Search Results - "Iyengar, Sudha K."

Genetic evidence for role of carotenoids in age-related macular degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS) by Meyers, Kristin J, Mares, Julie A, Igo, Jr, Robert P, Truitt, Barbara, Liu, Zhe, Millen, Amy E, Klein, Michael, Johnson, Elizabeth J, Engelman, Corinne D, Karki, Chitra K, Blodi, Barbara, Gehrs, Karen, Tinker, Lesley, Wallace, Robert, Robinson, Jennifer, LeBlanc, Erin S, Sarto, Gloria, Bernstein, Paul S, SanGiovanni, John Paul, Iyengar, Sudha K

“…We tested variants in genes related to lutein and zeaxanthin status for association with age-related macular degeneration (AMD) in the Carotenoids in…”
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Inhibition of EGF Signaling Protects the Diabetic Retina from Insulin-Induced Vascular Leakage by Sugimoto, Masahiko, Cutler, Alecia, Shen, Bailey, Moss, Scot E, Iyengar, Sudha K, Klein, Ronald, Folkman, Judah, Anand-Apte, Bela

“…Diabetes mellitus is a disease with considerable morbidity and mortality worldwide. Breakdown of the blood–retinal barrier and leakage from the retinal…”
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Five-year progression of unilateral age-related macular degeneration to bilateral involvement: the Three Continent AMD Consortium report by Joachim, Nichole, Colijn, Johanna Maria, Kifley, Annette, Lee, Kristine E, Buitendijk, Gabriëlle H S, Klein, Barbara E K, Myers, Chelsea E, Meuer, Stacy M, Tan, Ava G, Holliday, Elizabeth G, Attia, John, Liew, Gerald, Iyengar, Sudha K, de Jong, Paulus T V M, Hofman, Albert, Vingerling, Johannes R, Mitchell, Paul, Klaver, Caroline C W, Klein, Ronald, Wang, Jie Jin

“…To assess the 5-year progression from unilateral to bilateral age-related macular degeneration (AMD) and associated risk factors. Pooled data analyses of three…”
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Joint Associations of Diet, Lifestyle, and Genes with Age-Related Macular Degeneration by Meyers, Kristin J., PhD, Liu, Zhe, MS, Millen, Amy E., PhD, Iyengar, Sudha K., PhD, Blodi, Barbara A., MD, Johnson, Elizabeth, PhD, Snodderly, D. Max, PhD, Klein, Michael L., MD, Gehrs, Karen M., MD, Tinker, Lesley, PhD, Sarto, Gloria E., MD, Robinson, Jennifer, MD, Wallace, Robert B., MD, Mares, Julie A., PhD

“…Purpose Unhealthy lifestyles have been associated with increased odds for age-related macular degeneration (AMD). Whether this association is modified by…”
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Characterizing the pathogenicity of genetic variants: the consequences of context by Ciesielski, Timothy H., Sirugo, Giorgio, Iyengar, Sudha K., Williams, Scott M.

“…Beyond initial discovery of a pathogenic variant, establishing that a variant is recurrently associated with disease is important for understanding clinical…”
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Genetic determinants of macular pigments in women of the Carotenoids in Age-Related Eye Disease Study by Meyers, Kristin J, Johnson, Elizabeth J, Bernstein, Paul S, Iyengar, Sudha K, Engelman, Corinne D, Karki, Chitra K, Liu, Zhe, Igo, Jr, Robert P, Truitt, Barbara, Klein, Michael L, Snodderly, D Max, Blodi, Barbara A, Gehrs, Karen M, Sarto, Gloria E, Wallace, Robert B, Robinson, Jennifer, LeBlanc, Erin S, Hageman, Gregory, Tinker, Lesley, Mares, Julie A

“…To investigate genetic determinants of macular pigment optical density in women from the Carotenoids in Age-Related Eye Disease Study (CAREDS), an ancillary…”
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Feature-driven classification reveals potential comorbid subtypes within childhood apraxia of speech by Stein, Catherine M, Benchek, Penelope, Miller, Gabrielle, Hall, Noémi B, Menon, Dhanya, Freebairn, Lisa, Tag, Jessica, Vick, Jennell, Taylor, H Gerry, Lewis, Barbara A, Iyengar, Sudha K

“…Childhood apraxia of speech (CAS) is a neurodevelopmental disorder with heterogeneous communication and other comorbid manifestations. While previous studies…”
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The Relationship of Cataract and Cataract Extraction to Age-related Macular Degeneration: The Beaver Dam Eye Study by Klein, Barbara E.K., MD, MPH, Howard, Kerri P., MS, Lee, Kristine E., MS, Iyengar, Sudha K., PhD, Sivakumaran, Theru A., PhD, Klein, Ronald, MD, MPH

“…Objective To examine the associations of cataract and cataract surgery with early and late age-related macular degeneration (AMD) over a 20-year interval…”
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Differing roles for TCF4 and COL8A2 in central corneal thickness and fuchs endothelial corneal dystrophy by Igo, Jr, Robert P, Kopplin, Laura J, Joseph, Peronne, Truitt, Barbara, Fondran, Jeremy, Bardenstein, David, Aldave, Anthony J, Croasdale, Christopher R, Price, Marianne O, Rosenwasser, Miriam, Lass, Jonathan H, Iyengar, Sudha K

“…Fuchs endothelial corneal dystrophy (FECD) is the most common late-onset, vision-threatening corneal dystrophy in the United States, affecting about 4% of the…”
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Importance of copy number variants in childhood apraxia of speech and other speech sound disorders by Chan, E. Ricky, Benchek, Penelope, Miller, Gabrielle, Brustoski, Kim, Schaffer, Ashleigh, Truitt, Barbara, Tag, Jessica, Freebairn, Lisa, Lewis, Barbara A., Stein, Catherine M., Iyengar, Sudha K.

“…Childhood apraxia of speech (CAS) is a severe and rare form of speech sound disorder (SSD). CAS is typically sporadic, but may segregate in families with…”
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Vitamin D intake and season modify the effects of the GC and CYP2R1 genes on 25-hydroxyvitamin D concentrations by Engelman, Corinne D, Meyers, Kristin J, Iyengar, Sudha K, Liu, Zhe, Karki, Chitra K, Igo, Jr, Robert P, Truitt, Barbara, Robinson, Jennifer, Sarto, Gloria E, Wallace, Robert, Blodi, Barbara A, Klein, Michael L, Tinker, Lesley, LeBlanc, Erin S, Jackson, Rebecca D, Song, Yiqing, Manson, JoAnn E, Mares, Julie A, Millen, Amy E

“…Vitamin D deficiency {defined by the blood concentration of 25-hydroxyvitamin D [25(OH)D]} has been associated with many adverse health outcomes. Genetic and…”
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EPHA2 is associated with age-related cortical cataract in mice and humans by Jun, Gyungah, Guo, Hong, Klein, Barbara E K, Klein, Ronald, Wang, Jie Jin, Mitchell, Paul, Miao, Hui, Lee, Kristine E, Joshi, Tripti, Buck, Matthias, Chugha, Preeti, Bardenstein, David, Klein, Alison P, Bailey-Wilson, Joan E, Gong, Xiaohua, Spector, Tim D, Andrew, Toby, Hammond, Christopher J, Elston, Robert C, Iyengar, Sudha K, Wang, Bingcheng

“…Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a…”
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The Relationship of Atherosclerosis to the 10-Year Cumulative Incidence of Age-related Macular Degeneration: The Beaver Dam Studies by Klein, Ronald, MD, MPH, Cruickshanks, Karen J., PhD, Myers, Chelsea E., MStat, Sivakumaran, Theru A., PhD, Iyengar, Sudha K., PhD, Meuer, Stacy M., BS, Schubert, Carla R., MS, Gangnon, Ronald E., PhD, Klein, Barbara E.K., MD, MPH

“…Objective To describe the relationships of intima–media thickness (IMT), plaque in the carotid artery, angina, myocardial infarction (MI), and stroke to the…”
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Harmonizing the Classification of Age-related Macular Degeneration in the Three-Continent AMD Consortium by Klein, Ronald, Meuer, Stacy M., Myers, Chelsea E., Buitendijk, Gabriëlle H. S., Rochtchina, Elena, Choudhury, Farzana, de Jong, Paulus T. V. M., McKean-Cowdin, Roberta, Iyengar, Sudha K., Gao, Xiaoyi, Lee, Kristine E., Vingerling, Johannes R., Mitchell, Paul, Klaver, Caroline C. W., Wang, Jie Jin, Klein, Barbara E. K.

“…Abstract Purpose: To describe methods to harmonize the classification of age-related macular degeneration (AMD) phenotypes across four population-based cohort…”
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Genome scan of M. tuberculosis infection and disease in Ugandans by Stein, Catherine M, Zalwango, Sarah, Malone, LaShaunda L, Won, Sungho, Mayanja-Kizza, Harriet, Mugerwa, Roy D, Leontiev, Dmitry V, Thompson, Cheryl L, Cartier, Kevin C, Elston, Robert C, Iyengar, Sudha K, Boom, W Henry, Whalen, Christopher C

“…Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is an enduring public health problem globally, particularly in sub-Saharan Africa. Several…”
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Mitochondrial DNA variants of respiratory complex I that uniquely characterize haplogroup T2 are associated with increased risk of age-related macular degeneration by SanGiovanni, John Paul, Arking, Dan E, Iyengar, Sudha K, Elashoff, Michael, Clemons, Traci E, Reed, George F, Henning, Alice K, Sivakumaran, Theru A, Xu, Xuming, DeWan, Andrew, Agrón, Elvira, Rochtchina, Elena, Sue, Carolyn M, Wang, Jie Jin, Mitchell, Paul, Hoh, Josephine, Francis, Peter J, Klein, Michael L, Chew, Emily Y, Chakravarti, Aravinda

“…Age-related macular degeneration (AMD), a chronic neurodegenerative and neovascular retinal disease, is the leading cause of blindness in elderly people of…”
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Patterns of risk for diabetic retinopathy in the Mumbai slums: The Aditya Jyot Diabetic Retinopathy in Urban Mumbai Slums Study (AJ-DRUMSS) Report 3 by Krishnan, Radhika, Jain, Astha, Nare, Siddhita, Sankaranarayanan, Rajkumar, Bartlett, Jacquelaine, Iyengar, Sudha K, Williams, Scott M, Sundaram, Natarajan

“…Diabetes onset precedes diabetic retinopathy (DR) by 5-10 years, but many people with diabetes remain free of this microvascular complication. Our aim was to…”
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CKD Increases the Risk of Age-Related Macular Degeneration by LIEW, Gerald, MITCHELL, Paul, TIEN YIN WONG, IYENGAR, Sudha K, JIE JIN WANG

“…Age-related macular degeneration is the leading cause of irreversible blindness in the United States and often coexists with chronic kidney disease. Both…”
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A multi-ancestry GWAS of Fuchs corneal dystrophy highlights the contributions of laminins, collagen, and endothelial cell regulation by Gorman, Bryan R., Francis, Michael, Nealon, Cari L., Halladay, Christopher W., Duro, Nalvi, Markianos, Kyriacos, Genovese, Giulio, Hysi, Pirro G., Choquet, Hélène, Afshari, Natalie A., Li, Yi-Ju, Gaziano, J. Michael, Hung, Adriana M., Wu, Wen-Chih, Greenberg, Paul B., Pyarajan, Saiju, Lass, Jonathan H., Peachey, Neal S., Iyengar, Sudha K.

“…Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal transplantation, but its molecular etiology remains poorly understood. We…”
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A translational genomics approach identifies IL10RB as the top candidate gene target for COVID-19 susceptibility by Voloudakis, Georgios, Vicari, James M., Venkatesh, Sanan, Hoffman, Gabriel E., Dobrindt, Kristina, Zhang, Wen, Beckmann, Noam D., Higgins, Christina A., Argyriou, Stathis, Jiang, Shan, Hoagland, Daisy, Gao, Lina, Corvelo, André, Cho, Kelly, Lee, Kyung Min, Bian, Jiantao, Lee, Jennifer S., Iyengar, Sudha K., Luoh, Shiuh-Wen, Akbarian, Schahram, Striker, Robert, Assimes, Themistocles L., Schadt, Eric E., Lynch, Julie A., Merad, Miriam, tenOever, Benjamin R., Charney, Alexander W., Brennand, Kristen J., Fullard, John F., Roussos, Panos

“…Recent efforts have identified genetic loci that are associated with coronavirus disease 2019 (COVID-19) infection rates and disease outcome severity…”
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