Search Results - "Izabela A. Rodenhuis-Zybert"

TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis by Aguilar-Briseño, José A., Upasani, Vinit, Ellen, Bram M. ter, Moser, Jill, Pauzuolis, Mindaugas, Ruiz-Silva, Mariana, Heng, Sothy, Laurent, Denis, Choeung, Rithy, Dussart, Philippe, Cantaert, Tineke, Smit, Jolanda M., Rodenhuis-Zybert, Izabela A.

“…Vascular permeability and plasma leakage are immune-pathologies of severe dengue virus (DENV) infection, but the mechanisms underlying the exacerbated…”
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Tomatidine reduces Chikungunya virus progeny release by controlling viral protein expression by Troost-Kind, Berit, van Hemert, Martijn J, van de Pol, Denise, van der Ende-Metselaar, Heidi, Merits, Andres, Borggrewe, Malte, Rodenhuis-Zybert, Izabela A, Smit, Jolanda M

“…Tomatidine, a natural steroidal alkaloid from unripe green tomatoes has been shown to exhibit many health benefits. We recently provided in vitro evidence that…”
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TLR2 axis on peripheral blood mononuclear cells regulates inflammatory responses to non-infectious immature dengue virus particles by Aguilar Briseño, José Alberto, Ramos Pereira, Lennon, van der Laan, Marleen, Pauzuolis, Mindaugas, ter Ellen, Bram M, Upasani, Vinit, Moser, Jill, de Souza Ferreira, Luís Carlos, Smit, Jolanda M, Rodenhuis-Zybert, Izabela A

“…Severe dengue virus (DENV) infection is characterized by exacerbated inflammatory responses that lead to endothelial dysfunction and plasma leakage. We have…”
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Regulation of innate immune responses in macrophages differentiated in the presence of vitamin D and infected with dengue virus 2 by Castillo, Jorge Andrés, Giraldo, Diana M, Hernandez, Juan C, Smit, Jolanda M, Rodenhuis-Zybert, Izabela A, Urcuqui-Inchima, Silvio

“…A dysregulated or exacerbated inflammatory response is thought to be the key driver of the pathogenesis of severe disease caused by the mosquito-borne dengue…”
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Tomatidine, a natural steroidal alkaloid shows antiviral activity towards chikungunya virus in vitro by Troost, Berit, Mulder, Lianne M., Diosa-Toro, Mayra, van de Pol, Denise, Rodenhuis-Zybert, Izabela A., Smit, Jolanda M.

“…In recent decades, chikungunya virus (CHIKV) has re-emerged, leading to outbreaks of chikungunya fever in Africa, Asia and Central and South America. The…”
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Circulating adipokine levels and COVID-19 severity in hospitalized patients by Flikweert, Antine W., Kobold, Anneke C. Muller, van der Sar-van der Brugge, Simone, Heeringa, Peter, Rodenhuis-Zybert, Izabela A., Bijzet, Johan, Tami, Adriana, van der Gun, Bernardina T. F., Wold, Karin I., Huckriede, Anke, Franke, Hildegard, Emmen, Judith M. A., Emous, Marloes, Grootenboers, Marco J. J. H., van Meurs, Matijs, van der Voort, Peter H. J., Moser, Jill

“…Background Obesity is a risk factor for adverse outcomes in COVID-19, potentially driven by chronic inflammatory state due to dysregulated secretion of…”
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Resveratrol and Pterostilbene Inhibit SARS-CoV-2 Replication in Air–Liquid Interface Cultured Human Primary Bronchial Epithelial Cells by ter Ellen, Bram M., Dinesh Kumar, Nilima, Bouma, Ellen M., Troost, Berit, van de Pol, Denise P.I., van der Ende-Metselaar, Heidi H., Apperloo, Leonie, van Gosliga, Djoke, van den Berge, Maarten, Nawijn, Martijn C., van der Voort, Peter H.J., Moser, Jill, Rodenhuis-Zybert, Izabela A., Smit, Jolanda M.

“…The current COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has an enormous impact on human health and economy…”
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Immature dengue virus: a veiled pathogen? by Rodenhuis-Zybert, Izabela A, van der Schaar, Hilde M, da Silva Voorham, Júlia M, van der Ende-Metselaar, Heidi, Lei, Huan-Yao, Wilschut, Jan, Smit, Jolanda M

“…Cells infected with dengue virus release a high proportion of immature prM-containing virions. In accordance, substantial levels of prM antibodies are found in…”
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Direct Infection of B Cells by Dengue Virus Modulates B Cell Responses in a Cambodian Pediatric Cohort by Upasani, Vinit, Vo, Hoa Thi My, Auerswald, Heidi, Laurent, Denis, Heng, Sothy, Duong, Veasna, Rodenhuis-Zybert, Izabela A, Dussart, Philippe, Cantaert, Tineke

“…Dengue is an acute viral disease caused by dengue virus (DENV), which is transmitted by mosquitoes. Symptoms of DENV infection range from inapparent to severe…”
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Interleukin 27, like interferons, activates JAK-STAT signaling and promotes pro-inflammatory and antiviral states that interfere with dengue and chikungunya viruses replication in human macrophages by Valdés-López, Juan Felipe, Hernández-Sarmiento, Lady Johana, Tamayo-Molina, Y S, Velilla-Hernández, Paula A, Rodenhuis-Zybert, Izabela A, Urcuqui-Inchima, Silvio

“…Interferons (IFNs) are a family of cytokines that activate the JAK-STAT signaling pathway to induce an antiviral state in cells. Interleukin 27 (IL-27) is a…”
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Chikungunya virus requires an intact microtubule network for efficient viral genome delivery by Hoornweg, Tabitha E, Bouma, Ellen M, van de Pol, Denise P.I, Rodenhuis-Zybert, Izabela A, Smit, Jolanda M

“…Chikungunya virus (CHIKV) is a re-emerging mosquito-borne alphavirus, which has rapidly spread around the globe thereby causing millions of infections. CHIKV…”
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Impaired Antibody-Independent Immune Response of B Cells in Patients With Acute Dengue Infection by Upasani, Vinit, Vo, Hoa Thi My, Ung, Sivlin, Heng, Sothy, Laurent, Denis, Choeung, Rithy, Duong, Veasna, Sorn, Sopheak, Ly, Sowath, Rodenhuis-Zybert, Izabela A, Dussart, Philippe, Cantaert, Tineke

“…Dengue is a mosquito-borne viral disease caused by dengue virus (DENV). The disease is endemic to more than 100 countries with 390 million dengue infections…”
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Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro by ter Ellen, Bram M., Niewold, Jelmer, Flikweert, Antine, Muller Kobold, Anneke C., Heeringa, Peter, van Meurs, Matijs, Smit, Jolanda M., van der Voort, Peter H. J., Rodenhuis-Zybert, Izabela A., Moser, Jill

“…Clinical observations have shown that obesity is associated with the severe outcome of SARS-CoV-2 infection hallmarked by microvascular dysfunction in the…”
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A Fusion-Loop Antibody Enhances the Infectious Properties of Immature Flavivirus Particles by Rodenhuis-Zybert, Izabela A, Moesker, Bastiaan, da Silva Voorham, Júlia M, van der Ende-Metselaar, Heidi, Diamond, Michael S, Wilschut, Jan, Smit, Jolanda M

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Suppression of chikungunya virus replication and differential innate responses of human peripheral blood mononuclear cells during co-infection with dengue virus by Ruiz Silva, Mariana, Aguilar Briseño, José A, Upasani, Vinit, van der Ende-Metselaar, Heidi, Smit, Jolanda M, Rodenhuis-Zybert, Izabela A

“…Dengue and chikungunya are viral diseases transmitted to humans by infected Aedes spp. mosquitoes. With an estimated 390 million infected people per year…”
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Immature dengue virus is infectious in human immature dendritic cells via interaction with the receptor molecule DC-SIGN by Richter, Mareike K S, da Silva Voorham, Júlia M, Torres Pedraza, Silvia, Hoornweg, Tabitha E, van de Pol, Denise P I, Rodenhuis-Zybert, Izabela A, Wilschut, Jan, Smit, Jolanda M

“…Dengue Virus (DENV) is the most common mosquito-borne viral infection worldwide. Important target cells during DENV infection are macrophages, monocytes, and…”
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Characterization of soluble TLR2 and CD14 levels during acute dengue virus infection by Upasani, Vinit, ter Ellen, Bram M., Sann, Sotheary, Lay, Sokchea, Heng, Sothy, Laurent, Denis, Ly, Sowath, Duong, Veasna, Dussart, Philippe, Smit, Jolanda M., Cantaert, Tineke, Rodenhuis-Zybert, Izabela A.

“…Dengue virus infection results in a broad spectrum of diseases ranging from mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF) and dengue shock…”
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Antibodies against the envelope glycoprotein promote infectivity of immature dengue virus serotype 2 by da Silva Voorham, Júlia M, Rodenhuis-Zybert, Izabela A, Ayala Nuñez, Nilda Vanesa, Colpitts, Tonya M, van der Ende-Metselaar, Heidi, Fikrig, Erol, Diamond, Michael S, Wilschut, Jan, Smit, Jolanda M

“…Cross-reactive dengue virus (DENV) antibodies directed against the envelope (E) and precursor membrane (prM) proteins are believed to contribute to the…”
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Human macrophages differentiated in the presence of vitamin D3 restrict dengue virus infection and innate responses by downregulating mannose receptor expression by Arboleda Alzate, John F, Rodenhuis-Zybert, Izabela A, Hernández, Juan C, Smit, Jolanda M, Urcuqui-Inchima, Silvio

“…Severe dengue disease is associated with high viral loads and overproduction of pro-inflammatory cytokines, suggesting impairment in the control of dengue…”
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Dengue virus life cycle: viral and host factors modulating infectivity by Rodenhuis-Zybert, Izabela A, Wilschut, Jan, Smit, Jolanda M

“…Dengue virus (DENV 1-4) represents a major emerging arthropod-borne pathogen. All four DENV serotypes are prevalent in the (sub) tropical regions of the world…”
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