Search Results - "Iyer, Shyam R."

O 2 Activation by Nonheme Fe II α-Ketoglutarate-Dependent Enzyme Variants: Elucidating the Role of the Facial Triad Carboxylate in FIH by Iyer, Shyam R, Chaplin, Vanessa D, Knapp, Michael J, Solomon, Edward I

“…FIH [factor inhibiting HIF (hypoxia inducible factor)] is an α-ketoglutarate (αKG)-dependent nonheme iron enzyme that catalyzes the hydroxylation of the…”
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Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad FeIVO Intermediate in Taurine Dioxygenase: Evaluation of Structural Contributions to Hydrogen Atom Abstraction by Srnec, Martin, Iyer, Shyam R, Dassama, Laura M. K, Park, Kiyoung, Wong, Shaun D, Sutherlin, Kyle D, Yoda, Yoshitaka, Kobayashi, Yasuhiro, Kurokuzu, Masayuki, Saito, Makina, Seto, Makoto, Krebs, Carsten, Bollinger, J. Martin, Solomon, Edward I

“…The α-ketoglutarate (αKG)-dependent oxygenases catalyze a diverse range of chemical reactions using a common high-spin FeIVO intermediate that, in most…”
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Evaluation of a concerted vs. sequential oxygen activation mechanism in α-ketoglutarate–dependent nonheme ferrous enzymes by Goudarzi, Serra, Iyer, Shyam R., Babicz, Jeffrey T., Yan, James J., Peters, Günther H. J., Christensen, Hans E. M., Hedman, Britt, Hodgson, Keith O., Solomon, Edward I.

“…Determining the requirements for efficient oxygen (O₂) activation is key to understanding how enzymes maintain efficacy and mitigate unproductive, often…”
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Direct coordination of pterin to Fe II enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases by Iyer, Shyam R, Tidemand, Kasper D, Babicz, Jr, Jeffrey T, Jacobs, Ariel B, Gee, Leland B, Haahr, Lærke T, Yoda, Yoshitaka, Kurokuzu, Masayuki, Kitao, Shinji, Saito, Makina, Seto, Makoto, Christensen, Hans E M, Peters, Günther H J, Solomon, Edward I

“…The pterin-dependent nonheme iron enzymes hydroxylate aromatic amino acids to perform the biosynthesis of neurotransmitters to maintain proper brain function…”
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O2 Activation by Nonheme FeII α‑Ketoglutarate-Dependent Enzyme Variants: Elucidating the Role of the Facial Triad Carboxylate in FIH by Iyer, Shyam R, Chaplin, Vanessa D, Knapp, Michael J, Solomon, Edward I

“…FIH [factor inhibiting HIF (hypoxia inducible factor)] is an α-ketoglutarate (αKG)-dependent nonheme iron enzyme that catalyzes the hydroxylation of the…”
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Nuclear Resonance Vibrational Spectroscopic Definition of the Facial Triad Fe IV ═O Intermediate in Taurine Dioxygenase: Evaluation of Structural Contributions to Hydrogen Atom Abstraction by Srnec, Martin, Iyer, Shyam R, Dassama, Laura M K, Park, Kiyoung, Wong, Shaun D, Sutherlin, Kyle D, Yoda, Yoshitaka, Kobayashi, Yasuhiro, Kurokuzu, Masayuki, Saito, Makina, Seto, Makoto, Krebs, Carsten, Bollinger, Jr, J Martin, Solomon, Edward I

“…The α-ketoglutarate (αKG)-dependent oxygenases catalyze a diverse range of chemical reactions using a common high-spin Fe ═O intermediate that, in most…”
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Direct coordination of pterin to FeII enables neurotransmitter biosynthesis in the pterin-dependent hydroxylases by Iyer, Shyam R., Tidemand, Kasper D., Babicz, Jeffrey T., Jacobs, Ariel B., Gee, Leland B., Haahr, Lærke T., Yoda, Yoshitaka, Kurokuzu, Masayuki, Kitao, Shinji, Saito, Makina, Seto, Makoto, Christensen, Hans E. M., Peters, Günther H. J., Solomon, Edward I.

“…The pterin-dependent nonheme iron enzymes hydroxylate aromatic amino acids to perform the biosynthesis of neurotransmitters to maintain proper brain function…”
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A chameleon catalyst for nonheme iron-promoted olefin oxidation by Iyer, Shyam R, Javadi, Maedeh Moshref, Feng, Yan, Hyun, Min Young, Oloo, Williamson N, Kim, Cheal, Que, Jr, Lawrence

“…We report the chameleonic reactivity of two nonheme iron catalysts for olefin oxidation with H2O2 that switch from nearly exclusive cis-dihydroxylation of…”
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NRVS Definition of the Facial Triad FeIV=O Intermediate in Taurine Dioxygenase: Evaluation of Structural Contributions to Hydrogen Atom Abstraction by Srnec, Martin, Iyer, Shyam R., Dassama, Laura M. K., Park, Kiyoung, Wong, Shaun D., Sutherlin, Kyle D., Yoda, Yoshitaka, Kobayashi, Yasuhiro, Kurokuzu, Masayuki, Saito, Makina, Seto, Makoto, Krebs, Carsten, Bollinger, J. Martin, Solomon, Edward I.

“…The α-ketoglutarate (αKG)-dependent oxygenases catalyze a diverse range of chemical reactions using a common high-spin Fe IV =O intermediate and, in most…”
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