Search Results - "Iyer, Rohin K"

Influence of substrate stiffness on the phenotype of heart cells by Bhana, Bashir, Iyer, Rohin K, Chen, Wen Li Kelly, Zhao, Ruogang, Sider, Krista L, Likhitpanichkul, Morakot, Simmons, Craig A, Radisic, Milica

“…Adult cardiomyocytes (CM) retain little capacity to regenerate, which motivates efforts to engineer heart tissues that can emulate the functional and…”
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Industrializing Autologous Adoptive Immunotherapies: Manufacturing Advances and Challenges by Iyer, Rohin K, Bowles, Paul A, Kim, Howard, Dulgar-Tulloch, Aaron

“…Cell therapy has proven to be a burgeoning field of investigation, evidenced by hundreds of clinical trials being conducted worldwide across a variety of cell…”
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Successful expansion and cryopreservation of human natural killer cell line NK-92 for clinical manufacturing by Lee, Seul, Joo, Yunjoo, Lee, Eun Ji, Byeon, Youngseon, Kim, Jae-Hwan, Pyo, Kyoung-Ho, Kim, Young Seob, Lim, Sun Min, Kilbride, Peter, Iyer, Rohin K, Li, Mingming, French, Mandy C, Lee, Jung-Yub, Kang, Jeeheon, Byun, Hyesin, Cho, Byoung Chul

“…Natural killer (NK) cells have recently shown renewed promise as therapeutic cells for use in treating hematologic cancer indications. Despite this promise, NK…”
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Micro- and nanotechnology in cell separation by Radisic, Milica, Iyer, Rohin K, Murthy, Shashi K

“…This review describes recent work in cell separation using micro- and nanoscale technologies. These devices offer several advantages over conventional,…”
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Engineering surfaces for site-specific vascular differentiation of mouse embryonic stem cells by Chiang, C. Katherine, Chowdhury, Mohammad Fahad, Iyer, Rohin K., Stanford, William L., Radisic, Milica

“…Differentiation of stem and progenitor cells routinely relies on the application of soluble growth factors, an approach that enables temporal control of cell…”
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Mesenchymal stem cell treatment is associated with decreased perfusate concentration of interleukin-8 during ex vivo perfusion of donor lungs after 18-hour preservation by Mordant, Pierre, Nakajima, Daisuke, Kalaf, Ricardo, Iskender, Ilker, Maahs, Lucas, Behrens, Paula, Coutinho, Rafael, Iyer, Rohin K., Davies, John E., Cypel, Marcelo, Liu, Mingyao, Waddell, Thomas K., Keshavjee, Shaf

“…Ex vivo lung perfusion (EVLP) presents a unique therapeutic opportunity to administer mesenchymal stromal cells (MSCs) to lung grafts before transplantation…”
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Mesenchymal stromal cell therapy during ex vivo lung perfusion ameliorates ischemia-reperfusion injury in lung transplantation by Nakajima, Daisuke, Watanabe, Yui, Ohsumi, Akihiro, Pipkin, Mauricio, Chen, Manyin, Mordant, Pierre, Kanou, Takashi, Saito, Tomohito, Lam, Ryan, Coutinho, Rafael, Caldarone, Lindsay, Juvet, Stephen, Martinu, Tereza, Iyer, Rohin K., Davies, John E., Hwang, David M., Waddell, Thomas K., Cypel, Marcelo, Liu, Mingyao, Keshavjee, Shaf

“…The application of mesenchymal stromal cell (MSC)–based therapy during ex vivo lung perfusion (EVLP) could repair injured donor lungs before transplantation…”
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Engineered cardiac tissues by Iyer, Rohin K, Chiu, Loraine LY, Reis, Lewis A, Radisic, Milica

“…Highlights ► The review highlights recent advances in cardiac tissue engineering. ► We cover classical cell-scaffold approaches and advanced bioreactor…”
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Microfabricated poly(ethylene glycol) templates enable rapid screening of triculture conditions for cardiac tissue engineering by Iyer, Rohin K., Chiu, Loraine L. Y., Radisic, Milica

“…The purpose of this study was to design a simple system for cultivation of micro‐scale cardiac organoids and investigate the effects of cellular composition on…”
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Pulsatile perfusion bioreactor for cardiac tissue engineering by Brown, Melissa A., Iyer, Rohin K., Radisic, Milica

“…Cardiovascular disease is the number one cause of mortality in North America. Cardiac tissue engineering aims to engineer a contractile patch of physiological…”
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Biphasic electrical field stimulation aids in tissue engineering of multicell-type cardiac organoids by Chiu, Loraine L Y, Iyer, Rohin K, King, John-Paul, Radisic, Milica

“…The main objectives of current work were (1) to compare the effects of monophasic or biphasic electrical field stimulation on structure and function of…”
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Cardiac tissue engineering: current state and perspectives by Chiu, Loraine L Y, Iyer, Rohin K, Reis, Lewis A, Nunes, Sara S, Radisic, Milica

“…The goal of cardiac tissue engineering is to treat cardiovascular diseases through the implantation of engineered functional tissue replacements or the…”
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Vascular endothelial growth factor secretion by nonmyocytes modulates Connexin-43 levels in cardiac organoids by Iyer, Rohin K, Odedra, Devang, Chiu, Loraine L Y, Vunjak-Novakovic, Gordana, Radisic, Milica

“…We previously showed that the sequential, but not simultaneous, culture of endothelial cells (ECs), fibroblasts (FBs), and cardiomyocytes (CMs) resulted in…”
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Biomedical advances in the treatment of COVID-19: An Indo-Canadian perspective by Iyer, Rohin, Venkataramanan, Venkat, Pierce, Grant, Thakkar, Nikita, Natarajan, Valle, Chockalingam, Arun

“…This white paper summarizes the key outcomes, topics, and recommendations from the Canada-India Healthcare Summit 2021 Conference, Biotechnology Session, held…”
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Volatile organic compound (VOC) emissions of CHO and T cells correlate to their expansion in bioreactors by McCartney, Mitchell M, Yamaguchi, Mei S, Bowles, Paul A, Gratch, Yarden S, Iyer, Rohin K, Linderholm, Angela L, Ebeler, Susan E, Kenyon, Nicholas J, Schivo, Michael, Harper, Richart W, Goodwin, Paul, Davis, Cristina E

“…Volatile organic compound (VOC) emissions were measured from Chinese Hamster Ovary (CHO) cell and T cell bioreactor gas exhaust lines with the goal of…”
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Spatiotemporal tracking of cells in tissue-engineered cardiac organoids by Iyer, Rohin K., Chui, Jane, Radisic, Milica

“…Cardiac tissue engineering aims to create myocardial patches for repair of defective or damaged native heart muscle. The inclusion of non‐myocytes in…”
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Biofabrication enables efficient interrogation and optimization of sequential culture of endothelial cells, fibroblasts and cardiomyocytes for formation of vascular cords in cardiac tissue engineering by Iyer, Rohin K, Chiu, Loraine L Y, Vunjak-Novakovic, Gordana, Radisic, Milica

“…We previously reported that preculture of fibroblasts (FBs) and endothelial cells (ECs) prior to cardiomyocytes (CMs) improved the structural and functional…”
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Controlled capture and release of cardiac fibroblasts using peptide-functionalized alginate gels in microfluidic channels by Plouffe, Brian D, Brown, Melissa A, Iyer, Rohin K, Radisic, Milica, Murthy, Shashi K

“…The utilization of peptide-functionalized hydrogels in combination with a divalent chelator offers an effective methodology for capture and release of cells…”
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Optical mapping of impulse propagation in engineered cardiac tissue by Radisic, Milica, Fast, Vladimir G, Sharifov, Oleg F, Iyer, Rohin K, Park, Hyoungshin, Vunjak-Novakovic, Gordana

“…Cardiac tissue engineering has a potential to provide functional, synchronously contractile tissue constructs for heart repair, and for studies of development…”
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Synthetic oxygen carriers in cardiac tissue engineering by Iyer, Rohin K, Radisic, Milica, Cannizzaro, Chris, Vunjak-Novakovic, Gordana

“…The prominence of cardiovascular diseases has prompted investigations into alternative treatment options, including tissue engineering. Currently, the biggest…”
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