YIN, HASHIMOTO, Ayako, LIN, Chun-Hung, SATO, Chihiro, KITAJIMA, Ken, KANNAGI, Reiji, IZAWA, Mineko, MIYAZAKI, Keiko, CHEN, Guo-Yun, TAKEMATSU, Hiromu, KOZUTSUMI, Yasunori, SUZUKI, Akemi, FURUHATA, Kimio, CHENG, Feng-Leng

“…Tumor hypoxia figures heavily in malignant progression by altering the intracellular glucose metabolism and inducing angiogenic factor production, thus,…”
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Human B-lymphocytes Express α2-6-Sialylated 6-Sulfo-N-acetyllactosamine Serving as a Preferred Ligand for CD22/Siglec-2 by Kimura, Naoko, Ohmori, Katsuyuki, Miyazaki, Keiko, Izawa, Mineko, Matsuzaki, Yuji, Yasuda, Yosuke, Takematsu, Hiromu, Kozutsumi, Yasunori, Moriyama, Akihiko, Kannagi, Reiji

“…CD22/Siglec-2, an important inhibitory co-receptor on B-lymphocytes, is known to recognize α2-6-sialylated glycan as a specific ligand. Here we propose that…”
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Epigenetic Silencing of the Sulfate Transporter Gene DTDST Induces Sialyl Lewisx Expression and Accelerates Proliferation of Colon Cancer Cells by YUSA, Akiko, MIYAZAKI, Keiko, KIMURA, Naoko, IZAWA, Mineko, KANNAGI, Reiji

“…Colon cancer cells express the carbohydrate determinant sialyl Lewis(x), while they exhibit markedly decreased the expression of its sulfated derivative,…”
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N-Acetylglucosamine 6-O-Sulfotransferase-1 Regulates Expression of L-Selectin Ligands and Lymphocyte Homing by Uchimura, Kenji, Kadomatsu, Kenji, El-Fasakhany, Fathy M., Singer, Mark S., Izawa, Mineko, Kannagi, Reiji, Takeda, Naoki, Rosen, Steven D., Muramatsu, Takashi

“…Lymphocyte homing is initiated by the binding of L-selectin on lymphocytes to its ligands on high endothelial venules (HEV). Sialyl 6-sulfo Lewis X is a major…”
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Identification of a Major Carbohydrate Capping Group of the L-selectin Ligand on High Endothelial Venules in Human Lymph Nodes as 6-Sulfo Sialyl Lewis X by Mitsuoka, Chikako, Sawada-Kasugai, Mikiko, Ando-Furui, Keiko, Izawa, Mineko, Nakanishi, Hayao, Nakamura, Shigeo, Ishida, Hideharu, Kiso, Makoto, Kannagi, Reiji

“…We investigated the molecular species of sulfated sialyl Lewis X determinants, the putative L-selectin ligand, expressed on high endothelial venules (HEV) in…”
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SLX(sialyl SSEA-1, sialyl Le(x)-i) by Kannagi, Reiji, Izawa, Mineko, Sakuma, Keiichiro

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SLX (sialyl SSEA-1, sialyl Le(x)-i) by Kannagi, Reiji, Izawa, Mineko, Koike, Tetsufumi

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Human B-lymphocytes Express alpha 2-6-Sialylated 6-Sulfo-N-acetyllactosamine Serving as a Preferred Ligand for CD22/Siglec-2 by Kimura, Naoko, Ohmori, Katsuyuki, Miyazaki, Keiko, Izawa, Mineko, Matsuzaki, Yuji, Yasuda, Yosuke, Takematsu, Hiromu, Kozutsumi, Yasunori, Moriyama, Akihiko, Kannagi, Reiji

“…CD22/Siglec-2, an important inhibitory co-receptor on B-lymphocytes, is known to recognize alpha 2-6-sialylated glycan as a specific ligand. Here we propose…”
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Loss of disialyl Lewis(a), the ligand for lymphocyte inhibitory receptor sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7) associated with increased sialyl Lewis(a) expression on human colon cancers by Miyazaki, Keiko, Ohmori, Katsuyuki, Izawa, Mineko, Koike, Tetsufumi, Kumamoto, Kensuke, Furukawa, Koichi, Ando, Takayuki, Kiso, Makoto, Yamaji, Toshiyuki, Hashimoto, Yasuhiro, Suzuki, Akemi, Yoshida, Aruto, Takeuchi, Makoto, Kannagi, Reiji

“…Expression of sialyl Lewis(a) is known to be increased in cancers of the digestive organs. The determinant serves as a ligand for E-selectin and mediates…”
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Regulation of mouse kidney tubular epithelial cell‐specific expression of core 2 GlcNAc transferase by Sekine, Michiko, Taya, Choji, Kikkawa, Yoshiaki, Yonekawa, Hiromichi, Takenaka, Masaru, Matsuoka, Yasuko, Imai, Enyu, Izawa, Mineko, Kannagi, Reiji, Suzuki, Akemi

“…A mouse gene, Gsl5, controls the expression of Galβ1–4(Fucα1–3)GlcNAcβ1–6(Galβ1–3)Gb4Cer and its precursor glycolipids in the kidney by regulating…”
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Clinical application of functional glycoproteomics - dissection of glycotopes carried by soluble CD44 variants in sera of patients with cancers by Lim, Khe-Ti, Miyazaki, Keiko, Kimura, Naoko, Izawa, Mineko, Kannagi, Reiji

“…We provide here an example of clinical application of functional glycoproteomics for cancer diagnosis. Sialyl Lewis a and sialyl Lewis x glycotopes, which are…”
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Clinical application of functional glycoproteomics -dissection of glycotopes carried by soluble CD44 variants in sera of patients with cancers : Glycomics Approach for Cancer Biomarker Discovery by LIM, Khe-Ti, MIYAZAKI, Keiko, KIMURA, Naoko, IZAWA, Mineko, KANNAGI, Reiji

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Sialylated and sulfated carbohydrate ligands for selectins and siglecs: involvement in traffic and homing of human memory T and B lymphocytes by Kannagi, Reiji, Ohmori, Katsuyuki, Chen, Guo-Yun, Miyazaki, Keiko, Izawa, Mineko, Sakuma, Keiichiro

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Human B-lymphocytes Express α2-6-Sialylated 6-Sulfo-N-acetyllactosamine Serving as a Preferred Ligand for CD22/Siglec-2 by Naoko Kimura, Katsuyuki Ohmori, Keiko Miyazaki, Mineko Izawa, Yuji Matsuzaki, Yosuke Yasuda, Hiromu Takematsu, Yasunori Kozutsumi, Akihiko Moriyama, Reiji Kannagi

“…CD22/Siglec-2, an important inhibitory co-receptor on B-lymphocytes, is known to recognize α2-6-sialylated glycan as a specific ligand. Here we propose that…”
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Human B-lymphocytes express alpha2-6-sialylated 6-sulfo-N-acetyllactosamine serving as a preferred ligand for CD22/Siglec-2 by Kimura, Naoko, Ohmori, Katsuyuki, Miyazaki, Keiko, Izawa, Mineko, Matsuzaki, Yuji, Yasuda, Yosuke, Takematsu, Hiromu, Kozutsumi, Yasunori, Moriyama, Akihiko, Kannagi, Reiji

“…CD22/Siglec-2, an important inhibitory co-receptor on B-lymphocytes, is known to recognize alpha2-6-sialylated glycan as a specific ligand. Here we propose…”
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