Search Results - "Iyer, S."

How colonization by microbiota in early life shapes the immune system by Gensollen, Thomas, Iyer, Shanker S., Kasper, Dennis L., Blumberg, Richard S.

“…Microbial colonization of mucosal tissues during infancy plays an instrumental role in the development and education of the host mammalian immune system. These…”
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A novel Zig-Zag scheme for power enhancement of partially shaded solar arrays by Vijayalekshmy, S., Bindu, G.R., Rama Iyer, S.

“…•A novel reconfiguration scheme is proposed for shade dispersion during partial shading.•The novel scheme is compared with the classical TCT scheme and optimal…”
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PHI-base in 2022: a multi-species phenotype database for Pathogen–Host Interactions by Urban, Martin, Cuzick, Alayne, Seager, James, Wood, Valerie, Rutherford, Kim, Venkatesh, Shilpa Yagwakote, Sahu, Jashobanta, Iyer, S Vijaylakshmi, Khamari, Lokanath, De Silva, Nishadi, Martinez, Manuel Carbajo, Pedro, Helder, Yates, Andrew D, Hammond-Kosack, Kim E

“…Abstract Since 2005, the Pathogen–Host Interactions Database (PHI-base) has manually curated experimentally verified pathogenicity, virulence and effector…”
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COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation by Kempuraj, Duraisamy, Selvakumar, Govindhasamy Pushpavathi, Ahmed, Mohammad Ejaz, Raikwar, Sudhanshu P., Thangavel, Ramasamy, Khan, Asher, Zaheer, Smita A., Iyer, Shankar S., Burton, Casey, James, Donald, Zaheer, Asgar

“…Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new pandemic infectious disease that originated…”
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Harnessing machine learning and virtual sample generation for corrosion studies of 2-alkyl benzimidazole scaffold small dataset with an experimental validation by Iyer, Ram S, Iyer, Narayan S, P, Rugmini Ammal, Joseph, Abraham

“…•Results of wet corrosion studies are predicted using AI methodologies.•Artificial neural network ML algorithm was used to mode the real systems.•Virtual…”
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Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation by Iyer, Shankar S., He, Qiong, Janczy, John R., Elliott, Eric I., Zhong, Zhenyu, Olivier, Alicia K., Sadler, Jeffrey J., Knepper-Adrian, Vickie, Han, Renzhi, Qiao, Liang, Eisenbarth, Stephanie C., Nauseef, William M., Cassel, Suzanne L., Sutterwala, Fayyaz S.

“…Nlrp3 inflammasome activation occurs in response to numerous agonists but the specific mechanism by which this takes place remains unclear. All previously…”
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Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction by Foster, Toshana L., Wilson, Harry, Iyer, Shilpa S., Coss, Karen, Doores, Katie, Smith, Sarah, Kellam, Paul, Finzi, Andrés, Borrow, Persephone, Hahn, Beatrice H., Neil, Stuart J.D.

“…Interferon-induced transmembrane proteins (IFITMs) restrict the entry of diverse enveloped viruses through incompletely understood mechanisms. While IFITMs are…”
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Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis by Iyer, Neel S., Balsamo, Lyn M., Bracken, Michael B., Kadan-Lottick, Nina S.

“…Therapy for childhood acute lymphoblastic leukemia (ALL) is associated with 5-year survival rates of ∼90% even after largely eliminating cranial radiation…”
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Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma by Kempuraj, Duraisamy, Thangavel, Ramasamy, Kempuraj, Deepak D., Ahmed, Mohammad Ejaz, Selvakumar, Govindhasamy Pushpavathi, Raikwar, Sudhanshu P., Zaheer, Smita A., Iyer, Shankar S., Govindarajan, Raghav, Chandrasekaran, Premkumar Nattanmai, Zaheer, Asgar

“…Neuroinflammation leads to neurodegeneration, cognitive defects, and neurodegenerative disorders. Neurotrauma/traumatic brain injury (TBI) can cause activation…”
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Biomass‐derived porous carbon and colour‐tunable graphene quantum dots for high‐performance supercapacitor and selective probe for metal ion detection by Iyer, Maalavika, Rajangam, Ilangovan

“…Summary The abundance of biomass waste and their alteration into carbon‐based electrodes grants practical application of the same. The present work describes…”
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Pharmacovigilance Using Clinical Notes by LePendu, P, Iyer, S V, Bauer-Mehren, A, Harpaz, R, Mortensen, J M, Podchiyska, T, Ferris, T A, Shah, N H

“…With increasing adoption of electronic health records (EHRs), there is an opportunity to use the free‐text portion of EHRs for pharmacovigilance. We present…”
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A role for the gibberellin pathway in biochar-mediated growth promotion by French, Elizabeth, Iyer-Pascuzzi, Anjali S.

“…Biochar is a carbon negative soil amendment that can promote crop growth. However, the effects of biochar on different plant species and cultivars within a…”
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Impact of palbociclib plus letrozole on patient-reported health-related quality of life: results from the PALOMA-2 trial by Rugo, H.S., Diéras, V., Gelmon, K.A., Finn, R.S., Slamon, D.J., Martin, M., Neven, P., Shparyk, Y., Mori, A., Lu, D.R., Bhattacharyya, H., Bartlett, C.H.u.a.n.g., Iyer, S., Johnston, S., Ettl, J., Harbeck, N.

“…Patient-reported outcomes are integral in benefit–risk assessments of new treatment regimens. The PALOMA-2 study provides the largest body of evidence for…”
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Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS by Ma, Feng, Li, Bing, Liu, Su-yang, Iyer, Shankar S, Yu, Yongxin, Wu, Aiping, Cheng, Genhong

“…Rapid and robust induction of type I IFN (IFN-I) is a critical event in host antiviral innate immune response. It has been well demonstrated that cyclic…”
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Palbociclib plus letrozole as first-line therapy in estrogen receptor-positive/human epidermal growth factor receptor 2-negative advanced breast cancer with extended follow-up by Rugo, H. S., Finn, R. S., Diéras, V., Ettl, J., Lipatov, O., Joy, A. A., Harbeck, N., Castrellon, A., Iyer, S., Lu, D. R., Mori, A., Gauthier, E. R., Bartlett, C. Huang, Gelmon, K. A., Slamon, D. J.

“…Purpose In the initial PALOMA-2 (NCT01740427) analysis with median follow-up of 23 months, palbociclib plus letrozole significantly prolonged progression-free…”
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Silicon-Interconnect Fabric for Fine-Pitch (≤10 μm) Heterogeneous Integration by Jangam, SivaChandra, Iyer, Subramanian S.

“…The apparent saturation of aggressive Moore's law scaling of semiconductor technologies is pushing the boundaries of traditional packaging and integration…”
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Loss of Junctional Adhesion Molecule A Promotes Severe Steatohepatitis in Mice on a Diet High in Saturated Fat, Fructose, and Cholesterol by Rahman, Khalidur, Desai, Chirayu, Iyer, Smita S, Thorn, Natalie E, Kumar, Pradeep, Liu, Yunshan, Smith, Tekla, Neish, Andrew S, Li, Hongliang, Tan, Shiyun, Wu, Pengbo, Liu, Xiaoxiong, Yu, Yuanjie, Farris, Alton B, Nusrat, Asma, Parkos, Charles A, Anania, Frank A

“…Background & Aims There is evidence from clinical studies that compromised intestinal epithelial permeability contributes to the development of nonalcoholic…”
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Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection by Hale, J. Scott, Youngblood, Ben, Latner, Donald R., Mohammed, Ata Ur Rasheed, Ye, Lilin, Akondy, Rama S., Wu, Tuoqi, Iyer, Smita S., Ahmed, Rafi

“…CD4+ T follicular helper (Tfh) cells provide the required signals to B cells for germinal center reactions that are necessary for long-lived antibody…”
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COVID-19 Implications on Clinical Clerkships and the Residency Application Process for Medical Students by Akers, Allison, Blough, Christian, Iyer, Maya S

“…The coronavirus disease 2019 (COVID-19) pandemic has caused significant disruption to undergraduate medical education (UME). Although the immediate scheduling…”
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Highly effective combination of LSD1 (KDM1A) antagonist and pan-histone deacetylase inhibitor against human AML cells by Fiskus, W, Sharma, S, Shah, B, Portier, B P, Devaraj, S G T, Liu, K, Iyer, S P, Bearss, D, Bhalla, K N

“…The histone demethylase LSD1 (KDM1A) demethylates mono- and di-methylated (Me2) lysine (K) 4 on histone H3. High LSD1 expression blocks differentiation and…”
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