Search Results - "Iyer, Shama R."

The Neuromuscular Junction: Roles in Aging and Neuromuscular Disease by Iyer, Shama R, Shah, Sameer B, Lovering, Richard M

“…The neuromuscular junction (NMJ) is a specialized synapse that bridges the motor neuron and the skeletal muscle fiber and is crucial for conversion of…”
Get full text

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation by Ryu, Dongryeol, Zhang, Hongbo, Ropelle, Eduardo R, Sorrentino, Vincenzo, Mázala, Davi A G, Mouchiroud, Laurent, Marshall, Philip L, Campbell, Matthew D, Ali, Amir Safi, Knowels, Gary M, Bellemin, Stéphanie, Iyer, Shama R, Wang, Xu, Gariani, Karim, Sauve, Anthony A, Cantó, Carles, Conley, Kevin E, Walter, Ludivine, Lovering, Richard M, Chin, Eva R, Jasmin, Bernard J, Marcinek, David J, Menzies, Keir J, Auwerx, Johan

“…Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of…”
Get more information

Fatty Infiltration Is a Prognostic Marker of Muscle Function After Rotator Cuff Tear by Valencia, Ana P., Lai, Jim K., Iyer, Shama R., Mistretta, Katherine L., Spangenburg, Espen E., Davis, Derik L., Lovering, Richard M., Gilotra, Mohit N.

“…Background: Massive rotator cuff tears (RCTs) begin as primary tendon injuries and cause a myriad of changes in the muscle, including atrophy, fatty…”
Get full text

Defective signaling, osteoblastogenesis and bone remodeling in a mouse model of connexin 43 C-terminal truncation by Moorer, Megan C, Hebert, Carla, Tomlinson, Ryan E, Iyer, Shama R, Chason, Max, Stains, Joseph P

“…In skeletal tissue, loss or mutation of the gap junction protein connexin 43 (Cx43, also known as GJA1) in cells of the osteoblast lineage leads to a profound…”
Get full text

The Nucleoskeleton: Crossroad of Mechanotransduction in Skeletal Muscle by Iyer, Shama R, Folker, Eric S, Lovering, Richard M

“…Intermediate filaments (IFs) are a primary structural component of the cytoskeleton extending throughout the muscle cell (myofiber). Mechanotransduction, the…”
Get full text

Differential YAP nuclear signaling in healthy and dystrophic skeletal muscle by Iyer, Shama R, Shah, Sameer B, Ward, Christopher W, Stains, Joseph P, Spangenburg, Espen E, Folker, Eric S, Lovering, Richard M

“…Mechanical forces regulate muscle development, hypertrophy, and homeostasis. Force-transmitting structures allow mechanotransduction at the sarcolemma,…”
Get more information

Abnormalities in Brain and Muscle Microstructure and Neurochemistry of the DMD Rat Measured by in vivo Diffusion Tensor Imaging and High Resolution Localized 1H MRS by Xu, Su, Tang, Shiyu, Li, Xin, Iyer, Shama R., Lovering, Richard M.

“…Duchenne muscular dystrophy (DMD) is an X-linked disorder caused by lack of dystrophin with progressive degeneration of skeletal muscles. Most studies…”
Get full text

Impaired contractile function of the supraspinatus in the acute period following a rotator cuff tear by Valencia, Ana P, Iyer, Shama R, Spangenburg, Espen E, Gilotra, Mohit N, Lovering, Richard M

“…Rotator cuff (RTC) tears are a common clinical problem resulting in adverse changes to the muscle, but there is limited information comparing histopathology to…”
Get full text

Engineering functional and histological regeneration of vascularized skeletal muscle by Gilbert-Honick, Jordana, Iyer, Shama R., Somers, Sarah M., Lovering, Richard M., Wagner, Kathryn, Mao, Hai-Quan, Grayson, Warren L.

“…Tissue engineering strategies to treat patients with volumetric muscle loss (VML) aim to recover the structure and contractile function of lost muscle tissue…”
Get full text

Exosomes Isolated From Platelet-Rich Plasma and Mesenchymal Stem Cells Promote Recovery of Function After Muscle Injury by Iyer, Shama R., Scheiber, Amanda L., Yarowsky, Paul, Henn, R. Frank, Otsuru, Satoru, Lovering, Richard M.

“…Background: Clinical use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) has gained momentum as treatment for muscle injuries. Exosomes, or…”
Get full text

Alterations of neuromuscular junctions in Duchenne muscular dystrophy by Lovering, Richard M., Iyer, Shama R., Edwards, Benjamin, Davies, Kay E.

“…[Display omitted] •Duchenne muscular dystrophy (DMD), the most common form of muscular dystrophy, is caused by the lack of dystrophin, a protein encoded by the…”
Get full text

Muscle phenotype of a rat model of Duchenne muscular dystrophy by Iyer, Shama R., Xu, Su, Shah, Sameer B., Lovering, Richard M.

“…Introduction Our aim was to assess key muscle imaging and contractility parameters in the Duchenne muscular dystrophy (DMD) rat model (Dmd‐KO rat), which have…”
Get full text

Age-dependent changes in nuclear-cytoplasmic signaling in skeletal muscle by Iyer, Shama R., Hsia, Ru-Ching, Folker, Eric S., Lovering, Richard M.

“…Mechanical forces are conducted through myofibers and into nuclei to regulate muscle development, hypertrophy, and homeostasis. We hypothesized that nuclei in…”
Get full text

Chitosan selectively promotes adhesion of myoblasts over fibroblasts by Iyer, Shama R., Udpa, Natasha, Gao, Yingxin

“…Treatment of ventral hernias frequently makes use of synthetic and biological meshes, often resulting in scar tissue formation and incomplete muscle…”
Get full text

Non‐invasive assessment of muscle injury in healthy and dystrophic animals with electrical impedance myography by Sanchez, Benjamin, Iyer, Shama R., Li, Jia, Kapur, Kush, Xu, Su, Rutkove, Seward B., Lovering, Richard M.

“…ABSTRACT Introduction Dystrophic muscle is particularly susceptible to eccentric contraction–induced injury. We tested the hypothesis that electrical impedance…”
Get full text

Human pluripotent stem cell-derived myogenic progenitors undergo maturation to quiescent satellite cells upon engraftment by Sun, Congshan, Kannan, Suraj, Choi, In Young, Lim, HoTae, Zhang, Hao, Chen, Grace S, Zhang, Nancy, Park, Seong-Hyun, Serra, Carlo, Iyer, Shama R, Lloyd, Thomas E, Kwon, Chulan, Lovering, Richard M, Lim, Su Bin, Andersen, Peter, Wagner, Kathryn R, Lee, Gabsang

“…Human pluripotent stem cell (hPSC)-derived myogenic progenitor cell (MPC) transplantation is a promising therapeutic approach for a variety of degenerative…”
Get full text

Fibroadipogenic progenitor cell response peaks prior to progressive fatty infiltration after rotator cuff tendon tear by Sahai, Amil, Jones, Derek L., Hughes, Marcus, Pu, Alex, Williams, Katrina, Iyer, Shama R., Rathinam, Chozha, Davis, Derik L., Lovering, Richard M., Gilotra, Mohit N.

“…Fibroadipogenic progenitor (FAP) cells are implicated as a major source of fatty infiltration (FI) in murine rotator cuff (RC) injury, but FAP cell response…”
Get full text

Inhibition of YAP signaling improves recovery in injured skeletal muscle by Iyer, Shama R., Shah, Sameer B., Ward, Christopher W., Stains, Joseph P., Folker, Eric S., Lovering, Richard M.

“…Skeletal muscle experiences mechanical forces that regulate its development, hypertrophy, and homeostasis. YAP (Yes‐associated protein) not only serves as an…”
Get full text

Neuromuscular Regeneration of Volumetric Muscle Loss Injury in Response to Agrin‐Functionalized Tissue Engineered Muscle Grafts and Rehabilitative Exercise by Mihaly, Eszter, Chellu, Neha, Iyer, Shama R., Su, Eileen Y., Altamirano, Dallas E., Dias, Shaquielle T., Grayson, Warren L.

“…Abstract Neuromuscular deficits compound the loss of contractile tissue in volumetric muscle loss (VML). Two avenues for promoting recovery are neuromuscular…”
Get full text

Mss51 deletion increases endurance and ameliorates histopathology in the mdx mouse model of Duchenne muscular dystrophy by Rovira Gonzalez, Yazmin I., Moyer, Adam L., LeTexier, Nicolas J., Bratti, August D., Feng, Siyuan, Peña, Vanessa, Sun, Congshan, Pulcastro, Hannah, Liu, Ting, Iyer, Shama R., Lovering, Richard M., O'Rourke, Brian, Wagner, Kathryn R.

“…Mitochondrial derangement is an important contributor to the pathophysiology of muscular dystrophies and may be among the earliest cellular deficits. We have…”
Get full text